GB1139506A - Steroid 17-esters - Google Patents
Steroid 17-estersInfo
- Publication number
- GB1139506A GB1139506A GB2666565A GB2666565A GB1139506A GB 1139506 A GB1139506 A GB 1139506A GB 2666565 A GB2666565 A GB 2666565A GB 2666565 A GB2666565 A GB 2666565A GB 1139506 A GB1139506 A GB 1139506A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- compound
- esters
- chlorine
- diones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Moulding By Coating Moulds (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
Abstract
1,139,506. Steroid 17-esters. GLAXO LABORATORIES Ltd. 27 May, 1966 [23 June, 1965], No. 26665/65. Heading C2U. [Also in Division A5] Novel steroids of the formula (wherein R is C 1-3 alkyl; X is chlorine or, when Y is hydroxy, bromine; and Y is chlorine or hydroxy) are prepared (1) by reacting the corresponding 9,11-unsubstituted-#<SP>9(11)</SP>-steroids with a halogenating agent supplying positive chlorine or bromine in the presence of a compound supplying Cl- or OH- ions; or (2) by converting a 9α-bromo-11#-hydroxy compound of the invention to the 9,11-epoxy compound and reacting this with aqueous hydrochloric acid to give a 9α-chloro-11#-hydroxy compound; or (3) by acylating corresponding 17α-ols. 16# - Methyl - 17α - alkanoyloxypregna - 1,4,9(11) - triene - 3,20 - diones are prepared by converting 17α,21 - dihydroxy - 16# - methylpregna - 1,4,9(11) - triene - 3,20 - diones to 17α,21-ortho-esters, hydrolysing these to the 17α- alkanoyloxy-21-ols and removing the 21-hydroxy group via the 21-mesylates.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2666565A GB1139506A (en) | 1965-06-23 | 1965-06-23 | Steroid 17-esters |
IL2590566A IL25905A (en) | 1965-06-23 | 1966-06-02 | 9alpha-halo-16beta-methyl-17alpha-acyloxy-pregna-1,4-diene-3,20-dione derivatives |
NO16339266A NO126438B (en) | 1965-06-23 | 1966-06-10 | |
SE845066A SE331473B (en) | 1965-06-23 | 1966-06-21 | |
BE682889D BE682889A (en) | 1965-06-23 | 1966-06-21 | |
ES0328249A ES328249A1 (en) | 1965-06-23 | 1966-06-22 | A procedure for the preparation of steroid compounds. (Machine-translation by Google Translate, not legally binding) |
DK321266A DK115548B (en) | 1965-06-23 | 1966-06-22 | Process for the preparation of anti-inflammatory 9α, 11β-substituted 16β-methyl-17α-propionyloxy-Δ <1,4> -pregnadiene-3,20-diones. |
FR66393A FR5824M (en) | 1965-06-23 | 1966-06-22 | |
FR66400A FR1484278A (en) | 1965-06-23 | 1966-06-22 | New steroid compounds and their preparation process |
NL6608762A NL156143B (en) | 1965-06-23 | 1966-06-23 | PROCEDURE FOR PREPARING A MEDICINAL PRODUCT WITH AN ACTION AGAINST INFLAMMATION BY A 9ALFA, 11BETA-DIGESUBSTITUATED 3,20-DIOXO-16BETA-METHYL-17ALFA-HYDROXY-PREGNADIENE-1,4-DERIVATE TE BRENCHEN DERIVATIVE THE FORMED MEDICINAL PROPERTIES OBTAINED UNDER THIS METHOD AND METHOD FOR PREPARING MEDICINAL COMPOUNDS. |
DE19661568689 DE1568689C3 (en) | 1965-06-23 | 1966-06-23 | 16 beta-methyl-pregna-1,4-diene-3,20dione derivatives, processes for their preparation and pharmaceutical compositions containing them |
CH911166A CH469691A (en) | 1965-06-23 | 1966-06-23 | Method of making steroids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2666565A GB1139506A (en) | 1965-06-23 | 1965-06-23 | Steroid 17-esters |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1139506A true GB1139506A (en) | 1969-01-08 |
Family
ID=10247245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2666565A Expired GB1139506A (en) | 1965-06-23 | 1965-06-23 | Steroid 17-esters |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE682889A (en) |
CH (1) | CH469691A (en) |
DK (1) | DK115548B (en) |
ES (1) | ES328249A1 (en) |
FR (1) | FR5824M (en) |
GB (1) | GB1139506A (en) |
IL (1) | IL25905A (en) |
NL (1) | NL156143B (en) |
NO (1) | NO126438B (en) |
SE (1) | SE331473B (en) |
-
1965
- 1965-06-23 GB GB2666565A patent/GB1139506A/en not_active Expired
-
1966
- 1966-06-02 IL IL2590566A patent/IL25905A/en unknown
- 1966-06-10 NO NO16339266A patent/NO126438B/no unknown
- 1966-06-21 BE BE682889D patent/BE682889A/xx unknown
- 1966-06-21 SE SE845066A patent/SE331473B/xx unknown
- 1966-06-22 ES ES0328249A patent/ES328249A1/en not_active Expired
- 1966-06-22 DK DK321266A patent/DK115548B/en unknown
- 1966-06-22 FR FR66393A patent/FR5824M/fr not_active Expired
- 1966-06-23 NL NL6608762A patent/NL156143B/en unknown
- 1966-06-23 CH CH911166A patent/CH469691A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL25905A (en) | 1970-08-19 |
SE331473B (en) | 1971-01-04 |
DE1568689B2 (en) | 1975-07-31 |
NL156143B (en) | 1978-03-15 |
FR5824M (en) | 1968-02-26 |
BE682889A (en) | 1966-12-21 |
NL6608762A (en) | 1966-12-27 |
DE1568689A1 (en) | 1970-06-25 |
ES328249A1 (en) | 1967-04-01 |
NO126438B (en) | 1973-02-05 |
CH469691A (en) | 1969-03-15 |
DK115548B (en) | 1969-10-20 |
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