GB1117637A - Derivatives of the antibiotic circulin - Google Patents

Derivatives of the antibiotic circulin

Info

Publication number
GB1117637A
GB1117637A GB5209865A GB5209865A GB1117637A GB 1117637 A GB1117637 A GB 1117637A GB 5209865 A GB5209865 A GB 5209865A GB 5209865 A GB5209865 A GB 5209865A GB 1117637 A GB1117637 A GB 1117637A
Authority
GB
United Kingdom
Prior art keywords
circulin
pentakis
sulphomethyl
hydroxymethyl
ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5209865A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1117637A publication Critical patent/GB1117637A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention comprises pentakis - [N-(hydroxymethyl)] circulin and pentakis-[N-(sulphomethyl)] circulin, and their pharmacologically acceptable metal, ammonium, and amine salts. Pentakis-[N-(hydroxymethyl)] circulin is prepared by reacting circulin sulphate and formaldehyde in aqueous solution, when the said derivative being water-insoluble, precipitates out. The sulphomethyl compound is prepared by reacting pentakis-[N-(hydroxymethyl)] circulin with an aqueous solution of an alkali metal or ammonium bisulphite, to give the corresponding salt of the sulphomethyl compound which may be isolated by freeze-drying the solution. Free acid pentakis-[N-(sulphomethyl)] circulin may be obtained by treatment of these salts with acid, or a cation exchange resin at acidic pH. Also prepared by identical procedures are the hydroxymethyl and sulphomethyl derivatives of Circulins A and B. Pharmaceutical compositions having anti-bacterial activity comprise one of the inventive compounds together with a pharmaceutically acceptable carrier.ALSO:Pentakis-[N-(hydroxymethyl)] circulin and pentakis-[N-(sulphomethyl)] circulin, derived from the antibiotic circulin, (see Divisions C2) or their pharmaceutically acceptable alkali metal, ammonium, or amine salts, are of use in treating fish meal to prevent contamination by Salmonella.ALSO:Pentakis - [N - (hydroxymethyl)] circulin and pentakis - [N - (sulphomethyl)] circulin, derived from the antibiotic circulin, (see Division C2), or their pharmaceutically acceptable alkali, metal, ammonium, or amine salts, are of use in paper mill systems to prevent the growth of E coli.
GB5209865A 1965-01-25 1965-12-08 Derivatives of the antibiotic circulin Expired GB1117637A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42795765A 1965-01-25 1965-01-25

Publications (1)

Publication Number Publication Date
GB1117637A true GB1117637A (en) 1968-06-19

Family

ID=23696999

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5209865A Expired GB1117637A (en) 1965-01-25 1965-12-08 Derivatives of the antibiotic circulin

Country Status (2)

Country Link
FR (1) FR5578M (en)
GB (1) GB1117637A (en)

Also Published As

Publication number Publication date
FR5578M (en) 1967-11-27
DE1543936B2 (en) 1973-01-04
DE1543936A1 (en) 1970-05-21

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