GB1127224A - New antibiotic a3823 and method of making same - Google Patents

New antibiotic a3823 and method of making same

Info

Publication number
GB1127224A
GB1127224A GB4108365A GB4108365A GB1127224A GB 1127224 A GB1127224 A GB 1127224A GB 4108365 A GB4108365 A GB 4108365A GB 4108365 A GB4108365 A GB 4108365A GB 1127224 A GB1127224 A GB 1127224A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
aqueous
animal
sept
chloroform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4108365A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1127224A publication Critical patent/GB1127224A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,127,224. Antibiotic A3823. ELI LILLY & CO. 27 Sept., 1965 [28 Sept., 1964], No. 41083/65. Heading C2A. Antibiotic A3823, effective against bacterial and fungal plant and animal pathogens, is a white crystalline solid melting at 103-106‹ C.; soluble in alcohols, esters, ketones, chloroform, dimethylformamide and dimethyl sulphoxide; insoluble in water; having a titratable group of pK<SP>1</SP>a=6À65 in 66% aqueous dimethylformamide; [α]<SP>25</SP> D of 47.7 degrees in 1% CH 3 OH; empirical formula C 36 H 66 O 12 ; C=62À78%, H= 9.43%, O=26À61%; no absorption in U.V.; I.R. absorption as in Fig. I; stable in aqueous alkali; unstable in aqueous acid. Antibiotic A3823 is produced by cultivating Streptomyces cinnamonensis, e.g. ATCC 15413 or an A3823- producing mutant thereof, in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions. The antibiotic may be recovered from the fermentation broth by the solvent extraction of the whole or clarified broth or the separated mycelium, e.g. extraction of the clarified broth by chloroform at pH 3.0, followed by chromatography on carbon and crystallization from aqueous methanol and then ether-petroleum ether mixture. An animal feed composition comprises an animal feed and antibiotic A3823. The composition may be used in the treatment of coccidiosis in poultry and as an antibacterial and antifungal drug against animal diseases.
GB4108365A 1964-09-28 1965-09-27 New antibiotic a3823 and method of making same Expired GB1127224A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39970664A 1964-09-28 1964-09-28

Publications (1)

Publication Number Publication Date
GB1127224A true GB1127224A (en) 1968-09-18

Family

ID=23580652

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4108365A Expired GB1127224A (en) 1964-09-28 1965-09-27 New antibiotic a3823 and method of making same

Country Status (9)

Country Link
BE (1) BE670210A (en)
BR (1) BR6573551D0 (en)
CH (1) CH457720A (en)
DE (2) DE1467883C3 (en)
DK (1) DK115244B (en)
ES (1) ES317908A1 (en)
FR (1) FR1588155A (en)
GB (1) GB1127224A (en)
NL (1) NL139557B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2131689A (en) * 1982-12-18 1984-06-27 Pfizer Ltd Administering monensin to swine to promote growth and feed efficiency

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4927328B2 (en) * 1972-03-03 1974-07-17

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2131689A (en) * 1982-12-18 1984-06-27 Pfizer Ltd Administering monensin to swine to promote growth and feed efficiency

Also Published As

Publication number Publication date
ES317908A1 (en) 1966-06-16
NL139557B (en) 1973-08-15
DE1793766B2 (en) 1978-03-02
DE1467883B2 (en) 1973-07-12
NL6512545A (en) 1966-03-29
BR6573551D0 (en) 1973-08-02
DE1467883A1 (en) 1969-12-18
DE1467883C3 (en) 1975-08-14
CH457720A (en) 1968-06-15
DE1793766C3 (en) 1978-11-02
FR1588155A (en) 1970-04-10
BE670210A (en)
DE1793766A1 (en) 1973-11-08
DK115244B (en) 1969-09-22

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