GB1234624A - - Google Patents
Info
- Publication number
- GB1234624A GB1234624A GB1234624DA GB1234624A GB 1234624 A GB1234624 A GB 1234624A GB 1234624D A GB1234624D A GB 1234624DA GB 1234624 A GB1234624 A GB 1234624A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- piperazin
- alkoxy
- och
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,234,624. Oxazinoisoquinoline derivatives. J. R. GEIGY A.G. 30 April, 1968 [1 May, 1967], No. 20327/68. Heading C2C. Compounds of the general formula (R 1 =H, C 1-3 alkoxy; R 2 , 3 =C 1-3 alkoxy or (when R 1 =H) R 2+3 =OCH 2 O; Am=NH 2 , C 1-3 alkylamino, di-(C 1-3 alkyl)amino, morpholino, 1-pyrrolidinyl, piperidino, 1-piperazinyl, 4- (C 1-3 alkyl)piperazin-l-yl, 4-(3 2-3 -hydroxyalkyl)- piperazin - 1 - yl, 4- (C 1-3 alkoxy - C 2-3 alkyl)- piperazin-l-yl)) and their acid addition salts are prepared by (a) reacting a compound of the formula (X=Cl, Br, C 1-3 alkoxy, OCH 2 CN, OC 6 H 4 NO 2 - (p), C 2-5 alkoxycarbonyl, O.CO.OCH 2 Ph) with HAm or an alkali metal derivative thereof, (b) cyclizing a compound of the formula (Am<SP>1</SP>=di-(C 1-3 alkyl)amino, morpholino, 1- pyrrolidinyl, piperidino, 4-(C 1-3 alkyl)piperazin- 1-yl) and reducing the product or (c)-when Am=NH 2 -hydrolysing the corresponding hitrile, optionally followed in each case by salt formation and/or isomer separation or resolution. The above compounds are tranquilizers and muscle relaxants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63485667A | 1967-05-01 | 1967-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1234624A true GB1234624A (en) | 1971-06-09 |
Family
ID=24545439
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1234625D Expired GB1234625A (en) | 1967-05-01 | 1968-04-30 | |
| GB1234624D Expired GB1234624A (en) | 1967-05-01 | 1968-04-30 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1234625D Expired GB1234625A (en) | 1967-05-01 | 1968-04-30 |
Country Status (12)
| Country | Link |
|---|---|
| AT (3) | AT277273B (en) |
| BE (1) | BE714508A (en) |
| CH (1) | CH499538A (en) |
| DE (1) | DE1770304A1 (en) |
| DK (1) | DK125422B (en) |
| ES (3) | ES353394A1 (en) |
| FR (3) | FR1578899A (en) |
| GB (2) | GB1234625A (en) |
| IE (1) | IE32045B1 (en) |
| IL (1) | IL29920A (en) |
| NL (1) | NL6805805A (en) |
| SE (1) | SE343586B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191301B (en) * | 1984-03-23 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives |
-
1968
- 1968-04-24 DK DK185068AA patent/DK125422B/en unknown
- 1968-04-24 SE SE5540/68A patent/SE343586B/xx unknown
- 1968-04-24 NL NL6805805A patent/NL6805805A/xx unknown
- 1968-04-30 BE BE714508D patent/BE714508A/xx unknown
- 1968-04-30 AT AT00989/69A patent/AT277273B/en active
- 1968-04-30 AT AT419468A patent/AT277271B/en not_active IP Right Cessation
- 1968-04-30 GB GB1234625D patent/GB1234625A/en not_active Expired
- 1968-04-30 DE DE19681770304 patent/DE1770304A1/en active Pending
- 1968-04-30 IE IE506/68A patent/IE32045B1/en unknown
- 1968-04-30 ES ES353394A patent/ES353394A1/en not_active Expired
- 1968-04-30 IL IL29920A patent/IL29920A/en unknown
- 1968-04-30 CH CH638268A patent/CH499538A/en not_active IP Right Cessation
- 1968-04-30 AT AT00988/69A patent/AT277272B/en not_active IP Right Cessation
- 1968-04-30 GB GB1234624D patent/GB1234624A/en not_active Expired
- 1968-04-30 ES ES353393A patent/ES353393A1/en not_active Expired
- 1968-04-30 ES ES353395A patent/ES353395A1/en not_active Expired
- 1968-05-02 FR FR1578899D patent/FR1578899A/fr not_active Expired
- 1968-07-30 FR FR161146A patent/FR7706M/fr not_active Expired
- 1968-07-30 FR FR161145A patent/FR7645M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE32045L (en) | 1968-11-01 |
| IL29920A0 (en) | 1968-06-20 |
| FR1578899A (en) | 1969-08-22 |
| FR7706M (en) | 1970-02-23 |
| IE32045B1 (en) | 1973-03-21 |
| AT277272B (en) | 1969-12-29 |
| ES353394A1 (en) | 1969-10-01 |
| ES353395A1 (en) | 1969-10-01 |
| ES353393A1 (en) | 1969-09-01 |
| IL29920A (en) | 1972-04-27 |
| FR7645M (en) | 1970-02-02 |
| SE343586B (en) | 1972-03-13 |
| DE1770304A1 (en) | 1971-10-21 |
| DK125422B (en) | 1973-02-19 |
| NL6805805A (en) | 1968-11-04 |
| GB1234625A (en) | 1971-06-09 |
| BE714508A (en) | 1968-10-30 |
| CH499538A (en) | 1970-11-30 |
| AT277271B (en) | 1969-12-29 |
| AT277273B (en) | 1969-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |