GB1133071A - Highly purified gonadotropins and process for the manufacture thereof - Google Patents
Highly purified gonadotropins and process for the manufacture thereofInfo
- Publication number
- GB1133071A GB1133071A GB82/66A GB8266A GB1133071A GB 1133071 A GB1133071 A GB 1133071A GB 82/66 A GB82/66 A GB 82/66A GB 8266 A GB8266 A GB 8266A GB 1133071 A GB1133071 A GB 1133071A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gonadotropins
- buffer
- acetic acid
- sephadex
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000006771 Gonadotropins Human genes 0.000 title abstract 6
- 108010086677 Gonadotropins Proteins 0.000 title abstract 6
- 239000002622 gonadotropin Substances 0.000 title abstract 6
- 229940094892 gonadotropins Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000872 buffer Substances 0.000 abstract 4
- 229920005654 Sephadex Polymers 0.000 abstract 3
- 239000012507 Sephadex™ Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 2
- 239000012153 distilled water Substances 0.000 abstract 2
- 238000005342 ion exchange Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 abstract 1
- BPSNETAIJADFTO-UHFFFAOYSA-N 2-pyridinylacetic acid Chemical compound OC(=O)CC1=CC=CC=N1 BPSNETAIJADFTO-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000011067 equilibration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- AVBGNFCMKJOFIN-UHFFFAOYSA-N triethylammonium acetate Chemical compound CC(O)=O.CCN(CC)CC AVBGNFCMKJOFIN-UHFFFAOYSA-N 0.000 abstract 1
- KYWVDGFGRYJLPE-UHFFFAOYSA-N trimethylazanium;acetate Chemical compound CN(C)C.CC(O)=O KYWVDGFGRYJLPE-UHFFFAOYSA-N 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL6500460A NL6500460A (forum.php) | 1965-01-15 | 1965-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1133071A true GB1133071A (en) | 1968-11-06 |
Family
ID=19792121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB82/66A Expired GB1133071A (en) | 1965-01-15 | 1966-01-03 | Highly purified gonadotropins and process for the manufacture thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3457346A (forum.php) |
| BE (1) | BE675093A (forum.php) |
| CH (1) | CH481146A (forum.php) |
| DE (1) | DE1617661A1 (forum.php) |
| DK (1) | DK114215B (forum.php) |
| ES (1) | ES321509A1 (forum.php) |
| FR (1) | FR1465014A (forum.php) |
| GB (1) | GB1133071A (forum.php) |
| NL (1) | NL6500460A (forum.php) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1717042A1 (de) * | 1963-03-11 | 1972-11-09 | Serono Ist Farm | Verfahren zur Gewinnung von gonadotropen Hypophysenhormonen aus Urin |
| US4033344A (en) * | 1975-04-28 | 1977-07-05 | Jack Owen Reed | Recovery of chorionic gonadotropic hormone from pregnant mares |
| CN114671944A (zh) * | 2022-04-29 | 2022-06-28 | 江苏尤里卡生物科技有限公司 | 一种人绒毛膜促性腺激素纯化方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3119740A (en) * | 1959-04-13 | 1964-01-28 | Armour Pharma | Process for preparing purified follicle stimulating hormone |
| NL124014C (forum.php) * | 1960-08-08 |
-
1965
- 1965-01-15 NL NL6500460A patent/NL6500460A/xx unknown
- 1965-12-13 US US513561A patent/US3457346A/en not_active Expired - Lifetime
-
1966
- 1966-01-03 GB GB82/66A patent/GB1133071A/en not_active Expired
- 1966-01-07 ES ES0321509A patent/ES321509A1/es not_active Expired
- 1966-01-12 FR FR45646A patent/FR1465014A/fr not_active Expired
- 1966-01-13 DE DE19661617661 patent/DE1617661A1/de active Pending
- 1966-01-14 BE BE675093D patent/BE675093A/xx unknown
- 1966-01-15 DK DK23066AA patent/DK114215B/da unknown
- 1966-01-17 CH CH58066A patent/CH481146A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US3457346A (en) | 1969-07-22 |
| ES321509A1 (es) | 1966-10-16 |
| DE1617661A1 (de) | 1971-03-25 |
| CH481146A (de) | 1969-11-15 |
| DK114215B (da) | 1969-06-09 |
| FR1465014A (fr) | 1967-01-06 |
| NL6500460A (forum.php) | 1966-07-18 |
| BE675093A (forum.php) | 1966-07-14 |
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