GB1223491A - Guanidines - Google Patents

Guanidines

Info

Publication number
GB1223491A
GB1223491A GB8629/68A GB862968A GB1223491A GB 1223491 A GB1223491 A GB 1223491A GB 8629/68 A GB8629/68 A GB 8629/68A GB 862968 A GB862968 A GB 862968A GB 1223491 A GB1223491 A GB 1223491A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
prepared
ethoxy
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8629/68A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Priority to GB8629/68A priority Critical patent/GB1223491A/en
Priority to GB39073/70A priority patent/GB1223492A/en
Priority to IL30782A priority patent/IL30782A/en
Priority to IN117863A priority patent/IN117863B/en
Priority to IT22075/68A priority patent/IT1062053B/it
Priority to PH9625A priority patent/PH10262A/en
Priority to BE722136D priority patent/BE722136A/xx
Priority to DE1802394A priority patent/DE1802394C2/de
Priority to DK492468AA priority patent/DK128350B/da
Priority to FR169646A priority patent/FR8343M/fr
Priority to SE6813751A priority patent/SE381041B/xx
Priority to FI682889A priority patent/FI49958C/fi
Priority to NL6814608.A priority patent/NL166014C/xx
Priority to CA032,413A priority patent/CA958018A/en
Priority to IE1223/68A priority patent/IE32417B1/xx
Priority to CH119372A priority patent/CH524577A/de
Priority to CH1534368A priority patent/CH560188A5/xx
Priority to IE1364/71A priority patent/IE32853B1/xx
Priority to BR20654969A priority patent/BR6906549D0/pt
Publication of GB1223491A publication Critical patent/GB1223491A/en
Priority to CA115885A priority patent/CA921829A/en
Priority to IN1068/CAL/1975A priority patent/IN141035B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8629/68A 1967-10-13 1968-02-22 Guanidines Expired GB1223491A (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GB8629/68A GB1223491A (en) 1967-10-13 1968-02-22 Guanidines
GB39073/70A GB1223492A (en) 1967-10-13 1968-02-22 Guanidines
IL30782A IL30782A (en) 1967-10-13 1968-09-29 Amino guanidines
IN117863A IN117863B (it) 1968-02-22 1968-10-03
IT22075/68A IT1062053B (it) 1967-10-13 1968-10-04 Amminoguanidine farmaceuticamente attive procedimento per la loro preparazione e composizioni farmaceutiche che le commengomo
PH9625A PH10262A (en) 1967-10-13 1968-10-07 Guanidines
BE722136D BE722136A (it) 1967-10-13 1968-10-10
DE1802394A DE1802394C2 (de) 1967-10-13 1968-10-10 Arzneimittel mit antihypertensiver Wirkung, die [(2,6-Dichlorbenzyliden)-amino]-guanidin oder ein Säureadditionssalz davon enthalten
FI682889A FI49958C (fi) 1967-10-13 1968-10-11 Menetelmä terapeuttisesti aktiivisen aminoguanidiini-johdannaisen valm istamiseksi.
FR169646A FR8343M (it) 1967-10-13 1968-10-11
SE6813751A SE381041B (sv) 1967-10-13 1968-10-11 Forfarande for framstellning av aminoguanidiner
DK492468AA DK128350B (da) 1967-10-13 1968-10-11 Analogifremgangsmåde til fremstilling af aminoguanidinderivater eller syreadditionssalte deraf til anvendelse i human- og veterinærmedicinen.
NL6814608.A NL166014C (nl) 1967-10-13 1968-10-11 Werkwijze voor het bereiden van farmaceutische preparaten en de onder toepassing daarvan verkregen gevormde voortbrengselen, alsmede werkwijze ter bereiding van farmacologisch werkzame benzylideen- aminoguanidinederivaten.
CA032,413A CA958018A (en) 1967-10-13 1968-10-12 Guanidines
CH119372A CH524577A (de) 1967-10-13 1968-10-14 Verfahren zur Herstellung von Aminoguanidinen
IE1223/68A IE32417B1 (en) 1967-10-13 1968-10-14 Guanidines
CH1534368A CH560188A5 (it) 1967-10-13 1968-10-14
IE1364/71A IE32853B1 (en) 1968-02-22 1968-10-14 Guanidines
BR20654969A BR6906549D0 (pt) 1968-02-22 1969-02-21 Processo para a preparacao de guanidinas
CA115885A CA921829A (en) 1967-10-13 1971-06-17 Guanidines
IN1068/CAL/1975A IN141035B (it) 1968-02-22 1975-05-27

