GB1140766A - Vaccine and its preparation - Google Patents

Vaccine and its preparation

Info

Publication number
GB1140766A
GB1140766A GB34791/66A GB3479166A GB1140766A GB 1140766 A GB1140766 A GB 1140766A GB 34791/66 A GB34791/66 A GB 34791/66A GB 3479166 A GB3479166 A GB 3479166A GB 1140766 A GB1140766 A GB 1140766A
Authority
GB
United Kingdom
Prior art keywords
vaccine
chick embryo
virus
aug
virulent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34791/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1140766A publication Critical patent/GB1140766A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165Mumps or measles virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18711Rubulavirus, e.g. mumps virus, parainfluenza 2,4
    • C12N2760/18734Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

1,140,766. Mumps vaccine. MERCK & CO. Inc. 3 Aug., 1966 [13 Aug., 1965], No. 34798/66. Heading A5B. Mumps vaccine is prepared by attenuating a live virulent mump virus by growing it in at least ten successive passages in embryonated hens eggs and then propagating it in chick embryo tissue culture containing tissue of 9-11 day old chick embryo, at 30-38‹C. Preferably at least ten chick embryo tissue passages are made. The virulent virus may be derived from clinical material, isolated in a suitable cell culture and adapted to chick embryo tissue culture. The virus containing fluids are harvested, preferably stabilised with e.g. sucrose, human albumin, glutamine, phosphate or mixtures thereof, and then stored frozen for subsequent use as a vaccine, or filled into ampules, and freeze-dried for reconstitution with sterile water to provide a vaccine.
GB34791/66A 1965-08-13 1966-08-03 Vaccine and its preparation Expired GB1140766A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47965365A 1965-08-13 1965-08-13

Publications (1)

Publication Number Publication Date
GB1140766A true GB1140766A (en) 1969-01-22

Family

ID=23904868

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34791/66A Expired GB1140766A (en) 1965-08-13 1966-08-03 Vaccine and its preparation

Country Status (14)

Country Link
JP (1) JPS5238089B1 (en)
BE (1) BE685270A (en)
BR (1) BR6681974D0 (en)
CH (1) CH475355A (en)
CS (1) CS161688B2 (en)
CY (1) CY536A (en)
DE (1) DE1617621B1 (en)
DK (1) DK116677B (en)
ES (1) ES330274A1 (en)
FI (1) FI43094B (en)
FR (2) FR5807M (en)
GB (1) GB1140766A (en)
IL (1) IL26244A (en)
NO (1) NO122031B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin

Also Published As

Publication number Publication date
CS161688B2 (en) 1975-06-10
CY536A (en) 1970-04-10
DK116677B (en) 1970-02-02
NO122031B (en) 1971-05-10
FR5807M (en) 1968-02-19
ES330274A1 (en) 1967-06-16
FI43094B (en) 1970-10-01
FR1509944A (en) 1968-01-19
BR6681974D0 (en) 1973-12-26
CH475355A (en) 1969-07-15
BE685270A (en) 1967-02-09
DE1617621B1 (en) 1971-03-04
JPS5238089B1 (en) 1977-09-27
IL26244A (en) 1970-03-22

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