GB1158723A - Amino Acid Derivatives - Google Patents

Amino Acid Derivatives

Info

Publication number
GB1158723A
GB1158723A GB8526/69A GB852669A GB1158723A GB 1158723 A GB1158723 A GB 1158723A GB 8526/69 A GB8526/69 A GB 8526/69A GB 852669 A GB852669 A GB 852669A GB 1158723 A GB1158723 A GB 1158723A
Authority
GB
United Kingdom
Prior art keywords
carboxy
aspartic acid
solvent
reacting
anhydrides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8526/69A
Other languages
English (en)
Inventor
Erwin Frederick Schoenewaldt
Robert Gibb Strachan
Daniel Frank Veber
Harvey Schwam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1158723A publication Critical patent/GB1158723A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/086—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Arc Welding In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB8526/69A 1965-07-02 1966-06-22 Amino Acid Derivatives Expired GB1158723A (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US46931065A 1965-07-02 1965-07-02
US50497865A 1965-10-24 1965-10-24
US50498265A 1965-10-24 1965-10-24
US53854266A 1966-03-30 1966-03-30
US53856066A 1966-03-30 1966-03-30
US54438066A 1966-04-22 1966-04-22
US54435866A 1966-04-22 1966-04-22
US54585566A 1966-04-28 1966-04-28
US54586266A 1966-04-28 1966-04-28
US54585766A 1966-04-28 1966-04-28
GB27965/66A GB1158721A (en) 1965-07-02 1966-06-22 Peptide synthesis

Publications (1)

Publication Number Publication Date
GB1158723A true GB1158723A (en) 1969-07-16

Family

ID=27581645

Family Applications (7)

Application Number Title Priority Date Filing Date
GB9280/69A Expired GB1158726A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB8527/69A Expired GB1158724A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB8526/69A Expired GB1158723A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB27965/66A Expired GB1158721A (en) 1965-07-02 1966-06-22 Peptide synthesis
GB9281/69A Expired GB1158727A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB49475/67A Expired GB1158722A (en) 1965-07-02 1966-06-22 N-Thiocarboxyamino Acid Anhydrides
GB9279/69A Expired GB1158725A (en) 1965-07-02 1966-06-22 Production of N-Carboxy Anhydrides of Amino Acids

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB9280/69A Expired GB1158726A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB8527/69A Expired GB1158724A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives

Family Applications After (4)

Application Number Title Priority Date Filing Date
GB27965/66A Expired GB1158721A (en) 1965-07-02 1966-06-22 Peptide synthesis
GB9281/69A Expired GB1158727A (en) 1965-07-02 1966-06-22 Amino Acid Derivatives
GB49475/67A Expired GB1158722A (en) 1965-07-02 1966-06-22 N-Thiocarboxyamino Acid Anhydrides
GB9279/69A Expired GB1158725A (en) 1965-07-02 1966-06-22 Production of N-Carboxy Anhydrides of Amino Acids

Country Status (13)

Country Link
US (3) US3435046A (enExample)
JP (1) JPS4737921B1 (enExample)
AT (4) AT289105B (enExample)
BR (1) BR6680930D0 (enExample)
CH (1) CH495956A (enExample)
DE (8) DE1795523A1 (enExample)
DK (1) DK138369B (enExample)
FI (1) FI48184C (enExample)
GB (7) GB1158726A (enExample)
IL (6) IL34876A (enExample)
NO (1) NO128326B (enExample)
SE (4) SE349038B (enExample)
YU (1) YU31197B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716151A (en) * 1984-08-16 1987-12-29 Rhone-Poulenc Sante Tripeptides and their use

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1675379B1 (de) * 1968-01-13 1972-03-09 Roesinger Heinz Rollringdichtung fuer muffenrohr verbindungen
NL7002228A (enExample) * 1970-02-18 1971-08-20
DE3542784A1 (de) * 1985-12-04 1987-06-11 Hella Kg Hueck & Co Scheinwerfer fuer kraftfahrzeuge
JPH0383990A (ja) * 1989-08-28 1991-04-09 Nippon Paint Co Ltd オキサゾリジン化合物
IN184759B (enExample) * 1997-07-22 2000-09-23 Kaneka Corp
KR20010023450A (ko) * 1998-07-21 2001-03-26 후루타 다케시 엔-(1(에스)-에톡시카르보닐-3-페닐프로필)-엘-아라닐-엘-프롤린의 말레인산염의 정출방법
DE19936976A1 (de) 1999-08-05 2001-02-08 Emil Siegwart Flanschverbindung von Rohren, insbesondere Luftleitungsrohren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993053A (en) * 1961-07-18 Production of n-carboxy-a-amino
US2716647A (en) * 1952-07-30 1955-08-30 Monsanto Chemicals N-carboxy anhydride of alpha-amino acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716151A (en) * 1984-08-16 1987-12-29 Rhone-Poulenc Sante Tripeptides and their use

Also Published As

Publication number Publication date
GB1158724A (en) 1969-07-16
DE1795524A1 (de) 1972-01-13
DE1795522A1 (de) 1972-01-13
US3459760A (en) 1969-08-05
IL34879A (en) 1971-03-24
DE1795528A1 (de) 1972-01-13
SE349038B (enExample) 1972-09-18
AT297677B (de) 1972-04-10
GB1158721A (en) 1969-07-16
US3467667A (en) 1969-09-16
DK138369B (da) 1978-08-21
DK138369C (enExample) 1979-02-05
IL34877A (en) 1971-03-24
CH495956A (de) 1970-09-15
DE1795521A1 (de) 1972-01-13
NO128326B (enExample) 1973-10-29
SE345998B (enExample) 1972-06-19
GB1158725A (en) 1969-07-16
IL34878A (en) 1971-02-25
GB1158726A (en) 1969-07-16
DE1795519A1 (de) 1972-01-13
AT289105B (de) 1971-04-13
DE1793597A1 (de) 1972-03-16
SE347512B (enExample) 1972-08-07
FI48184C (fi) 1974-07-10
GB1158722A (en) 1969-07-16
IL34876A (en) 1971-02-25
IL25974A (en) 1971-02-25
BR6680930D0 (pt) 1973-11-13
IL34880A (en) 1970-11-30
JPS4737921B1 (enExample) 1972-09-25
AT290490B (de) 1971-06-11
AT307630B (de) 1973-05-25
DE1795523A1 (de) 1972-01-13
YU31197B (en) 1973-02-28
GB1158727A (en) 1969-07-16
FI48184B (enExample) 1974-04-01
DE1795529A1 (de) 1972-01-13
US3435046A (en) 1969-03-25
SE364716B (enExample) 1974-03-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee