GB1234118A - - Google Patents
Info
- Publication number
- GB1234118A GB1234118A GB1234118DA GB1234118A GB 1234118 A GB1234118 A GB 1234118A GB 1234118D A GB1234118D A GB 1234118DA GB 1234118 A GB1234118 A GB 1234118A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- methoxy
- hydroxy
- prepared
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 2
- 150000003936 benzamides Chemical class 0.000 abstract 2
- IIFCLXHRIYTHPV-UHFFFAOYSA-N methyl 2,4-dihydroxybenzoate Chemical compound COC(=O)C1=CC=C(O)C=C1O IIFCLXHRIYTHPV-UHFFFAOYSA-N 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- LKKDOFSIQKPJLX-UHFFFAOYSA-N (4-chloro-3-methylphenyl) acetate Chemical compound CC(=O)OC1=CC=C(Cl)C(C)=C1 LKKDOFSIQKPJLX-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- MMRJLQJSFOSVAM-UHFFFAOYSA-N 4-chloro-2,5-dimethylphenol Chemical compound CC1=CC(Cl)=C(C)C=C1O MMRJLQJSFOSVAM-UHFFFAOYSA-N 0.000 abstract 1
- XPKNIGFRIFWPQP-UHFFFAOYSA-N 5-chloro-2-methoxy-4-methylbenzoic acid Chemical compound COC1=CC(C)=C(Cl)C=C1C(O)=O XPKNIGFRIFWPQP-UHFFFAOYSA-N 0.000 abstract 1
- HZQVOUPMYMWPEQ-UHFFFAOYSA-N 5-chloro-2-methoxy-4-methylbenzoyl chloride Chemical compound COC1=CC(C)=C(Cl)C=C1C(Cl)=O HZQVOUPMYMWPEQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical class ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 abstract 1
- 229940073608 benzyl chloride Drugs 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 heterocyclic amines Chemical class 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- PHYPTZODBQEMJU-UHFFFAOYSA-N methyl 2-hydroxy-4-phenylmethoxybenzoate Chemical compound C1=C(O)C(C(=O)OC)=CC=C1OCC1=CC=CC=C1 PHYPTZODBQEMJU-UHFFFAOYSA-N 0.000 abstract 1
- OETWYXYUXBMROV-UHFFFAOYSA-N methyl 2-methoxy-4-phenylmethoxybenzoate Chemical compound C1=C(OC)C(C(=O)OC)=CC=C1OCC1=CC=CC=C1 OETWYXYUXBMROV-UHFFFAOYSA-N 0.000 abstract 1
- KCWJRQPHPPKPBK-UHFFFAOYSA-N methyl 4-hydroxy-2-methoxybenzoate Chemical compound COC(=O)C1=CC=C(O)C=C1OC KCWJRQPHPPKPBK-UHFFFAOYSA-N 0.000 abstract 1
- CGVQMFDUPUQCBB-UHFFFAOYSA-N methyl 5-chloro-4-hydroxy-2-methoxybenzoate Chemical compound COC(=O)C1=CC(Cl)=C(O)C=C1OC CGVQMFDUPUQCBB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001035 methylating effect Effects 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000003033 spasmogenic effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR161593A FR7707M (enrdf_load_stackoverflow) | 1968-08-01 | 1968-08-01 | |
| FR171761 | 1968-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1234118A true GB1234118A (enrdf_load_stackoverflow) | 1971-06-03 |
Family
ID=26182167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1234118D Expired GB1234118A (enrdf_load_stackoverflow) | 1968-08-01 | 1969-07-28 |
Country Status (22)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789683A (en) * | 1981-03-11 | 1988-12-06 | Astra Lakemedel Aktiebolag | Benzamido-derivatives |
| US4937260A (en) * | 1982-09-09 | 1990-06-26 | Astra Lakemedal Aktiebolag | Benzamido-derivatives |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5212117U (enrdf_load_stackoverflow) * | 1975-07-15 | 1977-01-27 | ||
| IL52645A (en) * | 1976-08-05 | 1980-02-29 | Synthelabo | Optically active 1 substituted 2 aminomethyl pyrrolidines stereospecifics synthesis thereof and process for the preparation of optically active 2 methoxy n pyrrolidylmethyl benzamides |
-
1969
- 1969-07-21 CH CH1115769A patent/CH507938A/fr not_active IP Right Cessation
- 1969-07-23 OA OA53680A patent/OA03889A/xx unknown
- 1969-07-23 DE DE1937515A patent/DE1937515C3/de not_active Expired
- 1969-07-23 DE DE19691966215 patent/DE1966215A1/de not_active Withdrawn
- 1969-07-24 SE SE10434/69A patent/SE359830B/xx unknown
- 1969-07-24 IE IE1027/69A patent/IE33541B1/xx unknown
- 1969-07-25 MC MC834A patent/MC806A1/xx unknown
- 1969-07-25 BE BE736560D patent/BE736560A/xx not_active IP Right Cessation
- 1969-07-26 ES ES369930A patent/ES369930A1/es not_active Expired
- 1969-07-26 BG BG012749A patent/BG17299A3/xx unknown
- 1969-07-27 IL IL32712A patent/IL32712A/xx unknown
- 1969-07-28 LU LU59176D patent/LU59176A1/xx unknown
- 1969-07-28 GB GB1234118D patent/GB1234118A/en not_active Expired
- 1969-07-29 FI FI692247A patent/FI52214C/fi active
- 1969-07-29 YU YU1965/69A patent/YU34289B/xx unknown
- 1969-07-30 CA CA058,341*7A patent/CA955949A/en not_active Expired
- 1969-07-31 DK DK414169AA patent/DK142844B/da not_active IP Right Cessation
- 1969-07-31 JP JP44060979A patent/JPS4837267B1/ja active Pending
- 1969-07-31 NL NL696911713A patent/NL142410B/xx not_active IP Right Cessation
- 1969-07-31 BR BR211217/69A patent/BR6911217D0/pt unknown
- 1969-07-31 NO NO3148/69A patent/NO131834C/no unknown
- 1969-08-01 RO RO60706A patent/RO55778A/ro unknown
-
1973
- 1973-05-02 PH PH14575A patent/PH11002A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789683A (en) * | 1981-03-11 | 1988-12-06 | Astra Lakemedel Aktiebolag | Benzamido-derivatives |
| US4937260A (en) * | 1982-09-09 | 1990-06-26 | Astra Lakemedal Aktiebolag | Benzamido-derivatives |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |