GB1105994A - 20'-hydroxy-voacamidine, its extraction and composition containing same - Google Patents
20'-hydroxy-voacamidine, its extraction and composition containing sameInfo
- Publication number
- GB1105994A GB1105994A GB3995766A GB3995766A GB1105994A GB 1105994 A GB1105994 A GB 1105994A GB 3995766 A GB3995766 A GB 3995766A GB 3995766 A GB3995766 A GB 3995766A GB 1105994 A GB1105994 A GB 1105994A
- Authority
- GB
- United Kingdom
- Prior art keywords
- voacamidine
- hydroxy
- acid addition
- toxic acid
- distribution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- PSTDKFQDHNZGAL-JAHAZDFLSA-N Voacamidine Natural products CCC1CC2CN3CCc4c([nH]c5ccc(OC)c(C6CC7C(C(Cc8c6[nH]c9ccccc89)N(C)C/C/7=C/C)C(=O)OC)c45)C(C2)(C13)C(=O)OC PSTDKFQDHNZGAL-JAHAZDFLSA-N 0.000 abstract 1
- 241001246849 Voacanga africana Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- -1 halogen hydrocarbon Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 239000012074 organic phase Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008363 phosphate buffer Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- KQFGPIYUBNBTND-UHFFFAOYSA-N voacamine Natural products CCC1CC2CN3CCc4c([nH]c5c(cc(OC)cc45)C6CC7C(C(Cc8c6[nH]c9ccccc89)N(C)C/C/7=CC)C(=O)OC)C(C2)(C13)C(=O)OC KQFGPIYUBNBTND-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1252765 | 1965-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1105994A true GB1105994A (en) | 1968-03-13 |
Family
ID=4383858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3995766A Expired GB1105994A (en) | 1965-09-08 | 1966-09-07 | 20'-hydroxy-voacamidine, its extraction and composition containing same |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | AT269365B (en:Method) |
| BE (1) | BE686542A (en:Method) |
| ES (1) | ES330981A1 (en:Method) |
| GB (1) | GB1105994A (en:Method) |
| NL (1) | NL6612608A (en:Method) |
-
1966
- 1966-09-07 NL NL6612608A patent/NL6612608A/xx unknown
- 1966-09-07 AT AT845166A patent/AT269365B/de active
- 1966-09-07 BE BE686542D patent/BE686542A/xx unknown
- 1966-09-07 GB GB3995766A patent/GB1105994A/en not_active Expired
- 1966-09-07 ES ES0330981A patent/ES330981A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE686542A (en:Method) | 1967-03-07 |
| ES330981A1 (es) | 1967-07-01 |
| AT269365B (de) | 1969-03-10 |
| NL6612608A (en:Method) | 1967-03-09 |
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