GB1223491A - Guanidines - Google Patents
GuanidinesInfo
- Publication number
- GB1223491A GB1223491A GB8629/68A GB862968A GB1223491A GB 1223491 A GB1223491 A GB 1223491A GB 8629/68 A GB8629/68 A GB 8629/68A GB 862968 A GB862968 A GB 862968A GB 1223491 A GB1223491 A GB 1223491A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- prepared
- ethoxy
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002357 guanidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical class NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 abstract 1
- PAWIXECATDEZRE-UHFFFAOYSA-N 2,4,6-trichloro-3-ethoxybenzaldehyde Chemical class C(C)OC=1C(=C(C=O)C(=CC1Cl)Cl)Cl PAWIXECATDEZRE-UHFFFAOYSA-N 0.000 abstract 1
- WDZVGELJXXEGPV-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methylideneamino]guanidine Chemical compound NC(N)=NN=CC1=C(Cl)C=CC=C1Cl WDZVGELJXXEGPV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001539 anorectic effect Effects 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000000648 anti-parkinson Effects 0.000 abstract 1
- 230000000891 anti-reserpine Effects 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 206010061428 decreased appetite Diseases 0.000 abstract 1
- 230000000994 depressogenic effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003345 hyperglycaemic effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical group C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 230000002911 mydriatic effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000003236 psychic effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8629/68A GB1223491A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
| GB39073/70A GB1223492A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
| IL30782A IL30782A (en) | 1967-10-13 | 1968-09-29 | Amino guanidines |
| IN117863A IN117863B (enrdf_load_stackoverflow) | 1968-02-22 | 1968-10-03 | |
| IT22075/68A IT1062053B (it) | 1967-10-13 | 1968-10-04 | Amminoguanidine farmaceuticamente attive procedimento per la loro preparazione e composizioni farmaceutiche che le commengomo |
| PH9625A PH10262A (en) | 1967-10-13 | 1968-10-07 | Guanidines |
| BE722136D BE722136A (enrdf_load_stackoverflow) | 1967-10-13 | 1968-10-10 | |
| DE1802394A DE1802394C2 (de) | 1967-10-13 | 1968-10-10 | Arzneimittel mit antihypertensiver Wirkung, die [(2,6-Dichlorbenzyliden)-amino]-guanidin oder ein Säureadditionssalz davon enthalten |
| DK492468AA DK128350B (da) | 1967-10-13 | 1968-10-11 | Analogifremgangsmåde til fremstilling af aminoguanidinderivater eller syreadditionssalte deraf til anvendelse i human- og veterinærmedicinen. |
| NL6814608.A NL166014C (nl) | 1967-10-13 | 1968-10-11 | Werkwijze voor het bereiden van farmaceutische preparaten en de onder toepassing daarvan verkregen gevormde voortbrengselen, alsmede werkwijze ter bereiding van farmacologisch werkzame benzylideen- aminoguanidinederivaten. |
| FR169646A FR8343M (enrdf_load_stackoverflow) | 1967-10-13 | 1968-10-11 | |
| SE6813751A SE381041B (sv) | 1967-10-13 | 1968-10-11 | Forfarande for framstellning av aminoguanidiner |
| FI682889A FI49958C (fi) | 1967-10-13 | 1968-10-11 | Menetelmä terapeuttisesti aktiivisen aminoguanidiini-johdannaisen valm istamiseksi. |
| CA032,413A CA958018A (en) | 1967-10-13 | 1968-10-12 | Guanidines |
| CH1534368A CH560188A5 (enrdf_load_stackoverflow) | 1967-10-13 | 1968-10-14 | |
| IE1364/71A IE32853B1 (en) | 1968-02-22 | 1968-10-14 | Guanidines |
| CH119372A CH524577A (de) | 1967-10-13 | 1968-10-14 | Verfahren zur Herstellung von Aminoguanidinen |
| IE1223/68A IE32417B1 (en) | 1967-10-13 | 1968-10-14 | Guanidines |
| BR20654969A BR6906549D0 (pt) | 1968-02-22 | 1969-02-21 | Processo para a preparacao de guanidinas |
| CA115885A CA921829A (en) | 1967-10-13 | 1971-06-17 | Guanidines |
| IN1068/CAL/1975A IN141035B (enrdf_load_stackoverflow) | 1968-02-22 | 1975-05-27 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67502667A | 1967-10-13 | 1967-10-13 | |
| GB8629/68A GB1223491A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
| US75449468A | 1968-08-21 | 1968-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1223491A true GB1223491A (en) | 1971-02-24 |
Family
ID=27255238
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8629/68A Expired GB1223491A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
