GB1097168A - Novel isoindoline derivatives and a process for the manufacture thereof - Google Patents
Novel isoindoline derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1097168A GB1097168A GB4040066A GB4040066A GB1097168A GB 1097168 A GB1097168 A GB 1097168A GB 4040066 A GB4040066 A GB 4040066A GB 4040066 A GB4040066 A GB 4040066A GB 1097168 A GB1097168 A GB 1097168A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- prepared
- formula
- isoindoline derivatives
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
Abstract
Novel isoindoline derivatives of formula <FORM:1097168/C2/1> and acid addition salts thereof, where S1 and S2 each represent optical substitution by one or more halo, C1- 7 alkyl, C1- 7 alkoxy, hydroxy, sulphonyl, sulphinyl, sulphamyl, C1- 7 alkylmercapto, C1- 7 alkylamino, di(C1- 7 alkyl)-amino, acylamino and/or CF3 substituents, R is C1- 7 alkyl and B is a straight or branched chain C2- 12 alkylene group in which part or all of the carbon atoms may form a 3- to 7-membered carbocylic ring, are prepared by reaction of the diamine H2N-B-NH2 with a diester of formula <FORM:1097168/C2/2> wherein X is halogen, mesyloxy or tosyloxy. which may have been prepared in situ from the corresponding diol. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral administration comprise an above novel compound and a compatible pharmaceutical carrier and have anti-depressant and anorexigenic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48761965A | 1965-09-15 | 1965-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1097168A true GB1097168A (en) | 1967-12-29 |
Family
ID=23936475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4040066A Expired GB1097168A (en) | 1965-09-15 | 1966-09-09 | Novel isoindoline derivatives and a process for the manufacture thereof |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE686723A (en) |
| CH (1) | CH474508A (en) |
| DE (1) | DE1695153C3 (en) |
| ES (1) | ES331207A1 (en) |
| FR (1) | FR5618M (en) |
| GB (1) | GB1097168A (en) |
| IL (1) | IL26428A (en) |
| MY (1) | MY6900038A (en) |
| SE (1) | SE320665B (en) |
-
1966
- 1966-08-29 CH CH1248666A patent/CH474508A/en not_active IP Right Cessation
- 1966-08-31 IL IL2642866A patent/IL26428A/en unknown
- 1966-08-31 DE DE1966H0060385 patent/DE1695153C3/en not_active Expired
- 1966-09-07 FR FR75468A patent/FR5618M/fr not_active Expired
- 1966-09-09 GB GB4040066A patent/GB1097168A/en not_active Expired
- 1966-09-12 SE SE1224566A patent/SE320665B/xx unknown
- 1966-09-12 BE BE686723D patent/BE686723A/xx unknown
- 1966-09-14 ES ES0331207A patent/ES331207A1/en not_active Expired
-
1969
- 1969-12-30 MY MY38/69A patent/MY6900038A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE686723A (en) | 1967-02-15 |
| DE1695153C3 (en) | 1978-03-30 |
| DE1695153A1 (en) | 1970-12-17 |
| ES331207A1 (en) | 1967-11-01 |
| SE320665B (en) | 1970-02-16 |
| MY6900038A (en) | 1969-12-31 |
| CH474508A (en) | 1969-06-30 |
| DE1695153B2 (en) | 1977-08-04 |
| IL26428A (en) | 1970-07-19 |
| FR5618M (en) | 1967-12-11 |
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