GB1139506A - Steroid 17-esters - Google Patents

Steroid 17-esters

Info

Publication number
GB1139506A
GB1139506A GB2666565A GB2666565A GB1139506A GB 1139506 A GB1139506 A GB 1139506A GB 2666565 A GB2666565 A GB 2666565A GB 2666565 A GB2666565 A GB 2666565A GB 1139506 A GB1139506 A GB 1139506A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
compound
esters
chlorine
diones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2666565A
Inventor
Joseph Elks
Peter John May
Niall Galbraith Weir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB2666565A priority Critical patent/GB1139506A/en
Priority to IL2590566A priority patent/IL25905A/en
Priority to NO16339266A priority patent/NO126438B/no
Priority to SE845066A priority patent/SE331473B/xx
Priority to BE682889D priority patent/BE682889A/xx
Priority to ES0328249A priority patent/ES328249A1/en
Priority to DK321266A priority patent/DK115548B/en
Priority to FR66393A priority patent/FR5824M/fr
Priority to FR66400A priority patent/FR1484278A/en
Priority to NL6608762A priority patent/NL156143B/en
Priority to DE19661568689 priority patent/DE1568689C3/en
Priority to CH911166A priority patent/CH469691A/en
Publication of GB1139506A publication Critical patent/GB1139506A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Moulding By Coating Moulds (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)

Abstract

1,139,506. Steroid 17-esters. GLAXO LABORATORIES Ltd. 27 May, 1966 [23 June, 1965], No. 26665/65. Heading C2U. [Also in Division A5] Novel steroids of the formula (wherein R is C 1-3 alkyl; X is chlorine or, when Y is hydroxy, bromine; and Y is chlorine or hydroxy) are prepared (1) by reacting the corresponding 9,11-unsubstituted-#<SP>9(11)</SP>-steroids with a halogenating agent supplying positive chlorine or bromine in the presence of a compound supplying Cl- or OH- ions; or (2) by converting a 9α-bromo-11#-hydroxy compound of the invention to the 9,11-epoxy compound and reacting this with aqueous hydrochloric acid to give a 9α-chloro-11#-hydroxy compound; or (3) by acylating corresponding 17α-ols. 16# - Methyl - 17α - alkanoyloxypregna - 1,4,9(11) - triene - 3,20 - diones are prepared by converting 17α,21 - dihydroxy - 16# - methylpregna - 1,4,9(11) - triene - 3,20 - diones to 17α,21-ortho-esters, hydrolysing these to the 17α- alkanoyloxy-21-ols and removing the 21-hydroxy group via the 21-mesylates.
GB2666565A 1965-06-23 1965-06-23 Steroid 17-esters Expired GB1139506A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB2666565A GB1139506A (en) 1965-06-23 1965-06-23 Steroid 17-esters
IL2590566A IL25905A (en) 1965-06-23 1966-06-02 9alpha-halo-16beta-methyl-17alpha-acyloxy-pregna-1,4-diene-3,20-dione derivatives
NO16339266A NO126438B (en) 1965-06-23 1966-06-10
SE845066A SE331473B (en) 1965-06-23 1966-06-21
BE682889D BE682889A (en) 1965-06-23 1966-06-21
ES0328249A ES328249A1 (en) 1965-06-23 1966-06-22 A procedure for the preparation of steroid compounds. (Machine-translation by Google Translate, not legally binding)
DK321266A DK115548B (en) 1965-06-23 1966-06-22 Process for the preparation of anti-inflammatory 9α, 11β-substituted 16β-methyl-17α-propionyloxy-Δ <1,4> -pregnadiene-3,20-diones.
FR66393A FR5824M (en) 1965-06-23 1966-06-22
FR66400A FR1484278A (en) 1965-06-23 1966-06-22 New steroid compounds and their preparation process
NL6608762A NL156143B (en) 1965-06-23 1966-06-23 PROCEDURE FOR PREPARING A MEDICINAL PRODUCT WITH AN ACTION AGAINST INFLAMMATION BY A 9ALFA, 11BETA-DIGESUBSTITUATED 3,20-DIOXO-16BETA-METHYL-17ALFA-HYDROXY-PREGNADIENE-1,4-DERIVATE TE BRENCHEN DERIVATIVE THE FORMED MEDICINAL PROPERTIES OBTAINED UNDER THIS METHOD AND METHOD FOR PREPARING MEDICINAL COMPOUNDS.
DE19661568689 DE1568689C3 (en) 1965-06-23 1966-06-23 16 beta-methyl-pregna-1,4-diene-3,20dione derivatives, processes for their preparation and pharmaceutical compositions containing them
CH911166A CH469691A (en) 1965-06-23 1966-06-23 Method of making steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2666565A GB1139506A (en) 1965-06-23 1965-06-23 Steroid 17-esters

Publications (1)

Publication Number Publication Date
GB1139506A true GB1139506A (en) 1969-01-08

Family

ID=10247245

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2666565A Expired GB1139506A (en) 1965-06-23 1965-06-23 Steroid 17-esters

Country Status (10)

Country Link
BE (1) BE682889A (en)
CH (1) CH469691A (en)
DK (1) DK115548B (en)
ES (1) ES328249A1 (en)
FR (1) FR5824M (en)
GB (1) GB1139506A (en)
IL (1) IL25905A (en)
NL (1) NL156143B (en)
NO (1) NO126438B (en)
SE (1) SE331473B (en)

Also Published As

Publication number Publication date
IL25905A (en) 1970-08-19
SE331473B (en) 1971-01-04
DE1568689B2 (en) 1975-07-31
NL156143B (en) 1978-03-15
FR5824M (en) 1968-02-26
BE682889A (en) 1966-12-21
NL6608762A (en) 1966-12-27
DE1568689A1 (en) 1970-06-25
ES328249A1 (en) 1967-04-01
NO126438B (en) 1973-02-05
CH469691A (en) 1969-03-15
DK115548B (en) 1969-10-20

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