| GB39073/70A Expired GB1223492A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39073/70A Expired GB1223492A (en) | 1967-10-13 | 1968-02-22 | Guanidines |
Country Status (13)
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021120A1 (en) * | 1979-06-01 | 1981-01-07 | The Wellcome Foundation Limited | 3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
| EP0021121A1 (en) * | 1979-06-01 | 1981-01-07 | The Wellcome Foundation Limited | 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
| US4602041A (en) * | 1982-02-10 | 1986-07-22 | Beecham Group P.L.C. | Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses |
| EP0488897A1 (fr) * | 1990-11-29 | 1992-06-03 | Adir Et Compagnie | Nouveaux dérivés de guanidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| GB2277090A (en) * | 1993-04-16 | 1994-10-19 | Shell Int Research | Fungicidal tetrahydropyrimidine and imidazoline derivatives |
| WO1998023267A1 (en) * | 1996-11-26 | 1998-06-04 | Wapharm Ab | Use of hydroxyguanidines |
| WO2001025192A1 (en) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| WO2002081430A3 (en) * | 2001-04-05 | 2003-08-14 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| WO2008071980A1 (en) | 2006-12-14 | 2008-06-19 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands. |
| US8148429B2 (en) | 2000-08-07 | 2012-04-03 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
| WO2016162689A1 (en) * | 2015-04-08 | 2016-10-13 | Medical Research Council | Inhibitors and their uses |
| EP3109237A1 (en) * | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
| US10100020B2 (en) | 2013-01-10 | 2018-10-16 | United Kingdom Research And Innovation | Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases |
| EP3592147A4 (en) * | 2017-03-06 | 2020-12-16 | The United States of America as represented by the Secretary of Agriculture | SELF-ASSEMBLED ACTIVE AGENTS |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH523232A (de) * | 1968-12-16 | 1972-05-31 | Sandoz Ag | Verfahren zur Herstellung eines Benzylidenaminoguanidins |
| US4006249A (en) | 1975-08-06 | 1977-02-01 | American Home Products Corporation | Systemic treatment of psoriasis |
| DE10149919A1 (de) | 2001-10-10 | 2003-04-24 | Biosphings Ag | Neue Salze von Guanidinderivaten und pharmazeutische Zubereitungen daraus |
| FR2893844B1 (fr) * | 2005-11-28 | 2008-02-01 | Centre Nat Rech Scient | Utilisation du guanabenz et de ses derives pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE958832C (de) * | 1952-11-14 | 1957-02-28 | Bayer Ag | Verfahren zur Herstellung von Guanylhydrazonen |
| GB1019120A (en) * | 1964-03-18 | 1966-02-02 | Shell Int Research | Novel hydrazine compounds and compositions containing them |
-
1968
- 1968-02-22 GB GB8629/68A patent/GB1223491A/en not_active Expired
- 1968-02-22 GB GB39073/70A patent/GB1223492A/en not_active Expired
- 1968-09-29 IL IL30782A patent/IL30782A/en unknown
- 1968-10-04 IT IT22075/68A patent/IT1062053B/it active
- 1968-10-07 PH PH9625A patent/PH10262A/en unknown
- 1968-10-10 BE BE722136D patent/BE722136A/xx not_active IP Right Cessation
- 1968-10-10 DE DE1802394A patent/DE1802394C2/de not_active Expired
- 1968-10-11 NL NL6814608.A patent/NL166014C/xx not_active IP Right Cessation
- 1968-10-11 SE SE6813751A patent/SE381041B/xx unknown
- 1968-10-11 FI FI682889A patent/FI49958C/fi active
- 1968-10-11 DK DK492468AA patent/DK128350B/da not_active IP Right Cessation
- 1968-10-12 CA CA032,413A patent/CA958018A/en not_active Expired
- 1968-10-14 IE IE1223/68A patent/IE32417B1/xx unknown
- 1968-10-14 CH CH1534368A patent/CH560188A5/xx not_active IP Right Cessation
- 1968-10-14 CH CH119372A patent/CH524577A/de not_active IP Right Cessation
-
1971
- 1971-06-17 CA CA115885A patent/CA921829A/en not_active Expired
Cited By (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0021120A1 (en) * | 1979-06-01 | 1981-01-07 | The Wellcome Foundation Limited | 3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
| EP0021121A1 (en) * | 1979-06-01 | 1981-01-07 | The Wellcome Foundation Limited | 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them |
| EP0059987A1 (en) * | 1979-06-01 | 1982-09-15 | The Wellcome Foundation Limited | Alpha-cyano-alpha-((N-guanidino)-imino) toluenes |
| US4486354A (en) * | 1979-06-01 | 1984-12-04 | Baxter Martin G | Substituted aromatic compounds |
| US4560687A (en) * | 1979-06-01 | 1985-12-24 | Baxter Martin G | Substituted aromatic compounds |
