GB1178400A - Nitrogen Substituted Amines and their process of Preparation. - Google Patents
Nitrogen Substituted Amines and their process of Preparation.Info
- Publication number
- GB1178400A GB1178400A GB55671/66A GB5567166A GB1178400A GB 1178400 A GB1178400 A GB 1178400A GB 55671/66 A GB55671/66 A GB 55671/66A GB 5567166 A GB5567166 A GB 5567166A GB 1178400 A GB1178400 A GB 1178400A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkylation
- prepared
- nitriles
- cooh
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001412 amines Chemical class 0.000 title abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- 230000029936 alkylation Effects 0.000 abstract 4
- 238000005804 alkylation reaction Methods 0.000 abstract 4
- 150000007513 acids Chemical class 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000002825 nitriles Chemical class 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- -1 nitro, hydroxy Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- ZGFPIGGZMWGPPW-UHFFFAOYSA-N formaldehyde;formic acid Chemical compound O=C.OC=O ZGFPIGGZMWGPPW-UHFFFAOYSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB55671/66A GB1178400A (en) | 1966-12-13 | 1966-12-13 | Nitrogen Substituted Amines and their process of Preparation. |
| BE706828D BE706828A (enExample) | 1966-12-13 | 1967-11-21 | |
| CH1642267A CH492681A (fr) | 1966-12-13 | 1967-11-23 | Procédé de préparation d'amides substitués sur l'azote |
| US686722A US3639476A (en) | 1966-12-13 | 1967-11-29 | Substituted 1-dimethylamino pentanes and heptanes |
| ES348061A ES348061A1 (es) | 1966-12-13 | 1967-12-07 | Procedimiento de preparacion de nuevas amidas sustituidas en el nitrogeno y sus amidas correspondientes. |
| DE19671643907 DE1643907A1 (de) | 1966-12-13 | 1967-12-08 | Neue,am Stickstoff substituierte Amide,die entsprechenden Amine und Verfahren zu ihrer Herstellung |
| FR1553148D FR1553148A (enExample) | 1966-12-13 | 1967-12-11 | |
| NL6716851A NL6716851A (enExample) | 1966-12-13 | 1967-12-12 | |
| FR131845A FR8020M (enExample) | 1966-12-13 | 1967-12-12 | |
| FR183311A FR8291M (enExample) | 1966-12-13 | 1969-04-08 | |
| CA087436A CA920591A (en) | 1966-12-13 | 1970-07-06 | Amides substitues sur l'azote et procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB55671/66A GB1178400A (en) | 1966-12-13 | 1966-12-13 | Nitrogen Substituted Amines and their process of Preparation. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1178400A true GB1178400A (en) | 1970-01-21 |
Family
ID=10474546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55671/66A Expired GB1178400A (en) | 1966-12-13 | 1966-12-13 | Nitrogen Substituted Amines and their process of Preparation. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3639476A (enExample) |
| BE (1) | BE706828A (enExample) |
| CH (1) | CH492681A (enExample) |
| DE (1) | DE1643907A1 (enExample) |
| ES (1) | ES348061A1 (enExample) |
| FR (3) | FR1553148A (enExample) |
| GB (1) | GB1178400A (enExample) |
| NL (1) | NL6716851A (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164415A (en) * | 1976-04-02 | 1979-08-14 | American Cyanamid Co. | Branched alkyl-2-naphthaleneacetic acids as herbicides and insecticide intermediates |
| EP0005848A1 (de) * | 1978-06-05 | 1979-12-12 | Ciba-Geigy Ag | N-Alkylierte Aminoalkohole und ihre Salze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
| US5391819A (en) * | 1992-09-30 | 1995-02-21 | Merck & Co., Inc. | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists |
| US7094790B2 (en) | 2003-05-07 | 2006-08-22 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
| US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2035785A6 (enExample) * | 1969-03-28 | 1970-12-24 | Delalande Sa | |
| FR2068439A6 (en) * | 1969-11-21 | 1971-08-27 | Delalande Sa | 2-ethoxy-5-chlorophenylalkyl dimethylamines diuretics |
| BE790074A (fr) * | 1971-10-21 | 1973-02-01 | Blaise Rolland | Nouveaux composes derives de la tetrahydroisoquinoleine et la gamma-benzopyrone et leurs procedes de preparation |
| GB1473262A (en) * | 1974-11-20 | 1977-05-11 | Delalande Sa | Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application |
| US4162327A (en) * | 1975-12-29 | 1979-07-24 | Chinoin Gyogysler Es Vegyeszeti Termeken Gyara Rt. | N,N-Disubstituted-2-furylethyl amines |
| GB1540463A (en) * | 1976-10-07 | 1979-02-14 | Ici Ltd | Alkanolamine derivatives |
