GB1104655A - Tetracycline derivatives and process for their preparation - Google Patents
Tetracycline derivatives and process for their preparationInfo
- Publication number
- GB1104655A GB1104655A GB3266165A GB3266165A GB1104655A GB 1104655 A GB1104655 A GB 1104655A GB 3266165 A GB3266165 A GB 3266165A GB 3266165 A GB3266165 A GB 3266165A GB 1104655 A GB1104655 A GB 1104655A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetracycline
- derivatives
- antibiotic
- sulphonic acid
- inorganic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 3
- 229960002180 tetracycline Drugs 0.000 title abstract 3
- 235000019364 tetracycline Nutrition 0.000 title abstract 3
- 229930101283 tetracycline Natural products 0.000 title abstract 3
- 150000003522 tetracyclines Chemical class 0.000 title abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 229940072172 tetracycline antibiotic Drugs 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 abstract 1
- NQAWQSVOOHTLEY-UHFFFAOYSA-N 1-chlorobutane-1-sulfonic acid Chemical class CCCC(Cl)S(O)(=O)=O NQAWQSVOOHTLEY-UHFFFAOYSA-N 0.000 abstract 1
- MCXZBEZHTYZNRE-UHFFFAOYSA-N 1-chloropropane-1-sulfonic acid Chemical compound CCC(Cl)S(O)(=O)=O MCXZBEZHTYZNRE-UHFFFAOYSA-N 0.000 abstract 1
- 239000004099 Chlortetracycline Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004475 chlortetracycline Drugs 0.000 abstract 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 1
- 235000019365 chlortetracycline Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960002398 demeclocycline Drugs 0.000 abstract 1
- -1 hydroxyalkyl sulphonic acid Chemical compound 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3266165A GB1104655A (en) | 1965-07-30 | 1965-07-30 | Tetracycline derivatives and process for their preparation |
| FR70362A FR1489927A (fr) | 1965-07-30 | 1966-07-21 | Procédé de préparation de nouveaux dérivés de la série de tétracyclines |
| CH1094566A CH458335A (fr) | 1965-07-30 | 1966-07-28 | Procédé de préparation de nouveaux dérivés des tétracyclines |
| BR18167466A BR6681674D0 (pt) | 1965-07-30 | 1966-07-29 | Novos derivados da serie das tetraciclinas e processo de preparacao |
| BE684849D BE684849A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1965-07-30 | 1966-07-29 | |
| DE19661593403 DE1593403A1 (de) | 1965-07-30 | 1966-07-29 | Verfahren zur Herstellung von Sulfonsaeurederivaten der Tetracycline |
| FR80562A FR5755M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1965-07-30 | 1966-10-19 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3266165A GB1104655A (en) | 1965-07-30 | 1965-07-30 | Tetracycline derivatives and process for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1104655A true GB1104655A (en) | 1968-02-28 |
Family
ID=10342095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3266165A Expired GB1104655A (en) | 1965-07-30 | 1965-07-30 | Tetracycline derivatives and process for their preparation |
Country Status (6)
-
1965
- 1965-07-30 GB GB3266165A patent/GB1104655A/en not_active Expired
-
1966
- 1966-07-28 CH CH1094566A patent/CH458335A/fr unknown
- 1966-07-29 BR BR18167466A patent/BR6681674D0/pt unknown
- 1966-07-29 BE BE684849D patent/BE684849A/xx unknown
- 1966-07-29 DE DE19661593403 patent/DE1593403A1/de active Pending
- 1966-10-19 FR FR80562A patent/FR5755M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1593403A1 (de) | 1970-07-16 |
| BE684849A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-01-03 |
| BR6681674D0 (pt) | 1973-10-25 |
| FR5755M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-01-29 |
| CH458335A (fr) | 1968-06-30 |
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