GB1200966A - Method and apparatus for fluid handling and separation - Google Patents

Method and apparatus for fluid handling and separation

Info

Publication number
GB1200966A
GB1200966A GB33872/68A GB3387268A GB1200966A GB 1200966 A GB1200966 A GB 1200966A GB 33872/68 A GB33872/68 A GB 33872/68A GB 3387268 A GB3387268 A GB 3387268A GB 1200966 A GB1200966 A GB 1200966A
Authority
GB
United Kingdom
Prior art keywords
bung
tube
blood
centrifugal force
layers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33872/68A
Inventor
Charles Mosby Coleman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1200966A publication Critical patent/GB1200966A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Centrifugal Separators (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

1,200,966. Separating liquids; centrifugal separation. C. M. COLEMAN. 16 July, 1968 [17 Nov., 1967], No. 33872/68. Headings B1D and B2P. [Also in Divisions A5 and B8. Liquid layers 42, 44 (e.g. blood cells and plasma) in a tube 40 are sealed apart by means of a resilient bung 46 which is forced downwardly through layer 44 (the displaced liquid passing around or through the bung) until it arrives at the interlayer boundary. As described, a blood sample is centrifuged or allowed to settle into two phases, and then the tube is subjected to a stronger centrifugal force to cause bung 46, originally secured to a stopper 48, to sever therefrom and commence its downward journey. In another embodiment, Figs. 8, 8A (not shown) the displaced upper phase 44 may pass through the bung via a passageway 82 incorporating a valve. In Figs. 2-4 (not shown) the bung is moved downwardly, not by a centrifugal force, but directly by a plunger (30). Preferably the density of the bung is intermediate that of the blood layers, (i.e. 1.045-1.090) so that it automatically stops at the interphase boundary during centrifuging.
GB33872/68A 1967-11-17 1968-07-16 Method and apparatus for fluid handling and separation Expired GB1200966A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68391667A 1967-11-17 1967-11-17

Publications (1)

Publication Number Publication Date
GB1200966A true GB1200966A (en) 1970-08-05

Family

ID=24745992

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33872/68A Expired GB1200966A (en) 1967-11-17 1968-07-16 Method and apparatus for fluid handling and separation

Country Status (6)

Country Link
US (1) US3508653A (en)
JP (1) JPS5018398B1 (en)
BE (1) BE727162A (en)
BR (1) BR6804008D0 (en)
FR (1) FR1578472A (en)
GB (1) GB1200966A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51101195U (en) * 1975-02-12 1976-08-13
JPS51105890A (en) * 1974-08-09 1976-09-20 Becton Dickinson Co

