GB1145324A - Novel unsaturated steroidal lactone - Google Patents

Novel unsaturated steroidal lactone

Info

Publication number
GB1145324A
GB1145324A GB3961968A GB3961968A GB1145324A GB 1145324 A GB1145324 A GB 1145324A GB 3961968 A GB3961968 A GB 3961968A GB 3961968 A GB3961968 A GB 3961968A GB 1145324 A GB1145324 A GB 1145324A
Authority
GB
United Kingdom
Prior art keywords
oxa
hydroxy
converted
novel unsaturated
selective reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3961968A
Inventor
Christopher Joseph Jung
Raphael Pappo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Priority to GB3961968A priority Critical patent/GB1145324A/en
Publication of GB1145324A publication Critical patent/GB1145324A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1,145,324. A 2-oxa-steroid. G. D. SEARLE & CO. 12 April, 1966, No. 39619/68. Divided out of 1,145,322. Heading C2C. The novel 17#-hydroxy-2-oxa-estr-5(10)-en-3- one is prepared by selective reduction of the corresponding 17-keto compound which is first converted into the corresponding alkali metal or alkaline earth metal salt and in this form has the formula (wherein M is the metal) by treatment with alkali. The selective reduction may be effected with an alkali metal aluminium hydride or borohydride. The product may be converted to 17# - hydroxy - 2 - oxa - estra - 4,9(10) - dien - 3 - one by reaction with bromine in the presence of an organic base.
GB3961968A 1966-04-12 1966-04-12 Novel unsaturated steroidal lactone Expired GB1145324A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3961968A GB1145324A (en) 1966-04-12 1966-04-12 Novel unsaturated steroidal lactone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3961968A GB1145324A (en) 1966-04-12 1966-04-12 Novel unsaturated steroidal lactone

Publications (1)

Publication Number Publication Date
GB1145324A true GB1145324A (en) 1969-03-12

Family

ID=10410553

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3961968A Expired GB1145324A (en) 1966-04-12 1966-04-12 Novel unsaturated steroidal lactone

Country Status (1)

Country Link
GB (1) GB1145324A (en)

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