GB1223881A - Method of synthesis of 5-benzyl pyrimidine derivatives - Google Patents
Method of synthesis of 5-benzyl pyrimidine derivativesInfo
- Publication number
- GB1223881A GB1223881A GB524668A GB524668A GB1223881A GB 1223881 A GB1223881 A GB 1223881A GB 524668 A GB524668 A GB 524668A GB 524668 A GB524668 A GB 524668A GB 1223881 A GB1223881 A GB 1223881A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- synthesis
- benzyl
- pyrimidine derivatives
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NPYPQKXJJZZSAX-UHFFFAOYSA-N 5-benzylpyrimidine Chemical class C=1N=CN=CC=1CC1=CC=CC=C1 NPYPQKXJJZZSAX-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- -1 2,4 - Diamino - 5 - (substituted benzyl)-pyrimidines Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61345067A | 1967-02-02 | 1967-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1223881A true GB1223881A (en) | 1971-03-03 |
Family
ID=24457367
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4951470A Expired GB1223882A (en) | 1967-02-02 | 1968-02-01 | 5-benzylpyrimidine derivatives |
| GB524668A Expired GB1223881A (en) | 1967-02-02 | 1968-02-01 | Method of synthesis of 5-benzyl pyrimidine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4951470A Expired GB1223882A (en) | 1967-02-02 | 1968-02-01 | 5-benzylpyrimidine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE710100A (enrdf_load_stackoverflow) |
| ES (1) | ES350062A1 (enrdf_load_stackoverflow) |
| GB (2) | GB1223882A (enrdf_load_stackoverflow) |
| IE (1) | IE32312B1 (enrdf_load_stackoverflow) |
| NL (1) | NL6801540A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2249532A1 (de) * | 1971-10-12 | 1973-04-26 | Wellcome Found | Verfahren zur herstellung von 2,4-diamino-5-benzylpyrimidinen |
| US4180578A (en) | 1977-05-09 | 1979-12-25 | Ludwig Heumann, & Co. GmbH | 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use |
| JPS5536662B1 (enrdf_load_stackoverflow) * | 1970-10-22 | 1980-09-22 | ||
| EP0054756B1 (en) * | 1980-11-27 | 1986-07-23 | The Wellcome Foundation Limited | Antibacterial benzylpyrimidines |
-
1968
- 1968-01-30 BE BE710100D patent/BE710100A/xx not_active IP Right Cessation
- 1968-02-01 GB GB4951470A patent/GB1223882A/en not_active Expired
- 1968-02-01 GB GB524668A patent/GB1223881A/en not_active Expired
- 1968-02-01 ES ES350062A patent/ES350062A1/es not_active Expired
- 1968-02-02 NL NL6801540A patent/NL6801540A/xx unknown
- 1968-02-02 IE IE13668A patent/IE32312B1/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5536662B1 (enrdf_load_stackoverflow) * | 1970-10-22 | 1980-09-22 | ||
| DE2249532A1 (de) * | 1971-10-12 | 1973-04-26 | Wellcome Found | Verfahren zur herstellung von 2,4-diamino-5-benzylpyrimidinen |
| US4180578A (en) | 1977-05-09 | 1979-12-25 | Ludwig Heumann, & Co. GmbH | 2,4-Diamino-5-(4'-methylthio)benzylpyrimidenes, compounds, compositions and method of use |
| EP0054756B1 (en) * | 1980-11-27 | 1986-07-23 | The Wellcome Foundation Limited | Antibacterial benzylpyrimidines |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6801540A (enrdf_load_stackoverflow) | 1968-08-05 |
| IE32312L (en) | 1968-08-02 |
| ES350062A1 (es) | 1969-11-16 |
| IE32312B1 (en) | 1973-06-27 |
| GB1223882A (en) | 1971-03-03 |
| BE710100A (enrdf_load_stackoverflow) | 1968-07-30 |
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