IE32045B1 - Novel oxazinoisoquinoline derivatives;processes for their production and compositions containing same - Google Patents

Novel oxazinoisoquinoline derivatives;processes for their production and compositions containing same

Info

Publication number
IE32045B1
IE32045B1 IE506/68A IE50668A IE32045B1 IE 32045 B1 IE32045 B1 IE 32045B1 IE 506/68 A IE506/68 A IE 506/68A IE 50668 A IE50668 A IE 50668A IE 32045 B1 IE32045 B1 IE 32045B1
Authority
IE
Ireland
Prior art keywords
alkyl
piperazin
alkoxy
oxazinoisoquinoline
derivatives
Prior art date
Application number
IE506/68A
Other versions
IE32045L (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to IE1071/71A priority Critical patent/IE32046B1/en
Publication of IE32045L publication Critical patent/IE32045L/en
Publication of IE32045B1 publication Critical patent/IE32045B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,234,624. Oxazinoisoquinoline derivatives. J. R. GEIGY A.G. 30 April, 1968 [1 May, 1967], No. 20327/68. Heading C2C. Compounds of the general formula (R 1 =H, C 1-3 alkoxy; R 2 , 3 =C 1-3 alkoxy or (when R 1 =H) R 2+3 =OCH 2 O; Am=NH 2 , C 1-3 alkylamino, di-(C 1-3 alkyl)amino, morpholino, 1-pyrrolidinyl, piperidino, 1-piperazinyl, 4- (C 1-3 alkyl)piperazin-l-yl, 4-(3 2-3 -hydroxyalkyl)- piperazin - 1 - yl, 4- (C 1-3 alkoxy - C 2-3 alkyl)- piperazin-l-yl)) and their acid addition salts are prepared by (a) reacting a compound of the formula (X=Cl, Br, C 1-3 alkoxy, OCH 2 CN, OC 6 H 4 NO 2 - (p), C 2-5 alkoxycarbonyl, O.CO.OCH 2 Ph) with HAm or an alkali metal derivative thereof, (b) cyclizing a compound of the formula (Am<SP>1</SP>=di-(C 1-3 alkyl)amino, morpholino, 1- pyrrolidinyl, piperidino, 4-(C 1-3 alkyl)piperazin- 1-yl) and reducing the product or (c)-when Am=NH 2 -hydrolysing the corresponding hitrile, optionally followed in each case by salt formation and/or isomer separation or resolution. The above compounds are tranquilizers and muscle relaxants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. [GB1234624A]
IE506/68A 1967-05-01 1968-04-30 Novel oxazinoisoquinoline derivatives;processes for their production and compositions containing same IE32045B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE1071/71A IE32046B1 (en) 1967-05-01 1968-04-30 Improvements in or relating to novel derivatives of (1,4)oxazino(3,4a)isoquinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63485667A 1967-05-01 1967-05-01

Publications (2)

Publication Number Publication Date
IE32045L IE32045L (en) 1968-11-01
IE32045B1 true IE32045B1 (en) 1973-03-21

Family

ID=24545439

Family Applications (1)

Application Number Title Priority Date Filing Date
IE506/68A IE32045B1 (en) 1967-05-01 1968-04-30 Novel oxazinoisoquinoline derivatives;processes for their production and compositions containing same

Country Status (12)

Country Link
AT (3) AT277273B (en)
BE (1) BE714508A (en)
CH (1) CH499538A (en)
DE (1) DE1770304A1 (en)
DK (1) DK125422B (en)
ES (3) ES353393A1 (en)
FR (3) FR1578899A (en)
GB (2) GB1234624A (en)
IE (1) IE32045B1 (en)
IL (1) IL29920A (en)
NL (1) NL6805805A (en)
SE (1) SE343586B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU191301B (en) * 1984-03-23 1987-02-27 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives

Also Published As

Publication number Publication date
IL29920A0 (en) 1968-06-20
IL29920A (en) 1972-04-27
GB1234625A (en) 1971-06-09
ES353395A1 (en) 1969-10-01
AT277271B (en) 1969-12-29
GB1234624A (en) 1971-06-09
BE714508A (en) 1968-10-30
DE1770304A1 (en) 1971-10-21
IE32045L (en) 1968-11-01
FR1578899A (en) 1969-08-22
CH499538A (en) 1970-11-30
FR7706M (en) 1970-02-23
FR7645M (en) 1970-02-02
ES353394A1 (en) 1969-10-01
ES353393A1 (en) 1969-09-01
AT277272B (en) 1969-12-29
DK125422B (en) 1973-02-19
SE343586B (en) 1972-03-13
NL6805805A (en) 1968-11-04
AT277273B (en) 1969-12-29

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