GB1184422A - Antibiotic Granaticin B and Process for its Manufacture - Google Patents
Antibiotic Granaticin B and Process for its ManufactureInfo
- Publication number
- GB1184422A GB1184422A GB797467A GB797467A GB1184422A GB 1184422 A GB1184422 A GB 1184422A GB 797467 A GB797467 A GB 797467A GB 797467 A GB797467 A GB 797467A GB 1184422 A GB1184422 A GB 1184422A
- Authority
- GB
- United Kingdom
- Prior art keywords
- granaticin
- log
- antibiotic
- ester
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HLNZYALGGXMQQC-VHAJSWNUSA-N (1R,7S,11S,13S,19S,20R,23R)-3,17,19-trihydroxy-23-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-13,20-dimethyl-8,12,21-trioxahexacyclo[17.2.2.02,18.04,16.06,14.07,11]tricosa-2(18),3,6(14),16-tetraene-5,9,15-trione Chemical compound C[C@@H]1O[C@H](CC[C@@H]1O)O[C@@H]2C[C@H]3O[C@H](C)[C@@]2(O)c4c(O)c5C(=O)C6=C([C@@H]7OC(=O)C[C@@H]7O[C@H]6C)C(=O)c5c(O)c34 HLNZYALGGXMQQC-VHAJSWNUSA-N 0.000 title abstract 7
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- XXIHHRIZGBRENI-WDSKDSINSA-N L-rhodinose Chemical compound C[C@H](O)[C@@H](O)CCC=O XXIHHRIZGBRENI-WDSKDSINSA-N 0.000 abstract 2
- -1 alkanoyl ester Chemical class 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- KXKAQNZWMODXGL-UHFFFAOYSA-N Granaticin Natural products CC1OC(=CC2=C1C(=O)c3c(O)c4c(C5CC(O)C4(O)C(C)O5)c(O)c3C2=O)CC(=O)O KXKAQNZWMODXGL-UHFFFAOYSA-N 0.000 abstract 1
- 241000187176 Streptomyces violaceoruber Species 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- ONQCWTVJMHJRFM-LHKCJDRRSA-N granaticin Chemical compound C[C@H]([C@@]1(O)[C@@H](C2)O)O[C@H]2C(C2=O)=C1C(=O)C1=C2C(O)=C2[C@@H]3OC(=O)C[C@@H]3O[C@@H](C)C2=C1O ONQCWTVJMHJRFM-LHKCJDRRSA-N 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- GDVBLRJUTKZHGS-SYWFMFOKSA-N tetraacetylgranaticin Chemical compound C1[C@@H](OC(C)=O)[C@]2(OC(C)=O)C(C(OC(C)=O)=C3C(=O)C4=C(C(C3=C3OC(C)=O)=O)[C@@H]5OC(=O)C[C@@H]5O[C@H]4C)=C3[C@@H]1O[C@@H]2C GDVBLRJUTKZHGS-SYWFMFOKSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH251066A CH476102A (de) | 1966-02-22 | 1966-02-22 | Verfahren zur Herstellung eines neuen Antibiotikums |
| CH118667 | 1967-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1184422A true GB1184422A (en) | 1970-03-18 |
Family
ID=25686928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB797467A Expired GB1184422A (en) | 1966-02-22 | 1967-02-20 | Antibiotic Granaticin B and Process for its Manufacture |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE694385A (enrdf_load_stackoverflow) |
| DE (1) | DE1617396A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1184422A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3338770A1 (en) * | 2010-03-08 | 2018-06-27 | Sloan Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
-
1967
- 1967-02-20 GB GB797467A patent/GB1184422A/en not_active Expired
- 1967-02-21 DE DE19671617396 patent/DE1617396A1/de active Pending
- 1967-02-21 BE BE694385D patent/BE694385A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3338770A1 (en) * | 2010-03-08 | 2018-06-27 | Sloan Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
| US10123992B2 (en) | 2010-03-08 | 2018-11-13 | Sloan-Kettering Institute For Cancer Research | CDC7 kinase inhibitors and uses thereof |
| US11045446B2 (en) | 2010-03-08 | 2021-06-29 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
| US11666550B2 (en) | 2010-03-08 | 2023-06-06 | Sloan-Kettering Institute For Cancer Research | CDC7 kinase inhibitors and uses thereof |
| US12109189B2 (en) | 2010-03-08 | 2024-10-08 | Sloan-Kettering Institute For Cancer Research | CDC7 kinase inhibitors and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1617396A1 (de) | 1971-04-08 |
| BE694385A (enrdf_load_stackoverflow) | 1967-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |