GB1153796A - A method of Preparing Substituted Benzamides - Google Patents
A method of Preparing Substituted BenzamidesInfo
- Publication number
- GB1153796A GB1153796A GB50701/66A GB5070166A GB1153796A GB 1153796 A GB1153796 A GB 1153796A GB 50701/66 A GB50701/66 A GB 50701/66A GB 5070166 A GB5070166 A GB 5070166A GB 1153796 A GB1153796 A GB 1153796A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- phenol
- nitro
- amino
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003936 benzamides Chemical class 0.000 title abstract 3
- 229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
- -1 alkenyloxy benzene Chemical compound 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
- 230000002152 alkylating effect Effects 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- 230000000802 nitrating effect Effects 0.000 abstract 2
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR43874A FR1513226A (fr) | 1965-12-27 | 1965-12-27 | Nouveau procédé de préparation de benzamides substitués |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1153796A true GB1153796A (en) | 1969-05-29 |
Family
ID=8596948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB50701/66A Expired GB1153796A (en) | 1965-12-27 | 1966-11-11 | A method of Preparing Substituted Benzamides |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS546539B1 (OSRAM) |
BE (1) | BE688790A (OSRAM) |
CH (1) | CH475949A (OSRAM) |
DE (1) | DE1543893C3 (OSRAM) |
ES (1) | ES333713A1 (OSRAM) |
FR (1) | FR1513226A (OSRAM) |
GB (1) | GB1153796A (OSRAM) |
IL (1) | IL26895A (OSRAM) |
OA (1) | OA02159A (OSRAM) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4250110A (en) | 1978-07-31 | 1981-02-10 | Asahi Kasei Kogyo Kabushiki Kaisha | Method of preparing metoclopramide |
US4279836A (en) * | 1978-05-12 | 1981-07-21 | Asahi Kasei Kogyo Kabushiki Kaisha | Hydroxamic acid derivative and method of preparing metoclopramide using same |
CN111349052A (zh) * | 2020-04-07 | 2020-06-30 | 福建海西新药创制有限公司 | 一种枸橼酸莫沙必利的合成方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2460923A1 (fr) * | 1979-07-06 | 1981-01-30 | Ile De France | Nouveau procede de preparation d'acides 2-methoxy-4-amino-5-alkylsulfonyl benzoiques |
-
1965
- 1965-12-27 FR FR43874A patent/FR1513226A/fr not_active Expired
-
1966
- 1966-10-20 OA OA52632A patent/OA02159A/xx unknown
- 1966-10-24 BE BE688790D patent/BE688790A/xx not_active IP Right Cessation
- 1966-11-11 ES ES0333713A patent/ES333713A1/es not_active Expired
- 1966-11-11 GB GB50701/66A patent/GB1153796A/en not_active Expired
- 1966-11-15 CH CH1637766A patent/CH475949A/fr not_active IP Right Cessation
- 1966-11-20 IL IL26895A patent/IL26895A/xx unknown
- 1966-12-16 DE DE1543893A patent/DE1543893C3/de not_active Expired
-
1972
- 1972-06-05 JP JP5640172A patent/JPS546539B1/ja active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4279836A (en) * | 1978-05-12 | 1981-07-21 | Asahi Kasei Kogyo Kabushiki Kaisha | Hydroxamic acid derivative and method of preparing metoclopramide using same |
US4250110A (en) | 1978-07-31 | 1981-02-10 | Asahi Kasei Kogyo Kabushiki Kaisha | Method of preparing metoclopramide |
US4297503A (en) | 1978-07-31 | 1981-10-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel benzamide derivative and method of preparing metoclopramide using same |
CN111349052A (zh) * | 2020-04-07 | 2020-06-30 | 福建海西新药创制有限公司 | 一种枸橼酸莫沙必利的合成方法 |
CN111349052B (zh) * | 2020-04-07 | 2021-02-12 | 福建海西新药创制有限公司 | 一种枸橼酸莫沙必利的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
JPS546539B1 (OSRAM) | 1979-03-29 |
FR1513226A (fr) | 1968-02-16 |
DE1543893C3 (de) | 1975-05-22 |
DE1543893A1 (de) | 1970-02-05 |
OA02159A (fr) | 1970-05-05 |
IL26895A (en) | 1971-08-25 |
CH475949A (fr) | 1969-07-31 |
BE688790A (OSRAM) | 1967-04-24 |
DE1543893B2 (de) | 1974-10-10 |
ES333713A1 (es) | 1967-10-01 |
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