GB1214408A - 3,5-diamino-6-halo-pyrazinamide derivatives - Google Patents
3,5-diamino-6-halo-pyrazinamide derivativesInfo
- Publication number
- GB1214408A GB1214408A GB41777/68A GB4177768A GB1214408A GB 1214408 A GB1214408 A GB 1214408A GB 41777/68 A GB41777/68 A GB 41777/68A GB 4177768 A GB4177768 A GB 4177768A GB 1214408 A GB1214408 A GB 1214408A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- phenyl
- group
- alkoxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 53
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- -1 cyano, amino Chemical group 0.000 abstract 6
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 5
- 125000005059 halophenyl group Chemical group 0.000 abstract 5
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66600467A | 1967-09-07 | 1967-09-07 | |
| US71897668A | 1968-03-21 | 1968-03-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1214408A true GB1214408A (en) | 1970-12-02 |
Family
ID=27099350
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41777/68A Expired GB1214408A (en) | 1967-09-07 | 1968-09-03 | 3,5-diamino-6-halo-pyrazinamide derivatives |
| GB53830/69A Expired GB1214409A (en) | 1967-09-07 | 1968-09-03 | Novel pyrazine derivatives and their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB53830/69A Expired GB1214409A (en) | 1967-09-07 | 1968-09-03 | Novel pyrazine derivatives and their preparation |
Country Status (15)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013064451A1 (en) * | 2011-11-02 | 2013-05-10 | Boehringer Ingelheim International Gmbh | Novel process for the preparation of acylguanidines and acylthioureas |
| US8759349B2 (en) | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| US8841309B2 (en) | 2012-09-24 | 2014-09-23 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| US9078909B2 (en) | 2012-05-25 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
-
1968
- 1968-08-22 NL NL6812003A patent/NL6812003A/xx unknown
- 1968-08-26 IL IL30634A patent/IL30634A0/xx unknown
- 1968-08-28 FI FI682412A patent/FI50975C/fi active
- 1968-08-30 BE BE720233D patent/BE720233A/xx unknown
- 1968-08-31 CA CA028,994A patent/CA939345A/en not_active Expired
- 1968-09-02 YU YU02052/68A patent/YU205268A/xx unknown
- 1968-09-03 GB GB41777/68A patent/GB1214408A/en not_active Expired
- 1968-09-03 GB GB53830/69A patent/GB1214409A/en not_active Expired
- 1968-09-04 OA OA53362A patent/OA02886A/xx unknown
- 1968-09-05 SE SE11956/68A patent/SE355811B/xx unknown
- 1968-09-05 ES ES357877A patent/ES357877A1/es not_active Expired
- 1968-09-06 CH CH1340268A patent/CH534168A/de not_active IP Right Cessation
- 1968-09-06 AT AT872468A patent/AT289123B/de not_active IP Right Cessation
- 1968-09-06 DK DK429268A patent/DK145892C/da active
- 1968-09-06 NO NO3467/68A patent/NO125678B/no unknown
- 1968-12-06 FR FR176992A patent/FR8490M/fr not_active Expired
-
1969
- 1969-09-02 YU YU2052/68A patent/YU34082B/xx unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013064451A1 (en) * | 2011-11-02 | 2013-05-10 | Boehringer Ingelheim International Gmbh | Novel process for the preparation of acylguanidines and acylthioureas |
| US8759349B2 (en) | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| US8791260B2 (en) | 2011-11-02 | 2014-07-29 | Boehringer Ingelheim International Gmbh | Process for the preparation of acylguanidines and acylthioureas |
| CN104024231A (zh) * | 2011-11-02 | 2014-09-03 | 勃林格殷格翰国际有限公司 | 制备酰基胍和酰基硫脲化合物的新方法 |
| US9920035B2 (en) | 2011-11-02 | 2018-03-20 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| US8859559B2 (en) | 2011-12-20 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
| US9078909B2 (en) | 2012-05-25 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Tertiary amines, medicaments containing said amines, use thereof and processes for the preparation thereof |
| US8841309B2 (en) | 2012-09-24 | 2014-09-23 | Boehringer Ingelheim International Gmbh | Substituted pyrazines and their use in the treatment of disease |
Also Published As
| Publication number | Publication date |
|---|---|
| FI50975C (fi) | 1976-09-10 |
| CH534168A (de) | 1973-02-28 |
| NL6812003A (enrdf_load_stackoverflow) | 1969-03-11 |
| IL30634A0 (en) | 1968-10-24 |
| FR8490M (enrdf_load_stackoverflow) | 1973-07-27 |
| YU205268A (en) | 1978-06-30 |
| BE720233A (enrdf_load_stackoverflow) | 1969-02-28 |
| GB1214409A (en) | 1970-12-02 |
| OA02886A (fr) | 1970-12-15 |
| YU34082B (en) | 1978-12-31 |
| DK145892C (da) | 1983-09-12 |
| SE355811B (enrdf_load_stackoverflow) | 1973-05-07 |
| ES357877A1 (es) | 1970-05-01 |
| NO125678B (enrdf_load_stackoverflow) | 1972-10-16 |
| FI50975B (enrdf_load_stackoverflow) | 1976-05-31 |
| DK145892B (da) | 1983-04-05 |
| CA939345A (en) | 1974-01-01 |
| AT289123B (de) | 1971-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |