GB1221257A - Salicylanilides and thiosalicylanilides - Google Patents

Salicylanilides and thiosalicylanilides

Info

Publication number
GB1221257A
GB1221257A GB5465968A GB5465968A GB1221257A GB 1221257 A GB1221257 A GB 1221257A GB 5465968 A GB5465968 A GB 5465968A GB 5465968 A GB5465968 A GB 5465968A GB 1221257 A GB1221257 A GB 1221257A
Authority
GB
United Kingdom
Prior art keywords
haloalkyl
isocyanate
nov
nitro
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5465968A
Inventor
Victor Joseph Grenda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1221257A publication Critical patent/GB1221257A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,221,257. Salicylanilides and thiosalicylanilides. MERCK & CO. Inc. 18 Nov., 1968 [22 Nov., 1967], No. 54659/68. Heading C2C. Therapeutic compounds (I): wherein each of Q and Z signify O or S, n is 0, 1, 2 or 3, Y is halogen, hydroxy, alkyl, haloalkyl, alkoxy or nitro, and X and X<SP>1</SP> signify halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cyano, nitro, haloalkylthio or hydroxy, are obtained by reacting an amine (II) with phosgene or thiophosgene and subsequently reacting the isocyanate or isothiocyanate III so formed with an appropriately substituted phenol or alkali or alkaline earth metal salt thereof; alternatively the isocyanate or isothiocyanate may be reacted with the phenol and the carbamate or thiocarbamate intermediate is then treated with a metal hydroxide, hydride or carbonate. Pharmaceutical preparations effective against liver fluke contain compounds I as active ingredient; administration may be orally or by injection.
GB5465968A 1967-11-22 1968-11-18 Salicylanilides and thiosalicylanilides Expired GB1221257A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68496767A 1967-11-22 1967-11-22

Publications (1)

Publication Number Publication Date
GB1221257A true GB1221257A (en) 1971-02-03

Family

ID=24750249

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5465968A Expired GB1221257A (en) 1967-11-22 1968-11-18 Salicylanilides and thiosalicylanilides

Country Status (6)

Country Link
BR (1) BR6804170D0 (en)
DE (1) DE1808681A1 (en)
DK (1) DK127553B (en)
ES (1) ES360381A1 (en)
GB (1) GB1221257A (en)
NL (1) NL6815873A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ297581B6 (en) * 2005-05-26 2007-01-10 Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Antimycotic and antimycobacterial thiosalicylanilides and process of their preparation
CZ298498B6 (en) * 2005-05-26 2007-10-17 Universita Karlova v Praze, Farmaceutická fakultav Hradci Králové Process for preparing thiosalicyl amides in particular thiosalicyl anilides

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1226041B (en) * 1965-05-07 1966-09-29 Esterer A G Maschf Device for transporting long goods
NL7012496A (en) * 1969-09-08 1971-03-10
JPS60204250A (en) * 1984-03-26 1985-10-15 Toshiba Corp Conveying apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ297581B6 (en) * 2005-05-26 2007-01-10 Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Antimycotic and antimycobacterial thiosalicylanilides and process of their preparation
CZ298498B6 (en) * 2005-05-26 2007-10-17 Universita Karlova v Praze, Farmaceutická fakultav Hradci Králové Process for preparing thiosalicyl amides in particular thiosalicyl anilides

Also Published As

Publication number Publication date
DK127553B (en) 1973-11-26
ES360381A1 (en) 1970-07-01
DE1808681A1 (en) 1969-07-17
NL6815873A (en) 1969-05-27
BR6804170D0 (en) 1973-01-16

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