GB1201269A - 2-substituted-4(5)-nitroimidazoles - Google Patents

2-substituted-4(5)-nitroimidazoles

Info

Publication number
GB1201269A
GB1201269A GB5831667A GB5831667A GB1201269A GB 1201269 A GB1201269 A GB 1201269A GB 5831667 A GB5831667 A GB 5831667A GB 5831667 A GB5831667 A GB 5831667A GB 1201269 A GB1201269 A GB 1201269A
Authority
GB
United Kingdom
Prior art keywords
nitroimidazoles
substituted
imidazole derivatives
alkylimidazoles
comptroller
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5831667A
Inventor
Janos Kollonitsch
Alan Newton Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1201269A publication Critical patent/GB1201269A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,201,269. Imidazole derivatives. MERCK & CO. Inc. 22 Dec., 1967 [6 Jan., 1967], No. 58316/67. Heading C2C. Novel imidazole derivatives of the formula wherein R 1 is H or NO 2 and R is C 1-3 alkyl or H are prepared by chlorinating the appropriate 2-alkylimidazoles, and, if desired, nitrating the resulting 2-(α-chloroalkyl)-imidazoles. Reference has been directed by the Comptroller to Specification 1,123,049.
GB5831667A 1967-01-06 1967-12-22 2-substituted-4(5)-nitroimidazoles Expired GB1201269A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60764267A 1967-01-06 1967-01-06

Publications (1)

Publication Number Publication Date
GB1201269A true GB1201269A (en) 1970-08-05

Family

ID=24433101

Family Applications (2)

Application Number Title Priority Date Filing Date
GB5831667A Expired GB1201269A (en) 1967-01-06 1967-12-22 2-substituted-4(5)-nitroimidazoles
GB4271569A Expired GB1201270A (en) 1967-01-06 1967-12-22 Imidazole derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4271569A Expired GB1201270A (en) 1967-01-06 1967-12-22 Imidazole derivatives

Country Status (4)

Country Link
CH (1) CH496709A (en)
FR (1) FR1588786A (en)
GB (2) GB1201269A (en)
NL (1) NL6717043A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006463A1 (en) * 1978-06-22 1980-01-09 BASF Aktiengesellschaft Process for the production of 2-substituted 1-alkyl-nitroimidazoles
EP0219947A2 (en) * 1985-08-28 1987-04-29 Merck & Co. Inc. Use of 1-methyl-2-methylsulphonyl-4-nitroimidazole as an antiprotozoal and antibacterial agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006463A1 (en) * 1978-06-22 1980-01-09 BASF Aktiengesellschaft Process for the production of 2-substituted 1-alkyl-nitroimidazoles
EP0219947A2 (en) * 1985-08-28 1987-04-29 Merck & Co. Inc. Use of 1-methyl-2-methylsulphonyl-4-nitroimidazole as an antiprotozoal and antibacterial agent
EP0219947A3 (en) * 1985-08-28 1989-07-26 Merck & Co. Inc. Use of 1-methyl-2-methylsulphonyl-4-nitroimidazole as an antiprotozoal and antibacterial agent

Also Published As

Publication number Publication date
NL6717043A (en) 1968-07-08
CH496709A (en) 1970-09-30
GB1201270A (en) 1970-08-05
FR1588786A (en) 1970-03-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees