GB1175808A - Improvements in or relating to new Therapeutic Composition, new Coumarin Derivatives and their process of preparation - Google Patents
Improvements in or relating to new Therapeutic Composition, new Coumarin Derivatives and their process of preparationInfo
- Publication number
- GB1175808A GB1175808A GB02757/68A GB1275768A GB1175808A GB 1175808 A GB1175808 A GB 1175808A GB 02757/68 A GB02757/68 A GB 02757/68A GB 1275768 A GB1275768 A GB 1275768A GB 1175808 A GB1175808 A GB 1175808A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- new
- compounds
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,175,808. Coumarin derivatives. LABORATOIRES LA ROCHE NAVARRON. 15 March, 1968 [24 Nov., 1967], No. 12757/68. Heading C2C. Compounds of the formula wherein R 1 and R 2 may be the same or different and each represent a hydrogen atom, an alkyl radical of 1-5 carbon atoms, or an alkoxy radical of 1-5 carbon atoms, and R is phenyl or α-naphthyl radical, or a phenyl or α-naphthyl radical substituted with at least one alkoxy group having 1-5 carbon atoms, and when R is an unsubstituted phenyl or α-naphthyl radical then one at least of the groups R 1 and R 2 is other than hydrogen, are prepared by reacting a substituted ethyl malonate of the formula with a substituted phenol of the formula wherein R, R 1 and R 2 being as already defined. The invention also comprises the compounds of the above formula (with the exception of already known 4-hydroxy-3-(ortho-methoxyphenyl)-coumarin) wherein R, R 1 and R 2 are as already defined, with the additional exception that one at least of the groups R 1 and R 2 should be other than hydrogen when R is an orthomethoxyphenyl radical. Pharmaceutical compositions containing the compounds of Formula I are administered orally associated with the usual vehicle and excipient as anticoagulants in carbiovascular conditions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR129489A FR6928M (en) | 1967-11-24 | 1967-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1175808A true GB1175808A (en) | 1969-12-23 |
Family
ID=8642199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB02757/68A Expired GB1175808A (en) | 1967-11-24 | 1968-03-15 | Improvements in or relating to new Therapeutic Composition, new Coumarin Derivatives and their process of preparation |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE710483A (en) |
| FR (1) | FR6928M (en) |
| GB (1) | GB1175808A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0553590A1 (en) * | 1992-01-31 | 1993-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Antithrombotics derived from coumarin and process for obtaining them. |
| WO1996031206A2 (en) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
| WO2007016525A2 (en) * | 2005-07-29 | 2007-02-08 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| US7846915B2 (en) | 2004-10-20 | 2010-12-07 | Resverlogix Corporation | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| US8114995B2 (en) | 2008-06-26 | 2012-02-14 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
| US8952021B2 (en) | 2009-01-08 | 2015-02-10 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9238640B2 (en) | 2009-03-18 | 2016-01-19 | Resverlogix Corp. | Anti-inflammatory agents |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| US9610251B2 (en) | 2011-11-01 | 2017-04-04 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
-
1967
- 1967-11-24 FR FR129489A patent/FR6928M/fr not_active Expired
-
1968
- 1968-02-07 BE BE710483D patent/BE710483A/xx unknown
- 1968-03-15 GB GB02757/68A patent/GB1175808A/en not_active Expired
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0553590A1 (en) * | 1992-01-31 | 1993-08-04 | Laboratorios Farmaceuticos Rovi, S.A. | Antithrombotics derived from coumarin and process for obtaining them. |
| WO1996031206A2 (en) * | 1995-04-07 | 1996-10-10 | Warner-Lambert Company | Flavones and coumarins as agents for the treatment of atherosclerosis |
| WO1996031206A3 (en) * | 1995-04-07 | 1996-12-12 | Warner Lambert Co | Flavones and coumarins as agents for the treatment of atherosclerosis |