| US4277501A (en) * | 1977-12-19 | 1981-07-07 | Eli Lilly And Company | Para-nitrophenylalkylamines and pharmaceutical compositions |
| DE2830127A1 (de) * | 1978-07-08 | 1980-01-17 | Basf Ag | N-arylpropyl-substituierte cyclische amine |
| ZW9580A1 (en) * | 1979-05-21 | 1981-12-23 | Ici Ltd | 1-phenyl-2-aminoethanol derivatives |
| US4336269A (en) * | 1979-12-10 | 1982-06-22 | Eli Lilly And Company | Para-nitrophenylalkylamines |
| US4288621A (en) * | 1979-12-10 | 1981-09-08 | Zoecon Corporation | Substituted 2,2-dimethylcyclopropaneamides |
| FR2530236B1 (fr) * | 1982-07-16 | 1985-08-02 | Delalande Sa | Nouveaux derives aminoalkyl naphtaleniques, leurs sels d'addition d'acide et le procede de preparation ainsi que l'application en therapeutique de ces derives et sels |
| US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
| US5097035A (en) * | 1984-07-09 | 1992-03-17 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
| US4810703A (en) * | 1984-10-19 | 1989-03-07 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-alpha, alpha-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4812451A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha. |
| US4812452A (en) * | 1984-10-19 | 1989-03-14 | A. H. Robins Company, Incorporated | 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4594343A (en) * | 1984-10-19 | 1986-06-10 | Shanklin Jr James R | 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles |
| US4876282A (en) * | 1987-11-25 | 1989-10-24 | Eli Lilly And Company | 1-Phenylalkylamines as selective serotonin uptake inhibitors |
| AU634871B2 (en) * | 1990-03-20 | 1993-03-04 | Banyu Pharmaceutical Co., Ltd. | Substituted amine derivatives having anti-hyperlipemia activity |
| US5338739A (en) * | 1994-03-10 | 1994-08-16 | Hoechst-Roussel Pharmaceuticals Inc. | (Pyrrolidinyl)phenyl carbamates, compositions and use |
| US20050256309A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands |
| US20050256118A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
-
1966
- 1966-12-13 GB GB55671/66A patent/GB1178400A/en not_active Expired
-
1967
- 1967-11-21 BE BE706828D patent/BE706828A/xx unknown
- 1967-11-23 CH CH1642267A patent/CH492681A/fr not_active IP Right Cessation
- 1967-11-29 US US686722A patent/US3639476A/en not_active Expired - Lifetime
- 1967-12-07 ES ES348061A patent/ES348061A1/es not_active Expired
- 1967-12-08 DE DE19671643907 patent/DE1643907A1/de active Pending
- 1967-12-11 FR FR1553148D patent/FR1553148A/fr not_active Expired
- 1967-12-12 FR FR131845A patent/FR8020M/fr not_active Expired
- 1967-12-12 NL NL6716851A patent/NL6716851A/xx unknown
-
1969
- 1969-04-08 FR FR183311A patent/FR8291M/fr not_active Expired
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164415A (en) * | 1976-04-02 | 1979-08-14 | American Cyanamid Co. | Branched alkyl-2-naphthaleneacetic acids as herbicides and insecticide intermediates |
| EP0005848A1 (de) * | 1978-06-05 | 1979-12-12 | Ciba-Geigy Ag | N-Alkylierte Aminoalkohole und ihre Salze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
| US5391819A (en) * | 1992-09-30 | 1995-02-21 | Merck & Co., Inc. | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists |
| US7456196B2 (en) | 2002-11-12 | 2008-11-25 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7947711B2 (en) | 2002-11-12 | 2011-05-24 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US8273767B2 (en) | 2002-11-12 | 2012-09-25 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
| US7358263B2 (en) | 2003-05-07 | 2008-04-15 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| US7094790B2 (en) | 2003-05-07 | 2006-08-22 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| US7807697B2 (en) | 2003-05-07 | 2010-10-05 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| US8106088B2 (en) | 2003-05-07 | 2012-01-31 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
| US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
Also Published As
| Publication number | Publication date |
|---|---|
| FR8291M (enExample) | 1970-11-09 |
| CH492681A (fr) | 1970-06-30 |
| ES348061A1 (es) | 1969-03-01 |
| FR8020M (enExample) | 1970-08-03 |
| FR1553148A (enExample) | 1969-01-10 |
| US3639476A (en) | 1972-02-01 |
| NL6716851A (enExample) | 1968-06-14 |
| DE1643907A1 (de) | 1970-09-24 |
| BE706828A (enExample) | 1968-05-21 |
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