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67502667A 1967-10-13 1967-10-13
GB8629/68A GB1223491A (en) 1967-10-13 1968-02-22 Guanidines
US75449468A 1968-08-21 1968-08-21

Publications (1)

Publication Number Publication Date
GB1223491A true GB1223491A (en) 1971-02-24

Family

ID=27255238

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8629/68A Expired GB1223491A (en) 1967-10-13 1968-02-22 Guanidines
GB39073/70A Expired GB1223492A (en) 1967-10-13 1968-02-22 Guanidines

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB39073/70A Expired GB1223492A (en) 1967-10-13 1968-02-22 Guanidines

Country Status (13)

Country Link
BE (1) BE722136A (it)
CA (2) CA958018A (it)
CH (2) CH524577A (it)
DE (1) DE1802394C2 (it)
DK (1) DK128350B (it)
FI (1) FI49958C (it)
GB (2) GB1223491A (it)
IE (1) IE32417B1 (it)
IL (1) IL30782A (it)
IT (1) IT1062053B (it)
NL (1) NL166014C (it)
PH (1) PH10262A (it)
SE (1) SE381041B (it)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021120A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0021121A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
US4602041A (en) * 1982-02-10 1986-07-22 Beecham Group P.L.C. Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses
EP0488897A1 (fr) * 1990-11-29 1992-06-03 Adir Et Compagnie Nouveaux dérivés de guanidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB2277090A (en) * 1993-04-16 1994-10-19 Shell Int Research Fungicidal tetrahydropyrimidine and imidazoline derivatives
WO1998023267A1 (en) * 1996-11-26 1998-06-04 Wapharm Ab Use of hydroxyguanidines
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
WO2002081430A2 (en) * 2001-04-05 2002-10-17 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
WO2008071980A1 (en) 2006-12-14 2008-06-19 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands.
US8148429B2 (en) 2000-08-07 2012-04-03 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
WO2016162689A1 (en) * 2015-04-08 2016-10-13 Medical Research Council Inhibitors and their uses
EP3109237A1 (en) * 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
US10100020B2 (en) 2013-01-10 2018-10-16 United Kingdom Research And Innovation Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases
EP3592147A4 (en) * 2017-03-06 2020-12-16 The United States of America as represented by the Secretary of Agriculture SELF-ASSEMBLED ACTIVE AGENTS

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH523232A (de) * 1968-12-16 1972-05-31 Sandoz Ag Verfahren zur Herstellung eines Benzylidenaminoguanidins
DE10149919A1 (de) 2001-10-10 2003-04-24 Biosphings Ag Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus
FR2893844B1 (fr) * 2005-11-28 2008-02-01 Centre Nat Rech Scient Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE958832C (de) * 1952-11-14 1957-02-28 Bayer Ag Verfahren zur Herstellung von Guanylhydrazonen
GB1019120A (en) * 1964-03-18 1966-02-02 Shell Int Research Novel hydrazine compounds and compositions containing them