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US3647070A (en) * 1970-06-11 1972-03-07 Technicon Corp Method and apparatus for the provision of fluid interface barriers
US3741400A (en) * 1970-06-15 1973-06-26 J Dick Blood sample container
US3799342A (en) * 1970-07-27 1974-03-26 Medical Res & Dev Inc Method of using a serum separator
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US3800947A (en) * 1971-07-16 1974-04-02 P Smith Reagent tube and centrifugally operated solid-liquid separating device
US3814248A (en) * 1971-09-07 1974-06-04 Corning Glass Works Method and apparatus for fluid collection and/or partitioning
US3849072A (en) * 1972-04-25 1974-11-19 Becton Dickinson Co Plasma separator
US3779383A (en) * 1972-04-25 1973-12-18 Becton Dickinson Co Sealed assembly for separation of blood components and method
US3788483A (en) * 1972-05-26 1974-01-29 W Conway Apparatus for filtration
US3780935A (en) * 1972-07-10 1973-12-25 Lukacs & Jacoby Ass Serum separating method
US3852194A (en) * 1972-12-11 1974-12-03 Corning Glass Works Apparatus and method for fluid collection and partitioning
US3786985A (en) * 1973-01-05 1974-01-22 Hoffmann La Roche Blood collection container
US3850174A (en) * 1973-03-14 1974-11-26 Becton Dickinson Co Plasma separator assembly
US3890954A (en) * 1973-05-08 1975-06-24 U S Medical Research & Dev Inc Method of and apparatus for collecting cultures
US4014746A (en) * 1973-05-08 1977-03-29 U.S. Medical Research And Development, Inc. Method of and apparatus for collecting cultures
US4409988A (en) * 1973-05-08 1983-10-18 Donald J. Greenspan Apparatus for collecting cultures
JPS542710Y2 (en) * 1973-08-03 1979-02-05
JPS542120B2 (en) * 1973-08-10 1979-02-02
US3879295A (en) * 1973-08-17 1975-04-22 Eastman Kodak Co Vacutainer with positive separation barrier
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
SE384274B (en) * 1973-11-27 1976-04-26 Stille Werner Ab SERUM SEPARATOR
US3941699A (en) * 1974-02-27 1976-03-02 Becton, Dickinson And Company Plasma separator with centrifugal valve
US3887464A (en) * 1974-02-27 1975-06-03 Becton Dickinson Co Serum/plasma separator with centrifugal valve seal
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
US3882021A (en) * 1974-02-27 1975-05-06 Becton Dickinson Co Sealed assembly for separation of blood with anti-red cell barrier
US3945928A (en) * 1974-02-27 1976-03-23 Becton, Dickinson And Company Serum/plasma separators with centrifugal valves
US3862042A (en) * 1974-02-27 1975-01-21 Becton Dickinson Co Serum/plasma separator - piston with red-cell trapping surfaces
US3919085A (en) * 1974-02-27 1975-11-11 Becton Dickinson Co Plasma separator assembly
US3935113A (en) * 1974-02-27 1976-01-27 Becton, Dickinson And Company Serum/plasma separator with centrifugal valve
US3891553A (en) * 1974-02-27 1975-06-24 Becton Dickinson Co Serum and plasma separator {13 {0 constrictionless type
US3897343A (en) * 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator-hydrostatic pressure type
US3890237A (en) * 1974-02-27 1975-06-17 Becton Dickinson Co Plasma separator {13 {0 cord stop type
US3920549A (en) * 1974-03-18 1975-11-18 Corning Glass Works Method and apparatus for multiphase fluid collection and separation
US3932277A (en) * 1974-03-29 1976-01-13 Bio-Logics Products, Inc. Method and apparatus for separating blood fractions
US3929646A (en) * 1974-07-22 1975-12-30 Technicon Instr Serum separator and fibrin filter
US3901219A (en) * 1974-07-25 1975-08-26 Becton Dickinson Co Blood collecting container and method
US3960727A (en) * 1974-08-09 1976-06-01 Hochstrasser Harry T Apparatus and method for isolating soluble blood components
US3972812A (en) * 1975-05-08 1976-08-03 Becton, Dickinson And Company Blood serum separation filter disc
US4083788A (en) * 1975-11-19 1978-04-11 Ferrara Louis T Blood serum-isolation device
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination
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AT381466B (en) * 1977-03-16 1986-10-27 Ballies Uwe SEPARATING TUBES FOR CENTRIFUGAL SEPARATION
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US4119125A (en) * 1977-06-22 1978-10-10 Elkins Carlos D Method and apparatus for handling liquid samples
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US4443345A (en) * 1982-06-28 1984-04-17 Wells John R Serum preparator
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51105890A (en) * 1974-08-09 1976-09-20 Becton Dickinson Co
JPS51101195U (en) * 1975-02-12 1976-08-13
JPS5533232Y2 (en) * 1975-02-12 1980-08-07

Also Published As

Publication number Publication date
BR6804008D0 (en) 1973-05-10
US3508653A (en) 1970-04-28
BE727162A (en) 1969-07-22
FR1578472A (en) 1969-08-14
DE1806196A1 (en) 1969-07-03
JPS5018398B1 (en) 1975-06-28
DE1806196B2 (en) 1972-08-31

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