GB1145642A - 6-keto-í¸-steroids - Google Patents

6-keto-í¸-steroids

Info

Publication number
GB1145642A
GB1145642A GB4040166A GB4040166A GB1145642A GB 1145642 A GB1145642 A GB 1145642A GB 4040166 A GB4040166 A GB 4040166A GB 4040166 A GB4040166 A GB 4040166A GB 1145642 A GB1145642 A GB 1145642A
Authority
GB
United Kingdom
Prior art keywords
steroids
partial formula
steroid
prepared
partial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4040166A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1143065A external-priority patent/CH467760A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1145642A publication Critical patent/GB1145642A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J75/00Processes for the preparation of steroids in general
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1,145,642. 6-Keto-#<SP>7</SP>-steroids. F. HOFFMANN-LA ROCHE & CO. A.G. 9 Sept., 1966 [24 Sept., 1965; 24 March, 1966], No. 40401/66. Heading C2U. Steroids of the partial Formulµ (Ia) and (Ib) are prepared by treating a steroid of the partial Formula (II) with a base, and, when the steroid of the partial Formula (Ib) is required, reacting the steroid of the partial Formula (Ia) thus obtained with iodine and a silver salt AgOAc in an aqueous carboxylic acid AcOH (wherein R is an organic sulphonic acid acyl group and Ac is a C 1-6 aliphatic or halogenated aliphatic carboxylic acid acyl group). Steroids of the partial Formula (Ia) which contain in the 17-position one of the groups -COCH 3 , -CH(CH 3 )(CH 2 ) 3 CH(CH 3 ) 2 , -CH(CH 3 )- CH = CHCH(CH 3 )CH(CH 3 ) 2 and -CH(CH 3 ) (CH 2 ) 2 COOZ, where Z is H or -CH(CH 3 )CHO in free or functionally modified form, are novel. Steroids of the partial Formula (II ) are prepared by sulphonic acid acylation of the corresponding 3#-ols, themselves prepared by hydrolysis of their acetates.
GB4040166A 1965-08-13 1966-09-09 6-keto-í¸-steroids Expired GB1145642A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH1143065A CH467760A (en) 1965-08-13 1965-08-13 Process for the preparation of 5B-H-6-keto steroids
DESC037774 1965-09-24
CH1390765 1965-10-08
CH123166 1966-01-28
CH433666 1966-03-24

Publications (1)

Publication Number Publication Date
GB1145642A true GB1145642A (en) 1969-03-19

Family

ID=27508947

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4040166A Expired GB1145642A (en) 1965-08-13 1966-09-09 6-keto-í¸-steroids

Country Status (3)

Country Link
FI (1) FI43595B (en)
GB (1) GB1145642A (en)
IL (1) IL26452A (en)

Also Published As

Publication number Publication date
IL26452A (en) 1970-05-21
FI43595B (en) 1971-02-01

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