| US8093273B2 (en) | 2004-10-20 | 2012-01-10 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| US8242130B2 (en) | 2004-10-20 | 2012-08-14 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
| US7846915B2 (en) | 2004-10-20 | 2010-12-07 | Resverlogix Corporation | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases |
| US8410109B2 (en) | 2005-07-29 | 2013-04-02 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| CN101365446B (en) * | 2005-07-29 | 2013-05-22 | 雷斯弗洛吉克斯公司 | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| WO2007016525A2 (en) * | 2005-07-29 | 2007-02-08 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| WO2007016525A3 (en) * | 2005-07-29 | 2007-05-31 | Resverlogix Corp | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| US9199990B2 (en) | 2007-02-01 | 2015-12-01 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| US8889698B2 (en) | 2007-02-01 | 2014-11-18 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
| US10532054B2 (en) | 2007-02-01 | 2020-01-14 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| US8114995B2 (en) | 2008-06-26 | 2012-02-14 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
| US8952021B2 (en) | 2009-01-08 | 2015-02-10 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| US10131640B2 (en) | 2009-03-18 | 2018-11-20 | Resverlogix Corp. | Anti-inflammatory agents |
| US9238640B2 (en) | 2009-03-18 | 2016-01-19 | Resverlogix Corp. | Anti-inflammatory agents |
| US11407719B2 (en) | 2009-03-18 | 2022-08-09 | Resverlogix Corp. | Anti-inflammatory agents |
| US10882828B2 (en) | 2009-03-18 | 2021-01-05 | Resverlogix Corp. | Anti-inflammatory agents |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| US9610251B2 (en) | 2011-11-01 | 2017-04-04 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US10016426B2 (en) | 2011-11-01 | 2018-07-10 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9278940B2 (en) | 2012-11-21 | 2016-03-08 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
| US10772894B2 (en) | 2015-03-13 | 2020-09-15 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| FR6928M (en) | 1969-05-05 |
| BE710483A (en) | 1968-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1175808A (en) | Improvements in or relating to new Therapeutic Composition, new Coumarin Derivatives and their process of preparation | |
| ATE910T1 (en) | DERIVATIVES OF 3.5-DIHYDROXYPENTANOIC ACID ESTER WITH ANTIHYPERLIPEMIC ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| GB1392275A (en) | Therapeutic compositions | |
| GB1228096A (en) | ||
| ES480809A1 (en) | Imidazole derivatives, process for their preparation and pharmaceutical compositions containing them. | |
| GB1252088A (en) | ||
| IE32453B1 (en) | Pteridine derivatives | |
| GB1229082A (en) | ||
| GB1491825A (en) | Hindered hydroxyphenylalkanoates of substituted isopropanols and stabilized compositions | |
| GB1212174A (en) | Process for the production of new 2-oxo-1,2-dihydroquinoline derivatives | |
| GB1274809A (en) | Evomonoside derivatives | |
| GB1472279A (en) | 2-azacycloalkylmethyl ketones and corresponding alcohols | |
| GB1396493A (en) | Purifying alkyl vinyl ethers | |
| GB1272340A (en) | Derivatives of neriifolin | |
| GB1237658A (en) | Substituted 1-oxy-1-thiono-3-halogen- or -3-alkyl phospholines | |
| GB1512179A (en) | Thionobenzenephosphonic acid 0,0-diesters and their use as insecticides and acaricides | |
| GB1158473A (en) | Derivatives of Benzothiopyrone and process for preparing them | |
| GB898590A (en) | New octahydroindole derivatives | |
| RU1831483C (en) | Method of preparing macarlide compounds | |
| GB1207864A (en) | Substituted triazolyl coumarin compounds | |
| GB1389822A (en) | Substituted benzopyrans and processes for their preparation | |
| GB1309122A (en) | Process for the manufacture of phosphoric acid esters and phosphonic acid esters | |
| GB1217689A (en) | Ethyl esters of fluro-acetic acids | |
| GB1367539A (en) | Coumarin sun-screening compounds and compositions containing them | |
| JPS5622741A (en) | Preparation of colorless o-phenylphenol |