GB1152697A - Improvements in or relating to Therapeutic Compositions - Google Patents

Improvements in or relating to Therapeutic Compositions

Info

Publication number
GB1152697A
GB1152697A GB2379966A GB2379966A GB1152697A GB 1152697 A GB1152697 A GB 1152697A GB 2379966 A GB2379966 A GB 2379966A GB 2379966 A GB2379966 A GB 2379966A GB 1152697 A GB1152697 A GB 1152697A
Authority
GB
United Kingdom
Prior art keywords
therapeutic compositions
tranquilizers
depressants
psychopharmacological
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2379966A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denver Chemical Manufacturing Co
Original Assignee
Denver Chemical Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denver Chemical Manufacturing Co filed Critical Denver Chemical Manufacturing Co
Publication of GB1152697A publication Critical patent/GB1152697A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam

Abstract

1,152,697. Therapeutic compositions. DENVER CHEMICAL MFG. CO. 27 May, 1966 [18 June, 1965], No. 23799/66. Heading A5B. Orally administrable therapeutic compositions comprise a mixture of a psychopharmacological drug (chosen from anti-depressants, tranquilizers and central nervous system stimulants) and an enteric coated proteolytic enzyme or hyaluronidase, but excluding any content of a pantothenyl-group-containing compound. The proteolytic enzyme may be trypsin, papain, bromelain, ficin, streptokinase, penguinan, collagenase derived from Clostridium hystolyticum, a protease derived from Bacillus subtilis, Asper gillus oryzae, Aspergillus niger or Microsporon gypseum or preferably chymotryspin. The psychopharmacological drug may be a phenothiazine derivative such as chlorpromazine, prochlorperazine, promethazine, promazine, mepazine, pyrathiazine, diethazine, perphenazine; thiopropazole, trimeprazine, trifluoperazine or trifluopromazine; a Rauwolfia alkaloid, e.g. reserpine, rescinnamine, syrosingopine or deserpidine, C.N.S. stimulants such as dextroamphetamine, methylphenidyl acetate, pipradol, azacyclonal or other tranquilizers or anti-depressants such as covatin, hydroxyzine, bentactyzine, dimethylyn, meprobamate or imipramine. The composition may be in the form of gelatin capsules or tablets comprising a core containing the enzyme coated with an enteric substance such as cellulose acetate phthalate or shellac and further comprising a compressed or sugar coating containing the psychopharmacological drug.
GB2379966A 1965-06-18 1966-05-27 Improvements in or relating to Therapeutic Compositions Expired GB1152697A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46516365A 1965-06-18 1965-06-18

Publications (1)

Publication Number Publication Date
GB1152697A true GB1152697A (en) 1969-05-21

Family

ID=23846726

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2379966A Expired GB1152697A (en) 1965-06-18 1966-05-27 Improvements in or relating to Therapeutic Compositions

Country Status (3)

Country Link
BE (1) BE682645A (en)
FR (1) FR5218M (en)
GB (1) GB1152697A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2231263A (en) * 1989-05-08 1990-11-14 Shigemi Fujisaki Use of neutral protease as activator for damaged neurocytes
RU2659200C1 (en) * 2017-07-24 2018-06-28 Общество С Ограниченной Ответственностью "Валента - Интеллект" Pharmaceutical composition containing alimamazine tartrate

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8461389B2 (en) 2008-04-18 2013-06-11 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2231263A (en) * 1989-05-08 1990-11-14 Shigemi Fujisaki Use of neutral protease as activator for damaged neurocytes
RU2659200C1 (en) * 2017-07-24 2018-06-28 Общество С Ограниченной Ответственностью "Валента - Интеллект" Pharmaceutical composition containing alimamazine tartrate

Also Published As

Publication number Publication date
BE682645A (en) 1966-12-01
FR5218M (en) 1967-07-03

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees