GB1129072A - Benzofuran and indole derivatives - Google Patents
Benzofuran and indole derivativesInfo
- Publication number
- GB1129072A GB1129072A GB4421/66A GB442166A GB1129072A GB 1129072 A GB1129072 A GB 1129072A GB 4421/66 A GB4421/66 A GB 4421/66A GB 442166 A GB442166 A GB 442166A GB 1129072 A GB1129072 A GB 1129072A
- Authority
- GB
- United Kingdom
- Prior art keywords
- stands
- formula
- radical
- compound
- case
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 6
- 150000002475 indoles Chemical class 0.000 title abstract 3
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 150000001298 alcohols Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003944 halohydrins Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4421/66A GB1129072A (en) | 1966-02-01 | 1966-02-01 | Benzofuran and indole derivatives |
| DE1967J0032795 DE1593901B2 (de) | 1966-02-01 | 1967-01-17 | Basisch substituierte benzofurane oder indole und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| SE01103/67A SE360653B (US07118763-20061010-C00002.png) | 1966-02-01 | 1967-01-25 | |
| CH140167A CH486441A (de) | 1963-07-30 | 1967-01-31 | Verfahren zur Herstellung von Propanolamin-Derivaten |
| CH1629269A CH492696A (de) | 1963-07-30 | 1967-01-31 | Verfahren zur Herstellung von Propanolamin-Derivaten |
| CH1629569A CH489490A (de) | 1963-07-30 | 1967-01-31 | Verfahren zur Herstellung von Propanolamin-Derivaten |
| CH1629469A CH489489A (de) | 1963-07-30 | 1967-01-31 | Verfahren zur Herstellung von Propanolamin-Derivaten |
| CH1629369A CH489488A (de) | 1963-07-30 | 1967-01-31 | Verfahren zur Herstellung von Propanolamin-Derivaten |
| FR93353A FR96649E (US07118763-20061010-C00002.png) | 1966-02-01 | 1967-02-01 | |
| NL6701573A NL6701573A (US07118763-20061010-C00002.png) | 1966-02-01 | 1967-02-01 | |
| BE693518D BE693518A (US07118763-20061010-C00002.png) | 1966-02-01 | 1967-02-01 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4421/66A GB1129072A (en) | 1966-02-01 | 1966-02-01 | Benzofuran and indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1129072A true GB1129072A (en) | 1968-10-02 |
Family
ID=9776870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4421/66A Expired GB1129072A (en) | 1963-07-30 | 1966-02-01 | Benzofuran and indole derivatives |
Country Status (6)
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2059558A1 (US07118763-20061010-C00002.png) * | 1969-07-25 | 1971-06-04 | Sandoz Sa | |
| FR2068461A1 (US07118763-20061010-C00002.png) * | 1969-08-05 | 1971-08-27 | Sandoz Sa | |
| FR2121607A1 (US07118763-20061010-C00002.png) * | 1971-01-07 | 1972-08-25 | Sandoz Sa | |
| JPS4943960A (US07118763-20061010-C00002.png) * | 1972-08-30 | 1974-04-25 | ||
| US4235919A (en) | 1977-07-21 | 1980-11-25 | Sandoz Ltd. | 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof |
| WO1982002550A1 (en) * | 1981-01-16 | 1982-08-05 | Ag Sandoz | Derivatives of 3-aminopropoxy-aryl compounds,preparation thereof and drugs containing them |
| US6022894A (en) * | 1996-04-09 | 2000-02-08 | Nps Pharmaceuticals, Inc. | Method of using calcilytic compounds |
| WO2000037464A2 (en) * | 1998-12-18 | 2000-06-29 | Basilea Pharmaceutica Ag | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