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021120A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0021121A1 (en) * 1979-06-01 1981-01-07 The Wellcome Foundation Limited 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
EP0059987A1 (en) * 1979-06-01 1982-09-15 The Wellcome Foundation Limited Alpha-cyano-alpha-((N-guanidino)-imino) toluenes
US4486354A (en) * 1979-06-01 1984-12-04 Baxter Martin G Substituted aromatic compounds
US4560687A (en) * 1979-06-01 1985-12-24 Baxter Martin G Substituted aromatic compounds
US4602017A (en) * 1979-06-01 1986-07-22 Sawyer David A Substituted aromatic compounds
US4602041A (en) * 1982-02-10 1986-07-22 Beecham Group P.L.C. Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses
FR2669927A1 (fr) * 1990-11-29 1992-06-05 Adir Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0488897A1 (fr) * 1990-11-29 1992-06-03 Adir Et Compagnie Nouveaux dérivés de guanidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB2277090A (en) * 1993-04-16 1994-10-19 Shell Int Research Fungicidal tetrahydropyrimidine and imidazoline derivatives
WO1998023267A1 (en) * 1996-11-26 1998-06-04 Wapharm Ab Use of hydroxyguanidines
US6599943B1 (en) 1996-11-26 2003-07-29 Wapharm Ab Use of hydroxyguanidines
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
US8410174B2 (en) 2000-08-07 2013-04-02 Anamar Ab Method for treating arthritis
US9227927B2 (en) 2000-08-07 2016-01-05 Anamar Ab Method of treating inflammation
US8148429B2 (en) 2000-08-07 2012-04-03 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
US8309609B2 (en) 2000-08-07 2012-11-13 Anamar Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
WO2002081430A2 (en) * 2001-04-05 2002-10-17 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
WO2002081430A3 (en) * 2001-04-05 2003-08-14 Melacure Therapeutics Ab Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors
US8372878B2 (en) 2006-12-14 2013-02-12 Anamar Ab Aminoguanidines as melanocortin receptor ligands
WO2008071980A1 (en) 2006-12-14 2008-06-19 Acure Pharma Ab Novel aminoguanidines as melanocortin receptor ligands.
US10954198B2 (en) 2013-01-10 2021-03-23 United Kingdom Research And Innovation Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases
US10526297B2 (en) 2013-01-10 2020-01-07 Inflectis Bioscience Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases
US10100020B2 (en) 2013-01-10 2018-10-16 United Kingdom Research And Innovation Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases
CN107709291A (zh) * 2015-04-08 2018-02-16 医疗研究局 抑制剂及其应用
WO2016162689A1 (en) * 2015-04-08 2016-10-13 Medical Research Council Inhibitors and their uses
US11364211B2 (en) 2015-04-08 2022-06-21 United Kingdom Research And Innovation Methods for selecting phosphatase selective and non-selective phosphatase inhibitors
US11337941B2 (en) 2015-04-08 2022-05-24 United Kingdom Research And Innovation Inhibitors and their uses
US11331286B2 (en) 2015-04-08 2022-05-17 United Kingdom Research And Innovation Inhibitors and their uses
US11154519B2 (en) 2015-04-08 2021-10-26 United Kingdom Research And Innovation Inhibitors and their uses
RU2706229C2 (ru) * 2015-06-22 2019-11-15 Анамар Аб Новые антагонисты 5-нт2
US10544103B2 (en) 2015-06-22 2020-01-28 Anamar Ab 5-HT2 antagonists
CN107787321B (zh) * 2015-06-22 2021-10-01 安娜玛有限公司 新型5-ht2拮抗剂
EP3109237A1 (en) * 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN107787321A (zh) * 2015-06-22 2018-03-09 安娜玛有限公司 新型5‑ht2拮抗剂
WO2016207231A1 (en) * 2015-06-22 2016-12-29 Anamar Ab Novel 5-ht2 antagonists
JP2018522829A (ja) * 2015-06-22 2018-08-16 アナマー アーベー 新規の５−ｈｔ２アンタゴニスト
EP3592147A4 (en) * 2017-03-06 2020-12-16 The United States of America as represented by the Secretary of Agriculture SELF-ASSEMBLED ACTIVE AGENTS

Also Published As

Publication number Publication date
NL6814608A (it) 1969-04-15
IE32417B1 (en) 1973-07-25
DE1802394C2 (de) 1984-06-28
NL166014C (nl) 1981-06-15
NL166014B (nl) 1981-01-15
GB1223492A (en) 1971-02-24
FI49958B (it) 1975-07-31
BE722136A (it) 1969-04-10
IE32417L (en) 1969-04-13
CA958018A (en) 1974-11-19
IT1062053B (it) 1983-06-25
IL30782A (en) 1972-08-30
PH10262A (en) 1976-10-20
DK128350B (da) 1974-04-16
CH524577A (de) 1972-06-30
CA921829A (en) 1973-02-27
CH560188A5 (it) 1975-03-27
FI49958C (fi) 1975-11-10
DE1802394A1 (de) 1969-05-08
SE381041B (sv) 1975-11-24

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