GB1116330A - Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof - Google Patents

Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof

Info

Publication number
GB1116330A
GB1116330A GB3512767A GB3512767A GB1116330A GB 1116330 A GB1116330 A GB 1116330A GB 3512767 A GB3512767 A GB 3512767A GB 3512767 A GB3512767 A GB 3512767A GB 1116330 A GB1116330 A GB 1116330A
Authority
GB
United Kingdom
Prior art keywords
phenylisoxazole
piperidinopropionyl
preparation
morpholinopropionyl
quaternary ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3512767A
Inventor
Hideo Kano
Ikudo Adachi
Ryonosuke Kido
Katsumi Hirose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to GB3889567A priority Critical patent/GB1125360A/en
Priority to GB3512767A priority patent/GB1116330A/en
Publication of GB1116330A publication Critical patent/GB1116330A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention comprises (1) the novel compound 3 - (3 - piperidinopropionyl) - 5 - phenylisoxazole, and the non-toxic acid addition and quaternary ammonium salts thereof; (2) the preparation of 3-(3-piperidinopropionyl)- and 3 - (3 - morpholinopropionyl) - 5 - phenylisoxazole by reacting 3 - (3 - chloropropionyl)-5-phenylisoxazole with morpholine or piperidine; and (3) the non-toxic acid addition and quaternary ammonium salts of 3-(3-piperidinopropionyl) - and 3 - (3 - morpholinopropionyl)-5-phenylisoxazole when prepared by the process given under (2) above. Therapeutic compositions having anti-pyretic, analgesic, anti-tussive and anti-inflammatory activity, contain, as active ingredient, 3-(3-piperidinopropionyl) - 5 - phenylisoxazole or 3-(3 - morpholinopropionyl) - 5 - phenylisoxazole or non-toxic, pharmaceutically acceptable acid addition or quaternary ammonium salts thereof.
GB3512767A 1966-02-25 1966-02-25 Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof Expired GB1116330A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3889567A GB1125360A (en) 1966-02-25 1966-02-25 Isoxazole compounds and non-toxic salts thereof
GB3512767A GB1116330A (en) 1966-02-25 1966-02-25 Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3512767A GB1116330A (en) 1966-02-25 1966-02-25 Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof

Publications (1)

Publication Number Publication Date
GB1116330A true GB1116330A (en) 1968-06-06

Family

ID=10374154

Family Applications (2)

Application Number Title Priority Date Filing Date
GB3889567A Expired GB1125360A (en) 1966-02-25 1966-02-25 Isoxazole compounds and non-toxic salts thereof
GB3512767A Expired GB1116330A (en) 1966-02-25 1966-02-25 Disubstituted isoxazole compounds their non-toxic salts and the preparation thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB3889567A Expired GB1125360A (en) 1966-02-25 1966-02-25 Isoxazole compounds and non-toxic salts thereof

Country Status (1)

Country Link
GB (2) GB1125360A (en)

Also Published As

Publication number Publication date
GB1125360A (en) 1968-08-28

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