| US6432656B1 (en) | 1996-12-03 | 2002-08-13 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| CN117024880A (zh) * | 2023-09-14 | 2023-11-10 | 美新科技股份有限公司 | 一种耐高温塑木材料组合物及塑木产品 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH495983A (de) * | 1968-02-09 | 1970-09-15 | Sandoz Ag | Verfahren zur Herstellung von linksdrehendem 4-(2-Hydroxy-3-isopropylaminopropoxy)indol |
| FR2019185A1 (en) * | 1968-09-30 | 1970-06-26 | Sandoz Sa | 4-(2-hydroxy-3-amino-propoxy)-indole-2-carboxy- - lic acids and esters and 2-hydroxymethylindoles as beta |
| US3699123A (en) * | 1970-03-24 | 1972-10-17 | Sandoz Ltd | 4-(3-amino-2-hydroxy-propoxy) indole derivatives |
| WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
| EP0013878A1 (en) * | 1979-01-18 | 1980-08-06 | Sandoz Ag | 3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
-
1966
- 1966-02-01 GB GB4421/66A patent/GB1129072A/en not_active Expired
-
1967
- 1967-01-17 DE DE1967J0032795 patent/DE1593901B2/de active Granted
- 1967-01-25 SE SE01103/67A patent/SE360653B/xx unknown
- 1967-02-01 FR FR93353A patent/FR96649E/fr not_active Expired
- 1967-02-01 BE BE693518D patent/BE693518A/xx unknown
- 1967-02-01 NL NL6701573A patent/NL6701573A/xx unknown
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2059558A1 (US07118763-20061010-C00002.png) * | 1969-07-25 | 1971-06-04 | Sandoz Sa | |
| FR2068461A1 (US07118763-20061010-C00002.png) * | 1969-08-05 | 1971-08-27 | Sandoz Sa | |
| FR2121607A1 (US07118763-20061010-C00002.png) * | 1971-01-07 | 1972-08-25 | Sandoz Sa | |
| JPS4943960A (US07118763-20061010-C00002.png) * | 1972-08-30 | 1974-04-25 | ||
| JPS5719110B2 (US07118763-20061010-C00002.png) * | 1972-08-30 | 1982-04-20 | ||
| US4235919A (en) | 1977-07-21 | 1980-11-25 | Sandoz Ltd. | 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof |
| WO1982002550A1 (en) * | 1981-01-16 | 1982-08-05 | Ag Sandoz | Derivatives of 3-aminopropoxy-aryl compounds,preparation thereof and drugs containing them |
| US6521667B1 (en) | 1996-04-09 | 2003-02-18 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US6022894A (en) * | 1996-04-09 | 2000-02-08 | Nps Pharmaceuticals, Inc. | Method of using calcilytic compounds |
| US6818660B2 (en) | 1996-04-09 | 2004-11-16 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US6432656B1 (en) | 1996-12-03 | 2002-08-13 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| US7202261B2 (en) | 1996-12-03 | 2007-04-10 | Nps Pharmaceuticals, Inc. | Calcilytic compounds |
| WO2000037464A2 (en) * | 1998-12-18 | 2000-06-29 | Basilea Pharmaceutica Ag | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
| WO2000037464A3 (en) * | 1998-12-18 | 2000-11-02 | Hoffmann La Roche | 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors |
| US6376491B1 (en) | 1998-12-18 | 2002-04-23 | Basilea Pharmaceutica Ag | Bicyclic compounds |
| CN117024880A (zh) * | 2023-09-14 | 2023-11-10 | 美新科技股份有限公司 | 一种耐高温塑木材料组合物及塑木产品 |
| CN117024880B (zh) * | 2023-09-14 | 2024-05-24 | 美新科技股份有限公司 | 一种耐高温塑木材料组合物及塑木产品 |
Also Published As
| Publication number | Publication date |
|---|---|
| SE360653B (US07118763-20061010-C00002.png) | 1973-10-01 |
| BE693518A (US07118763-20061010-C00002.png) | 1967-08-01 |
| DE1593901A1 (de) | 1970-10-29 |
| FR96649E (US07118763-20061010-C00002.png) | 1976-02-27 |
| DE1593901B2 (de) | 1976-12-23 |
| NL6701573A (US07118763-20061010-C00002.png) | 1967-08-02 |
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