GB1198690A - Improvements in or relating to New Biguanides - Google Patents

Improvements in or relating to New Biguanides

Info

Publication number
GB1198690A
GB1198690A GB51727/67A GB5172767A GB1198690A GB 1198690 A GB1198690 A GB 1198690A GB 51727/67 A GB51727/67 A GB 51727/67A GB 5172767 A GB5172767 A GB 5172767A GB 1198690 A GB1198690 A GB 1198690A
Authority
GB
United Kingdom
Prior art keywords
biguanides
nhcn
trifluoromethylphenyl
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB51727/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAB LAROCHE NAVARRON
Original Assignee
LAB LAROCHE NAVARRON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAB LAROCHE NAVARRON filed Critical LAB LAROCHE NAVARRON
Publication of GB1198690A publication Critical patent/GB1198690A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,198,690. Biguanides. LABORATOIRES LAROCHE NAVARRON. 14 Nov., 1967 [10 Aug., 1967], No. 51727/67. Heading C2C. The invention comprises compounds of formula and their acid addition salts, wherein Ar is trifluoromethylphenyl (optionally further halogenated) and R<SP>1</SP>, R<SP>2</SP> are each H or C 1-12 alkyl (but R<SP>1</SP> and R<SP>2</SP> cannot both be H when Ar is trifluoromethylphenyl); or R<SP>1</SP> is H and R<SP>2</SP> is cyclohexyl, pyridyl, pyrimidyl, quinolyl or thiazolyl, or phenyl or naphthyl which may be substituted by halogen, C 1-12 -alkyl or -alkoxy, alkylthio, trihaloalkyl or nitro; or NR<SP>1</SP>R<SP>2</SP> is pyrrolidinyl, piperidyl, morpholinyl or #<SP>2-</SP> pyrrolinyl. These compounds are prepared by reacting ArNHC(: NH)NHCN or NH 2 C(: NH) NHCN with ArNH 2 or R<SP>1</SP>R<SP>2</SP>NH. Therapeutic compositions for oral or rectal administration comprise biguanides of the above general formula, which have a blood-sugar reducing and anorexant activity, and a pharmaceutical excipient.
GB51727/67A 1967-08-10 1967-11-14 Improvements in or relating to New Biguanides Expired GB1198690A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR117480A FR6786M (en) 1967-08-10 1967-08-10

Publications (1)

Publication Number Publication Date
GB1198690A true GB1198690A (en) 1970-07-15

Family

ID=8636682

Family Applications (1)

Application Number Title Priority Date Filing Date
GB51727/67A Expired GB1198690A (en) 1967-08-10 1967-11-14 Improvements in or relating to New Biguanides

Country Status (4)

Country Link
BE (1) BE705859A (en)
DE (1) DE1693036B2 (en)
FR (1) FR6786M (en)
GB (1) GB1198690A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086563A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Diabetes imaging probes
WO2013022278A2 (en) 2011-08-08 2013-02-14 Hanall Biopharma Co., Ltd. N1-cyclic amine-n5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2009743A1 (en) * 1970-03-03 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Substituted biguanides with antihyperglycemic effects
ES403081A1 (en) * 1971-10-14 1976-01-01 Rorer Inc William H 1-phenyl biguanides and a process for their production
BE790130A (en) * 1971-10-18 1973-04-16 Ile De France NEW BIGUANIDES AND THEIR PREPARATION PROCESS

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086563A2 (en) * 2002-04-11 2003-10-23 Carbomer, Inc. Diabetes imaging probes
WO2003086563A3 (en) * 2002-04-11 2004-03-18 Carbomer Inc Diabetes imaging probes
US6911457B2 (en) 2002-04-11 2005-06-28 Carbomer, Inc. Diabetes imaging probes
WO2013022278A2 (en) 2011-08-08 2013-02-14 Hanall Biopharma Co., Ltd. N1-cyclic amine-n5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same
US9540325B2 (en) 2011-08-08 2017-01-10 ImmunoMet Therapeutics, Inc. N1-cyclic amine-N5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same
EP2742019B1 (en) * 2011-08-08 2021-03-03 Immunomet Therapeutics Inc. N1-cyclic amine-n5-substituted phenyl biguanide derivatives and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
DE1693036B2 (en) 1976-05-26
BE705859A (en) 1968-03-01
DE1693036A1 (en) 1972-02-17
FR6786M (en) 1969-03-17

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
435 Patent endorsed 'licences of right' on the date specified (sect. 35/1949)
PCNP Patent ceased through non-payment of renewal fee