| US4602017A (en) * | 1979-06-01 | 1986-07-22 | Sawyer David A | Substituted aromatic compounds |
| US4602041A (en) * | 1982-02-10 | 1986-07-22 | Beecham Group P.L.C. | Benzylideneamino- and phenylacetylguanidines and their pharmaceutical uses |
| EP0488897A1 (fr) * | 1990-11-29 | 1992-06-03 | Adir Et Compagnie | Nouveaux dérivés de guanidine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| FR2669927A1 (fr) * | 1990-11-29 | 1992-06-05 | Adir | Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB2277090A (en) * | 1993-04-16 | 1994-10-19 | Shell Int Research | Fungicidal tetrahydropyrimidine and imidazoline derivatives |
| WO1998023267A1 (en) * | 1996-11-26 | 1998-06-04 | Wapharm Ab | Use of hydroxyguanidines |
| US6599943B1 (en) | 1996-11-26 | 2003-07-29 | Wapharm Ab | Use of hydroxyguanidines |
| WO2001025192A1 (en) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| US8410174B2 (en) | 2000-08-07 | 2013-04-02 | Anamar Ab | Method for treating arthritis |
| US8148429B2 (en) | 2000-08-07 | 2012-04-03 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
| US8309609B2 (en) | 2000-08-07 | 2012-11-13 | Anamar Ab | Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands |
| US9227927B2 (en) | 2000-08-07 | 2016-01-05 | Anamar Ab | Method of treating inflammation |
| WO2002081430A3 (en) * | 2001-04-05 | 2003-08-14 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| WO2008071980A1 (en) | 2006-12-14 | 2008-06-19 | Acure Pharma Ab | Novel aminoguanidines as melanocortin receptor ligands. |
| US8372878B2 (en) | 2006-12-14 | 2013-02-12 | Anamar Ab | Aminoguanidines as melanocortin receptor ligands |
| US10954198B2 (en) | 2013-01-10 | 2021-03-23 | United Kingdom Research And Innovation | Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases |
| US10526297B2 (en) | 2013-01-10 | 2020-01-07 | Inflectis Bioscience | Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases |
| US10100020B2 (en) | 2013-01-10 | 2018-10-16 | United Kingdom Research And Innovation | Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases |
| WO2016162689A1 (en) * | 2015-04-08 | 2016-10-13 | Medical Research Council | Inhibitors and their uses |
| CN107709291A (zh) * | 2015-04-08 | 2018-02-16 | 医疗研究局 | 抑制剂及其应用 |
| US11331286B2 (en) | 2015-04-08 | 2022-05-17 | United Kingdom Research And Innovation | Inhibitors and their uses |
| US11337941B2 (en) | 2015-04-08 | 2022-05-24 | United Kingdom Research And Innovation | Inhibitors and their uses |
| US11154519B2 (en) | 2015-04-08 | 2021-10-26 | United Kingdom Research And Innovation | Inhibitors and their uses |
| US11364211B2 (en) | 2015-04-08 | 2022-06-21 | United Kingdom Research And Innovation | Methods for selecting phosphatase selective and non-selective phosphatase inhibitors |
| CN107787321A (zh) * | 2015-06-22 | 2018-03-09 | 安娜玛有限公司 | 新型5‑ht2拮抗剂 |
| US10544103B2 (en) | 2015-06-22 | 2020-01-28 | Anamar Ab | 5-HT2 antagonists |
| CN107787321B (zh) * | 2015-06-22 | 2021-10-01 | 安娜玛有限公司 | 新型5-ht2拮抗剂 |
| RU2706229C2 (ru) * | 2015-06-22 | 2019-11-15 | Анамар Аб | Новые антагонисты 5-нт2 |
| JP2018522829A (ja) * | 2015-06-22 | 2018-08-16 | アナマー アーベー | 新規の5−ht2アンタゴニスト |
| WO2016207231A1 (en) * | 2015-06-22 | 2016-12-29 | Anamar Ab | Novel 5-ht2 antagonists |
| EP3109237A1 (en) * | 2015-06-22 | 2016-12-28 | AnaMar AB | Novel 5-ht2 antagonists |
| EP3592147A4 (en) * | 2017-03-06 | 2020-12-16 | The United States of America as represented by the Secretary of Agriculture | SELF-ASSEMBLED ACTIVE AGENTS |
Also Published As
| Publication number | Publication date |
|---|---|
| IE32417B1 (en) | 1973-07-25 |
| CA921829A (en) | 1973-02-27 |
| IL30782A (en) | 1972-08-30 |
| IE32417L (en) | 1969-04-13 |
| DE1802394C2 (de) | 1984-06-28 |
| CH560188A5 (enrdf_load_stackoverflow) | 1975-03-27 |
| FI49958C (fi) | 1975-11-10 |
| CA958018A (en) | 1974-11-19 |
| SE381041B (sv) | 1975-11-24 |
| DE1802394A1 (de) | 1969-05-08 |
| BE722136A (enrdf_load_stackoverflow) | 1969-04-10 |
| CH524577A (de) | 1972-06-30 |
| FI49958B (enrdf_load_stackoverflow) | 1975-07-31 |
| IT1062053B (it) | 1983-06-25 |
| GB1223492A (en) | 1971-02-24 |
| NL6814608A (enrdf_load_stackoverflow) | 1969-04-15 |
| NL166014B (nl) | 1981-01-15 |
| DK128350B (da) | 1974-04-16 |
| NL166014C (nl) | 1981-06-15 |
| PH10262A (en) | 1976-10-20 |
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