ES366535A1 - Substituted esters of phenyl acetic acids - Google Patents

Substituted esters of phenyl acetic acids

Info

Publication number
ES366535A1
ES366535A1 ES366535A ES366535A ES366535A1 ES 366535 A1 ES366535 A1 ES 366535A1 ES 366535 A ES366535 A ES 366535A ES 366535 A ES366535 A ES 366535A ES 366535 A1 ES366535 A1 ES 366535A1
Authority
ES
Spain
Prior art keywords
esters
alkanoic acids
derivatives
compounds
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES366535A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES366535A1 publication Critical patent/ES366535A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of formula wherein R 1 is H, Me or Et, R 2 is H, F, Cl or Br, A is C 2-3 alkylene (with at least 2C atoms between the O and N atoms), and R 3 , R 4 are each C 1-4 alkyl, or NR 3 R 4 is pyrrolidino, piperidino, hexamethyleneimino or morpholino and pharmaceutically acceptable acid addition salts thereof. These compounds are prepared by (a) forming the ester group by standard methods or (b) forming the pyrrole ring by reacting the corresponding precursor having NH 2 instead of 1-pyrryl in the above formula with e.g. succinaldehyde or 2,5-dimethoxytetrahydrofuran. Details are given of the preparation of the following intermediates: 2 - (p - 1 - pyrrylphenyl)alkanoic acids, esters (and 2-carboalkoxy derivatives of the esters) and an acid chloride 2- (p - aminophenyl)alkanoic acids, aminoalkyl and alkyl esters (and their 2-carboalkoxy derivatives) m-chloro derivatives of the foregoing 2-(4- acetamino - 3 - chlorophenyl)alkanoic acids and diethyl 2 - (3 - chloro - 4 - nitrophenyl) - 2- methylmalonate. Therapeutic compositions for oral, rectal, parenteral or local administration comprise compounds of the above formula with a diluent or carrier, and have analgetic, antiphlogistic and musculotropic-spasmolytic activity.
ES366535A 1968-04-29 1969-04-28 Substituted esters of phenyl acetic acids Expired ES366535A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH637768A CH502334A (en) 1968-04-29 1968-04-29 Process for the preparation of new esters of substituted phenylacetic acids

Publications (1)

Publication Number Publication Date
ES366535A1 true ES366535A1 (en) 1971-01-01

Family

ID=4308611

Family Applications (2)

Application Number Title Priority Date Filing Date
ES366536A Expired ES366536A1 (en) 1968-04-29 1969-04-28 Substituted esters of phenyl acetic acids
ES366535A Expired ES366535A1 (en) 1968-04-29 1969-04-28 Substituted esters of phenyl acetic acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES366536A Expired ES366536A1 (en) 1968-04-29 1969-04-28 Substituted esters of phenyl acetic acids

Country Status (16)

Country Link
US (2) US3697460A (en)
AT (2) AT286975B (en)
BE (1) BE732235A (en)
BG (3) BG15388A3 (en)
BR (1) BR6908404D0 (en)
CH (3) CH502336A (en)
DE (1) DE1921652A1 (en)
DK (1) DK125591B (en)
ES (2) ES366536A1 (en)
FR (1) FR2007553A1 (en)
GB (1) GB1263782A (en)
IL (1) IL32084A (en)
NL (1) NL6906207A (en)
NO (1) NO127005B (en)
PL (1) PL69820B1 (en)
SE (1) SE342621B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008014450A (en) 2006-05-18 2009-03-09 Mannkind Corp Intracellular kinase inhibitors.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2986564A (en) * 1959-02-20 1961-05-30 Rips Richard Pyrrole compounds

Also Published As

Publication number Publication date
CH502336A (en) 1971-01-31
AT290521B (en) 1971-06-11
ES366536A1 (en) 1971-01-01
AT286975B (en) 1971-01-11
CH503726A (en) 1971-02-28
NL6906207A (en) 1969-10-31
NO127005B (en) 1973-04-24
US3767802A (en) 1973-10-23
BE732235A (en) 1969-10-28
IL32084A (en) 1973-01-30
BG15550A3 (en) 1972-05-20
DK125591B (en) 1973-03-12
SE342621B (en) 1972-02-14
BG15388A3 (en) 1976-05-10
GB1263782A (en) 1972-02-16
US3697460A (en) 1972-10-10
BR6908404D0 (en) 1973-01-11
DE1921652A1 (en) 1969-11-13
BG15209A3 (en) 1975-10-15
IL32084A0 (en) 1969-06-25
FR2007553A1 (en) 1970-01-09
PL69820B1 (en) 1973-10-31
CH502334A (en) 1971-01-31

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