GB1156719A - Improvements in or relating to the production of Substituted Amines - Google Patents

Improvements in or relating to the production of Substituted Amines

Info

Publication number
GB1156719A
GB1156719A GB55188/66A GB5518866A GB1156719A GB 1156719 A GB1156719 A GB 1156719A GB 55188/66 A GB55188/66 A GB 55188/66A GB 5518866 A GB5518866 A GB 5518866A GB 1156719 A GB1156719 A GB 1156719A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydroxypropyltheophylline
theophylline
formula
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB55188/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerot Pharmazeutika GmbH
Original Assignee
Gerot Pharmazeutika GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT1111865A external-priority patent/AT269171B/en
Priority claimed from AT272766A external-priority patent/AT270673B/en
Application filed by Gerot Pharmazeutika GmbH filed Critical Gerot Pharmazeutika GmbH
Publication of GB1156719A publication Critical patent/GB1156719A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,156,719. Purine derivatives. W. OTTO, and L. SAILER, [trading as GEROT-PHARMAZEUTIKA DR. WALTER OTTO K.G.]. 9 Dec., 1966 [10 Dec., 1965; 22 March, 1966], No. 55188/66. Heading C2C. Compounds of general Formula I wherein R 1 is H or alkyl; R 2 is H or OH; R 3 and R 4 are H if R 1 is alkyl and R 2 = OH, or are each halogen, alkyl or OH possibly etherified; A is Th.CH.CH 2 - or ThCH 2 .CH(R 5 ).CH 2 -, wherein Th is a theobromine or theophylline residue and R 5 is H or, if one of R 1 to R 4 is not H, OH, and Z is A or may be alkyl or H when A is Th.CH 2 .CH(OH).CH 2 -, are prepared by reacting a compound of formula wherein R 6 is H or alkyl either with a compound of formula A-halogen or firstly with epichlorohydrin and then with theobromine and/or theophylline. The following compounds are claimed as novel:-Norephedrin - N - hydroxypropyltheophylline, norephedrin - N - di(hydroxypropyltheophylline), ephedrin - N - hydroxypropyltheophylline and N-[2-hydroxy-3-(theophylline - 7) - propyl] - 2 - hydroxy - 2 - (3<SP>1</SP> - hydroxyphenyl)-ethylamine HCl.
GB55188/66A 1965-12-10 1966-12-09 Improvements in or relating to the production of Substituted Amines Expired GB1156719A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT1111865A AT269171B (en) 1965-12-10 1965-12-10 Process for the preparation of new substituted amines and their salts
AT272766A AT270673B (en) 1966-03-22 1966-03-22 Process for the preparation of new substituted amines or their salts

Publications (1)

Publication Number Publication Date
GB1156719A true GB1156719A (en) 1969-07-02

Family

ID=25598985

Family Applications (1)

Application Number Title Priority Date Filing Date
GB55188/66A Expired GB1156719A (en) 1965-12-10 1966-12-09 Improvements in or relating to the production of Substituted Amines

Country Status (8)

Country Link
JP (1) JPS5113160B1 (en)
BE (1) BE690863A (en)
CH (2) CH496013A (en)
DE (1) DE1695100A1 (en)
ES (1) ES334064A1 (en)
FR (2) FR1504939A (en)
GB (1) GB1156719A (en)
SE (1) SE345669B (en)

Also Published As

Publication number Publication date
ES334064A1 (en) 1967-10-16
DE1695100A1 (en) 1970-12-10
FR1504939A (en) 1967-12-08
CH496014A (en) 1970-09-15
JPS5113160B1 (en) 1976-04-26
SE345669B (en) 1972-06-05
FR7018M (en) 1969-06-09
CH496013A (en) 1970-09-15
BE690863A (en) 1967-06-08

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees