GB1104655A - Tetracycline derivatives and process for their preparation - Google Patents

Tetracycline derivatives and process for their preparation

Info

Publication number
GB1104655A
GB1104655A GB3266165A GB3266165A GB1104655A GB 1104655 A GB1104655 A GB 1104655A GB 3266165 A GB3266165 A GB 3266165A GB 3266165 A GB3266165 A GB 3266165A GB 1104655 A GB1104655 A GB 1104655A
Authority
GB
United Kingdom
Prior art keywords
tetracycline
derivatives
antibiotic
sulphonic acid
inorganic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3266165A
Inventor
Victor Armand
Philippe Rohrbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LAB BOTTU SOC D EXPL DES
Original Assignee
LAB BOTTU SOC D EXPL DES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LAB BOTTU SOC D EXPL DES filed Critical LAB BOTTU SOC D EXPL DES
Priority to GB3266165A priority Critical patent/GB1104655A/en
Priority to FR70362A priority patent/FR1489927A/en
Priority to CH1094566A priority patent/CH458335A/en
Priority to BR18167466A priority patent/BR6681674D0/en
Priority to BE684849D priority patent/BE684849A/xx
Priority to DE19661593403 priority patent/DE1593403A1/en
Priority to FR80562A priority patent/FR5755M/fr
Publication of GB1104655A publication Critical patent/GB1104655A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to derivatives of a tetracycline antibiotic, probably of formula <FORM:1104655/C2/1> wherein n is 3 or 4 and T is a decarbamoylated radical of a tetracycline antibiotic (especially tetracycline, oxytetracycline, chlortetracycline or demethylchlortetracycline), which derivatives are produced by reacting an internal ester of a hydroxyalkyl sulphonic acid of formula <FORM:1104655/C2/2> wherein n is 3 or 4, with a tetracycline antibiotic. In the case of chloropropane sulphonic acid and chlorobutane sulphonic acid salts, the hydrochloride of the antibiotic is reacted with two moles of the appropriate internal ester. In general, salts are formed with inorganic and organic acids (e.g. aryl or alkyl sulphonic acids) and with inorganic and organic bases (e.g. triethylamine and D(-)a -aminobenzyl penicillin). The compounds are stable and have antibacterial and antibacteriostatic properties. Pharmaceutical compositions for oral, parenteral or topical administration to humans or animals comprise one or more of the above tetracycline derivatives.
GB3266165A 1965-07-30 1965-07-30 Tetracycline derivatives and process for their preparation Expired GB1104655A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB3266165A GB1104655A (en) 1965-07-30 1965-07-30 Tetracycline derivatives and process for their preparation
FR70362A FR1489927A (en) 1965-07-30 1966-07-21 Process for the preparation of new derivatives of the tetracycline series
CH1094566A CH458335A (en) 1965-07-30 1966-07-28 Process for the preparation of novel tetracycline derivatives
BR18167466A BR6681674D0 (en) 1965-07-30 1966-07-29 NEW DERIVATIVES FROM THE TETRACYCLINE SERIES AND PREPARATION PROCESS
BE684849D BE684849A (en) 1965-07-30 1966-07-29
DE19661593403 DE1593403A1 (en) 1965-07-30 1966-07-29 Process for the preparation of sulfonic acid derivatives of the tetracyclines
FR80562A FR5755M (en) 1965-07-30 1966-10-19

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3266165A GB1104655A (en) 1965-07-30 1965-07-30 Tetracycline derivatives and process for their preparation

Publications (1)

Publication Number Publication Date
GB1104655A true GB1104655A (en) 1968-02-28

Family

ID=10342095

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3266165A Expired GB1104655A (en) 1965-07-30 1965-07-30 Tetracycline derivatives and process for their preparation

Country Status (6)

Country Link
BE (1) BE684849A (en)
BR (1) BR6681674D0 (en)
CH (1) CH458335A (en)
DE (1) DE1593403A1 (en)
FR (1) FR5755M (en)
GB (1) GB1104655A (en)

Also Published As

Publication number Publication date
BE684849A (en) 1967-01-03
FR5755M (en) 1968-01-29
BR6681674D0 (en) 1973-10-25
CH458335A (en) 1968-06-30
DE1593403A1 (en) 1970-07-16

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