GB1117806A - Hexahydro-indenopyridine derivatives - Google Patents
Hexahydro-indenopyridine derivativesInfo
- Publication number
- GB1117806A GB1117806A GB41798/66A GB4179866A GB1117806A GB 1117806 A GB1117806 A GB 1117806A GB 41798/66 A GB41798/66 A GB 41798/66A GB 4179866 A GB4179866 A GB 4179866A GB 1117806 A GB1117806 A GB 1117806A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- salts
- derivatives
- hydrazine
- hexahydroindenopyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel hexahydroindenopyridine derivatives of the formula <FORM:1117806/C2/1> wherein R is a C1- 6 alkyl or C3- 9 cycloalkyl radical and wherein the benzene ring of the indenopyridine nucleus and/or the phenyl radical at the 4a-position may bear one or more substituents and acid addition salts or quaternary ammonium salts thereof are prepared by (a) refluxing the appropriate 3-benzoyl-4-phenyl - 1,2,3,6 - tetrahydropyridines with anhydrous hydrazine, removing excess hydrazine and decomposing the hydrazine derivative produced and cyclising the 3-benzyl-4-phenyl-1,2,5,6-tetrahydropyridines produced with polyphosphoric acid at an elevated temperature not exceeding 150 DEG C. or (b) by reducing the corresponding 9-oxo-hexahydroindenopyridines. The compounds may be separated into two racemates, e.g. by means of their picrate salts. Therapeutic compositions useful as central-nervous-system depressants and as analgesic, anticholinergic and antihistaminic agents contain the above hexahydroindenopyridine derivatives or pharmaceutically acceptable acid addition salts or quaternary ammonium salts thereof as active ingredients. The composition may be in the form of tablets, suspensions, solutions or suppositories.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB41798/66A GB1117806A (en) | 1966-09-19 | 1966-09-19 | Hexahydro-indenopyridine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB41798/66A GB1117806A (en) | 1966-09-19 | 1966-09-19 | Hexahydro-indenopyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1117806A true GB1117806A (en) | 1968-06-26 |
Family
ID=10421414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB41798/66A Expired GB1117806A (en) | 1966-09-19 | 1966-09-19 | Hexahydro-indenopyridine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1117806A (en) |
-
1966
- 1966-09-19 GB GB41798/66A patent/GB1117806A/en not_active Expired
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