GB1156498A - Novel 2,6-Dimethyl-4-Phenyl-Piperazines and process for the manufacture thereof - Google Patents
Novel 2,6-Dimethyl-4-Phenyl-Piperazines and process for the manufacture thereofInfo
- Publication number
- GB1156498A GB1156498A GB35441/65A GB3544165A GB1156498A GB 1156498 A GB1156498 A GB 1156498A GB 35441/65 A GB35441/65 A GB 35441/65A GB 3544165 A GB3544165 A GB 3544165A GB 1156498 A GB1156498 A GB 1156498A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- give
- piperazines
- dimethyl
- piperazinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RADPVVIPUAGLPO-UHFFFAOYSA-N 3,5-dimethyl-1-phenylpiperazine Chemical class C1C(C)NC(C)CN1C1=CC=CC=C1 RADPVVIPUAGLPO-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 abstract 2
- 150000004885 piperazines Chemical class 0.000 abstract 2
- HXLYWANQJMKLNP-UHFFFAOYSA-N 1-n'-phenylpropane-1,1-diamine Chemical compound CCC(N)NC1=CC=CC=C1 HXLYWANQJMKLNP-UHFFFAOYSA-N 0.000 abstract 1
- MONMFXREYOKQTI-UHFFFAOYSA-N 2-bromopropanoic acid Chemical compound CC(Br)C(O)=O MONMFXREYOKQTI-UHFFFAOYSA-N 0.000 abstract 1
- OZGMODDEIHYPRY-UHFFFAOYSA-N 2-bromopropanoyl chloride Chemical compound CC(Br)C(Cl)=O OZGMODDEIHYPRY-UHFFFAOYSA-N 0.000 abstract 1
- BCJSNPDGPKGZHD-UHFFFAOYSA-N 3,5-dimethyl-1-phenylpiperazin-2-one Chemical compound O=C1C(C)NC(C)CN1C1=CC=CC=C1 BCJSNPDGPKGZHD-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000003931 anilides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- ARFLASKVLJTEJD-UHFFFAOYSA-N ethyl 2-bromopropanoate Chemical compound CCOC(=O)C(C)Br ARFLASKVLJTEJD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/023—Preparation; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL132355D NL132355C (enrdf_load_html_response) | 1965-08-18 | ||
| GB35441/65A GB1156498A (en) | 1965-08-18 | 1965-08-18 | Novel 2,6-Dimethyl-4-Phenyl-Piperazines and process for the manufacture thereof |
| CH1043966A CH462823A (de) | 1965-08-18 | 1966-07-19 | Verfahren zur Herstellung von pharmakologisch wirksamen Verbindungen |
| DE19661595903 DE1595903B1 (de) | 1965-08-18 | 1966-07-23 | 1-Substituierte 2,6-Dimethyl-4-phenylpiperazine |
| BR18192366A BR6681923D0 (pt) | 1965-08-18 | 1966-08-05 | Piperazina |
| NL6611479A NL6611479A (enrdf_load_html_response) | 1965-08-18 | 1966-08-16 | |
| FR1568736D FR1568736A (enrdf_load_html_response) | 1965-08-18 | 1966-08-17 | |
| FR84018A FR6128M (enrdf_load_html_response) | 1965-08-18 | 1966-11-17 | |
| NL707011861A NL139171B (nl) | 1965-08-18 | 1970-08-11 | Werkwijze voor het bereiden van een 2,6-dimethylpiperazineverbinding. |
| NL727211073A NL145239B (nl) | 1965-08-18 | 1972-08-14 | Werkwijze voor het bereiden van een 2,6-dimethylpiperazineverbinding. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB35441/65A GB1156498A (en) | 1965-08-18 | 1965-08-18 | Novel 2,6-Dimethyl-4-Phenyl-Piperazines and process for the manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1156498A true GB1156498A (en) | 1969-06-25 |
Family
ID=10377767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35441/65A Expired GB1156498A (en) | 1965-08-18 | 1965-08-18 | Novel 2,6-Dimethyl-4-Phenyl-Piperazines and process for the manufacture thereof |
Country Status (6)
| Country | Link |
|---|---|
| BR (1) | BR6681923D0 (enrdf_load_html_response) |
| CH (1) | CH462823A (enrdf_load_html_response) |
| DE (1) | DE1595903B1 (enrdf_load_html_response) |
| FR (2) | FR1568736A (enrdf_load_html_response) |
| GB (1) | GB1156498A (enrdf_load_html_response) |
| NL (2) | NL6611479A (enrdf_load_html_response) |
-
0
- NL NL132355D patent/NL132355C/xx active
-
1965
- 1965-08-18 GB GB35441/65A patent/GB1156498A/en not_active Expired
-
1966
- 1966-07-19 CH CH1043966A patent/CH462823A/de unknown
- 1966-07-23 DE DE19661595903 patent/DE1595903B1/de active Pending
- 1966-08-05 BR BR18192366A patent/BR6681923D0/pt unknown
- 1966-08-16 NL NL6611479A patent/NL6611479A/xx unknown
- 1966-08-17 FR FR1568736D patent/FR1568736A/fr not_active Expired
- 1966-11-17 FR FR84018A patent/FR6128M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1595903B1 (de) | 1972-03-09 |
| NL6611479A (enrdf_load_html_response) | 1967-02-20 |
| FR1568736A (enrdf_load_html_response) | 1969-05-30 |
| NL132355C (enrdf_load_html_response) | |
| FR6128M (enrdf_load_html_response) | 1968-06-24 |
| BR6681923D0 (pt) | 1973-10-25 |
| CH462823A (de) | 1968-09-30 |
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