GB1220591A - Beta-phenylalanine derivatives - Google Patents
Beta-phenylalanine derivativesInfo
- Publication number
- GB1220591A GB1220591A GB24754/67A GB2475467A GB1220591A GB 1220591 A GB1220591 A GB 1220591A GB 24754/67 A GB24754/67 A GB 24754/67A GB 2475467 A GB2475467 A GB 2475467A GB 1220591 A GB1220591 A GB 1220591A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- hydroxy
- general formula
- acid
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UJOYFRCOTPUKAK-MRVPVSSYSA-N (R)-3-ammonio-3-phenylpropanoate Chemical class OC(=O)C[C@@H](N)C1=CC=CC=C1 UJOYFRCOTPUKAK-MRVPVSSYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 231100000252 nontoxic Toxicity 0.000 abstract 5
- 230000003000 nontoxic effect Effects 0.000 abstract 5
- -1 2-benzyl-2- amino-malonic acid ester Chemical class 0.000 abstract 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical class CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- GVSGSHGXUXLQNS-UHFFFAOYSA-N 3-bromo-4,5-dihydroxybenzaldehyde Chemical compound OC1=CC(C=O)=CC(Br)=C1O GVSGSHGXUXLQNS-UHFFFAOYSA-N 0.000 abstract 2
- OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 2
- BTNMPGBKDVTSJY-UHFFFAOYSA-N keto-phenylpyruvic acid Chemical class OC(=O)C(=O)CC1=CC=CC=C1 BTNMPGBKDVTSJY-UHFFFAOYSA-N 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- OQBSVOPJNGVTQT-VIFPVBQESA-N (2S)-2-acetamido-3-(3-bromo-4-hydroxy-5-methoxyphenyl)propanoic acid Chemical compound COC=1C=C(C[C@H](NC(C)=O)C(=O)O)C=C(C1O)Br OQBSVOPJNGVTQT-VIFPVBQESA-N 0.000 abstract 1
- IEJPPSMHUUQABK-UHFFFAOYSA-N 2,4-diphenyl-4h-1,3-oxazol-5-one Chemical compound O=C1OC(C=2C=CC=CC=2)=NC1C1=CC=CC=C1 IEJPPSMHUUQABK-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 238000006114 decarboxylation reaction Methods 0.000 abstract 1
- JHLAYRZOCXOWLL-UHFFFAOYSA-N diethyl 2-acetamido-2-[(3-chloro-4,5-dihydroxyphenyl)methyl]propanedioate Chemical compound C(C)OC(C(C(=O)OCC)(CC1=CC(=C(C(=C1)Cl)O)O)NC(C)=O)=O JHLAYRZOCXOWLL-UHFFFAOYSA-N 0.000 abstract 1
- AKQHJNSAQJHSCZ-UHFFFAOYSA-N diethyl 2-acetamido-2-[(3-chloro-4-hydroxy-5-methoxyphenyl)methyl]propanedioate Chemical compound C(C)(=O)NC(C(=O)OCC)(C(=O)OCC)CC1=CC(=C(C(=C1)Cl)O)OC AKQHJNSAQJHSCZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Chemical group 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24754/67A GB1220591A (en) | 1967-05-26 | 1967-05-26 | Beta-phenylalanine derivatives |
DE19681768466 DE1768466A1 (de) | 1967-05-26 | 1968-05-16 | Neue ss-Phenylalanin-Derivate |
ES354058A ES354058A1 (es) | 1967-05-26 | 1968-05-18 | Un procedimiento para producir un derivado de dl- d- o l- beta-fenilalamina. |
CH769568A CH515888A (fr) | 1967-05-26 | 1968-05-24 | Procédé pour la préparation de dérivés de la bêta-phénylalanine |
CH95170A CH517700A (fr) | 1967-05-26 | 1968-05-24 | Procédé pour la préparation de dérivés de la bêta-phénylalanine |
AT499368A AT286968B (de) | 1967-05-26 | 1968-05-24 | Verfahren zur Herstellung von neuen DL-, D- und L-β-Phenylalaninderivaten |
BE715588D BE715588A (enrdf_load_stackoverflow) | 1967-05-26 | 1968-05-24 | |
NO204168A NO121788B (enrdf_load_stackoverflow) | 1967-05-26 | 1968-05-24 | |
NL6807465A NL6807465A (enrdf_load_stackoverflow) | 1967-05-26 | 1968-05-27 | |
FR153043A FR7889M (enrdf_load_stackoverflow) | 1967-05-26 | 1968-05-27 | |
FR1592518D FR1592518A (enrdf_load_stackoverflow) | 1967-05-26 | 1968-05-27 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24754/67A GB1220591A (en) | 1967-05-26 | 1967-05-26 | Beta-phenylalanine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1220591A true GB1220591A (en) | 1971-01-27 |
Family
ID=10216725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24754/67A Expired GB1220591A (en) | 1967-05-26 | 1967-05-26 | Beta-phenylalanine derivatives |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT286968B (enrdf_load_stackoverflow) |
BE (1) | BE715588A (enrdf_load_stackoverflow) |
CH (1) | CH515888A (enrdf_load_stackoverflow) |
DE (1) | DE1768466A1 (enrdf_load_stackoverflow) |
ES (1) | ES354058A1 (enrdf_load_stackoverflow) |
FR (2) | FR7889M (enrdf_load_stackoverflow) |
GB (1) | GB1220591A (enrdf_load_stackoverflow) |
NL (1) | NL6807465A (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004110500A1 (en) * | 2002-08-02 | 2004-12-23 | Mallinckrodt Inc. | Radioactively labelled amino acid analogues, their preparation and use |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE789586A (fr) * | 1972-03-27 | 1973-04-02 | Hoffmann La Roche | Procede pour la preparation de 3,4,5-trimethoxy-benzaldehyde |
-
1967
- 1967-05-26 GB GB24754/67A patent/GB1220591A/en not_active Expired
-
1968
- 1968-05-16 DE DE19681768466 patent/DE1768466A1/de active Pending
- 1968-05-18 ES ES354058A patent/ES354058A1/es not_active Expired
- 1968-05-24 AT AT499368A patent/AT286968B/de not_active IP Right Cessation
- 1968-05-24 CH CH769568A patent/CH515888A/fr not_active IP Right Cessation
- 1968-05-24 BE BE715588D patent/BE715588A/xx unknown
- 1968-05-27 NL NL6807465A patent/NL6807465A/xx unknown
- 1968-05-27 FR FR153043A patent/FR7889M/fr not_active Expired
- 1968-05-27 FR FR1592518D patent/FR1592518A/fr not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004110500A1 (en) * | 2002-08-02 | 2004-12-23 | Mallinckrodt Inc. | Radioactively labelled amino acid analogues, their preparation and use |
US7189383B2 (en) | 2002-08-02 | 2007-03-13 | Mallinckrodt Inc. | Radioactively labelled amino acid analogues, their preparation and use |
AU2003304200B2 (en) * | 2002-08-02 | 2009-10-01 | Vrije Universiteit Brussel | Radioactively labelled amino acid analogues, their preparation and use |
Also Published As
Publication number | Publication date |
---|---|
AT286968B (de) | 1971-01-11 |
FR7889M (enrdf_load_stackoverflow) | 1970-05-04 |
DE1768466A1 (de) | 1971-09-16 |
ES354058A1 (es) | 1970-02-16 |
NL6807465A (enrdf_load_stackoverflow) | 1968-11-27 |
CH515888A (fr) | 1971-11-30 |
FR1592518A (enrdf_load_stackoverflow) | 1970-05-19 |
BE715588A (enrdf_load_stackoverflow) | 1968-10-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1432576A (en) | Substituted phenylacetic acids | |
GB1017439A (en) | New amino-acids and process for preparing same | |
GB866184A (en) | Tri-iodo-benzoic acid derivatives | |
GB1237008A (en) | Novel indoline derivatives | |
GB1355681A (en) | Phenylacetic acid derivatives | |
CH613449A5 (en) | Process for the preparation of novel indole derivatives | |
GB1467110A (en) | 4-phenyl-5-oxo-heptenoic acids | |
GB1277239A (en) | Cycloalkane-carboxylic acid derivatives | |
GB1454312A (en) | 4-oxo-6,7,8,9-tetrahydropyrido-1,2-a-pyrimidine derivatives methods for their preparation and compositions containing them | |
GB1220591A (en) | Beta-phenylalanine derivatives | |
GB1277789A (en) | Improvements in or relating to new polycyclic pyrrole derivatives | |
GB1288647A (enrdf_load_stackoverflow) | ||
GB1273705A (en) | A method for producing 3,5-diaryl-4-pyrazole acetic acids | |
GB1174349A (en) | Novel 2-Anilinomethylimidazoline Derivatives and process for the preparation thereof | |
GB1291644A (en) | Substituted 1-indancarboxylic acids, their esters and salts | |
ES338709A1 (es) | Un procedimiento de preparar derivados de isoquinoleina. | |
GB1461876A (en) | Alpha-1-aralkylaminoalkyl-aralkoxybenzyl alcohols process for their manufacture and pharamaceutical preparations con taining them | |
GB1307284A (en) | 2-substituted phenyl propionic acids | |
GB1195491A (en) | 4-Substituted 7- and 8-Chloroquinolines, the Preparation thereof, and Compositions Containing the same | |
GB1397434A (en) | Evomonoside derivatives | |
GB1310606A (en) | Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them | |
GB1274265A (en) | Dibenzocycloheptene derivatives | |
GB1147832A (en) | Fluorene xanthene and thioxanthene derivatives | |
GB1219387A (en) | Bicyclo[2.2.2]oct-2-ene-amino acid compounds | |
GB1334125A (en) | Aminopropionanilides and a process for the preparation thereof |