GB1171619A - Vaccine adjuvants - Google Patents

Vaccine adjuvants

Info

Publication number
GB1171619A
GB1171619A GB1332266A GB1332266A GB1171619A GB 1171619 A GB1171619 A GB 1171619A GB 1332266 A GB1332266 A GB 1332266A GB 1332266 A GB1332266 A GB 1332266A GB 1171619 A GB1171619 A GB 1171619A
Authority
GB
United Kingdom
Prior art keywords
sulphonate
phenoxyethyl
nhr
march
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1332266A
Inventor
Harold Francis Hodson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB44453/61A external-priority patent/GB1003889A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB1332266A priority Critical patent/GB1171619A/en
Priority to CH404967A priority patent/CH544742A/en
Priority to FR100002A priority patent/FR92830E/en
Priority to BE696102D priority patent/BE696102A/xx
Priority to CA986208A priority patent/CA921049A/en
Priority to FR111445A priority patent/FR6597M/fr
Publication of GB1171619A publication Critical patent/GB1171619A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1,171,619. Vaccines. WELLCOME FOUNDATION Ltd. 16 March, 1967 [25 March, 1966], No. 13322/66. Addition to 1,003,889. Heading A5B. [Also in Division C2] A vaccine comprises a non-pathogenic antigenic material (e.g. diptheria formol toxoid) and a novel adjuvant comprising an acid addition salt containing a cation of the formula: [CH 3 (CH 2 ) m -A-(CH 2 ) n -X-C(NHR<SP>2</SP>)NHR<SP>1</SP>]<SP>+</SP> or a corresponding free base, wherein R<SP>1</SP> is C 1-4 alkyl, R<SP>2</SP> is C 1-4 alkyl or 2-phenoxyethyl, X is S or NH, A is CH 2 or O, n is 2 or 3 and m is 11-15, provided that when A is CH 2 and X is NH, then R<SP>2</SP> is 2-phenoxyethyl. The anion in the acid addition salts may be Br- Cl-, I-, SO 4 2-, toluene-p-sulphonate, p-chlorobenzene-sulphonate, naphthalene-2-sulphonate, maleate or tatrate. An immunising set comprises preparations containing a non-pathogenic antigenic material and an adjuvant as defined above, which may be packed separately, to be used in combined form as a vaccine containing both.
GB1332266A 1961-12-12 1966-03-25 Vaccine adjuvants Expired GB1171619A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1332266A GB1171619A (en) 1961-12-12 1966-03-25 Vaccine adjuvants
CH404967A CH544742A (en) 1961-12-12 1967-03-21 Guanidines and isothioureas adjuvants for diptheria and
FR100002A FR92830E (en) 1961-12-12 1967-03-23 Preparation of new guanidines, iso-ureas and iso-thioureas endowed in particular with a biological activity.
BE696102D BE696102A (en) 1961-12-12 1967-03-24
CA986208A CA921049A (en) 1966-03-25 1967-03-25 Guanidines and thioureas
FR111445A FR6597M (en) 1961-12-12 1967-06-22

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB44453/61A GB1003889A (en) 1961-12-12 1961-12-12 Guanidines and isothioureas
GB1332266A GB1171619A (en) 1961-12-12 1966-03-25 Vaccine adjuvants

Publications (1)

Publication Number Publication Date
GB1171619A true GB1171619A (en) 1969-11-26

Family

ID=26249709

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1332266A Expired GB1171619A (en) 1961-12-12 1966-03-25 Vaccine adjuvants

Country Status (4)

Country Link
BE (1) BE696102A (en)
CH (1) CH544742A (en)
FR (2) FR92830E (en)
GB (1) GB1171619A (en)

Also Published As

Publication number Publication date
FR92830E (en) 1969-01-03
CH544742A (en) 1974-01-15
BE696102A (en) 1967-09-25
FR6597M (en) 1969-01-06

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