GB1146272A - Novel thebaine and oripavine derivatives - Google Patents
Novel thebaine and oripavine derivativesInfo
- Publication number
- GB1146272A GB1146272A GB2194/66A GB219466A GB1146272A GB 1146272 A GB1146272 A GB 1146272A GB 2194/66 A GB2194/66 A GB 2194/66A GB 219466 A GB219466 A GB 219466A GB 1146272 A GB1146272 A GB 1146272A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbons
- substituted
- group
- aryl
- dehydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZKLXUUYLEHCAMF-UUWFMWQGSA-N Oripavine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 ZKLXUUYLEHCAMF-UUWFMWQGSA-N 0.000 title abstract 3
- 229940051808 oripavine derivative analgesics Drugs 0.000 title abstract 3
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 title abstract 2
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 title abstract 2
- 229930003945 thebaine Natural products 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 4
- 125000002723 alicyclic group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- -1 nicotinoyl Chemical group 0.000 abstract 2
- VQJMAIZOEPPELO-KYGIZGOZSA-N (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-(2-hydroxy-5-methylhexan-2-yl)-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol hydrochloride Chemical compound Cl.CO[C@]12CC[C@@]3(C[C@@H]1C(C)(O)CCC(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 VQJMAIZOEPPELO-KYGIZGOZSA-N 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 abstract 1
- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2194/66A GB1146272A (en) | 1966-01-17 | 1966-01-17 | Novel thebaine and oripavine derivatives |
| NL6700612A NL6700612A (enrdf_load_stackoverflow) | 1966-01-17 | 1967-01-13 | |
| LU52808D LU52808A1 (enrdf_load_stackoverflow) | 1966-01-17 | 1967-01-13 | |
| BE692664D BE692664A (enrdf_load_stackoverflow) | 1966-01-17 | 1967-01-16 | |
| ES0335707A ES335707A1 (es) | 1966-01-17 | 1967-01-16 | Procedimiento para la preparacion de derivados de la tebaina |
| FR91484A FR1517875A (fr) | 1966-01-17 | 1967-01-17 | Procédé de préparation de dérivés de la thébaïne et de l'oripavine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2194/66A GB1146272A (en) | 1966-01-17 | 1966-01-17 | Novel thebaine and oripavine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1146272A true GB1146272A (en) | 1969-03-26 |
Family
ID=9735246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2194/66A Expired GB1146272A (en) | 1966-01-17 | 1966-01-17 | Novel thebaine and oripavine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE692664A (enrdf_load_stackoverflow) |
| ES (1) | ES335707A1 (enrdf_load_stackoverflow) |
| FR (1) | FR1517875A (enrdf_load_stackoverflow) |
| GB (1) | GB1146272A (enrdf_load_stackoverflow) |
| LU (1) | LU52808A1 (enrdf_load_stackoverflow) |
| NL (1) | NL6700612A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1164672A (en) * | 1967-03-31 | 1969-09-17 | Reckitt & Sons Ltd | Novel Derivatives of Thebaine and Oripavine, their Pharmaceutically Acceptable Salts, and to processes of their production |
| GB1164671A (en) * | 1967-03-31 | 1969-09-17 | Reckitt & Sons Ltd | Novel Derivatives of Thebaine and Oripavine to their Salts, and to processes for their preparation |
| DE2230154A1 (de) * | 1972-06-21 | 1974-01-17 | Boehringer Sohn Ingelheim | N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung |
-
1966
- 1966-01-17 GB GB2194/66A patent/GB1146272A/en not_active Expired
-
1967
- 1967-01-13 NL NL6700612A patent/NL6700612A/xx unknown
- 1967-01-13 LU LU52808D patent/LU52808A1/xx unknown
- 1967-01-16 ES ES0335707A patent/ES335707A1/es not_active Expired
- 1967-01-16 BE BE692664D patent/BE692664A/xx unknown
- 1967-01-17 FR FR91484A patent/FR1517875A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1517875A (fr) | 1968-03-22 |
| BE692664A (enrdf_load_stackoverflow) | 1967-07-03 |
| ES335707A1 (es) | 1967-12-16 |
| LU52808A1 (enrdf_load_stackoverflow) | 1967-03-13 |
| NL6700612A (enrdf_load_stackoverflow) | 1967-07-18 |
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