GB1095883A - Phenylacetic acid amide derivatives and isoquinolines obtained therefrom - Google Patents
Phenylacetic acid amide derivatives and isoquinolines obtained therefromInfo
- Publication number
- GB1095883A GB1095883A GB15455/67A GB1545567A GB1095883A GB 1095883 A GB1095883 A GB 1095883A GB 15455/67 A GB15455/67 A GB 15455/67A GB 1545567 A GB1545567 A GB 1545567A GB 1095883 A GB1095883 A GB 1095883A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- hydrogen
- acid amide
- phenylacetic acid
- amide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LSBDFXRDZJMBSC-UHFFFAOYSA-N 2-phenylacetamide Chemical class NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002537 isoquinolines Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910010084 LiAlH4 Inorganic materials 0.000 abstract 1
- 229910019201 POBr3 Inorganic materials 0.000 abstract 1
- 229910019213 POCl3 Inorganic materials 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- HEBMCVBCEDMUOF-UHFFFAOYSA-N isochromane Chemical compound C1=CC=C2COCCC2=C1 HEBMCVBCEDMUOF-UHFFFAOYSA-N 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical class OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000075 primary alcohol group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR963667A FR1493408A (fr) | 1964-02-13 | 1964-02-13 | Nouveau procédé de préparation d'alcaloïdes tétracycliques dérivés de l'isoquinoléine et produits obtenus dans ce procédé |
| FR997A FR90553E (fr) | 1964-02-13 | 1965-01-06 | Nouveau procédé de préparation d'alcaloïdes tétracycliques dérivés de l'isoquinoléine et produits obtenus dans ce procédé |
| FR3343 | 1965-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1095883A true GB1095883A (en) | 1967-12-20 |
Family
ID=27241841
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15455/67A Expired GB1095883A (en) | 1964-02-13 | 1965-02-12 | Phenylacetic acid amide derivatives and isoquinolines obtained therefrom |
| GB15454/67A Expired GB1095882A (en) | 1964-02-13 | 1965-02-12 | Substituted isochromans |
| GB6244/65A Expired GB1095881A (en) | 1964-02-13 | 1965-02-12 | Berbine derivatives and process for the preparation thereof |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15454/67A Expired GB1095882A (en) | 1964-02-13 | 1965-02-12 | Substituted isochromans |
| GB6244/65A Expired GB1095881A (en) | 1964-02-13 | 1965-02-12 | Berbine derivatives and process for the preparation thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3426027A (enExample) |
| BR (1) | BR6567094D0 (enExample) |
| CH (2) | CH470393A (enExample) |
| DE (1) | DE1620147B1 (enExample) |
| FR (3) | FR1493408A (enExample) |
| GB (3) | GB1095883A (enExample) |
| IL (5) | IL31264A (enExample) |
| NL (2) | NL6501747A (enExample) |
| SE (1) | SE306091B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539642A (en) * | 1967-07-19 | 1970-11-10 | Geigy Chem Corp | 2-phenyl-2-(1-naphthyl)acetamides |
| US3755330A (en) * | 1967-08-25 | 1973-08-28 | Sandoz Ag | 1-{60 -hydroxybenzyl 3-methyl, 1,2,3,4-tetrahydroiso quinolino-2-carbonitriles |
| US4013666A (en) * | 1976-03-15 | 1977-03-22 | G. D. Searle & Co. | (8α,13Aβ)-8-CARBOCYCLIC/CARBOCYCLIC METHYL-5,8,13,13A-TETRAHYDRO-2,3,10,11-TETRAMETHOXY-6H-dibenzo[a,g]quinolizines and intermediates thereto |
| US4087426A (en) * | 1976-08-16 | 1978-05-02 | Research Corporation | Oxybisberberine and a process for its production |
| IE55519B1 (en) * | 1982-05-14 | 1990-10-10 | Maroko Peter R | Use of a protoberberine alkaloid and composition containing same |
| FR2537583B1 (fr) * | 1982-12-14 | 1985-08-09 | Urpha | Enantiomeres levogyres des derives de la tetrahydro-5, 6, 13, 13a 8h-dibenzo (a,g-) quinolizine, procedes d'obtention, compositions pharmaceutiques les contenant et application |
| CN102796096B (zh) * | 2011-05-27 | 2016-09-14 | 中国科学院上海药物研究所 | 六氢二苯并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用 |
| US11731965B2 (en) | 2017-08-14 | 2023-08-22 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3103513A (en) * | 1963-09-10 | Process for preparing hexadehy- | ||
| US2634292A (en) * | 1950-05-27 | 1953-04-07 | Hoffmann La Roche | Cyclohexenyl ethyl amine and process for the manufacture thereof |
| US2683713A (en) * | 1951-02-16 | 1954-07-13 | Lilly Co Eli | Substituted benzylisoquinolines |
| US3272707A (en) * | 1964-07-17 | 1966-09-13 | Smith Kline French Lab | Pharmaceutical compositions and methods for their use |
-
0
- NL NL129028D patent/NL129028C/xx active
-
1964
- 1964-02-13 FR FR963667A patent/FR1493408A/fr not_active Expired
-
1965
- 1965-01-06 FR FR997A patent/FR90553E/fr not_active Expired
- 1965-02-08 IL IL31264A patent/IL31264A/xx unknown
- 1965-02-08 IL IL22941A patent/IL22941A/en unknown
- 1965-02-08 IL IL31263A patent/IL31263A/xx unknown
- 1965-02-08 IL IL31265A patent/IL31265A/en unknown
- 1965-02-11 BR BR167094/65A patent/BR6567094D0/pt unknown
- 1965-02-11 CH CH638967A patent/CH470393A/fr not_active IP Right Cessation
- 1965-02-11 CH CH185265A patent/CH437330A/fr unknown
- 1965-02-12 GB GB15455/67A patent/GB1095883A/en not_active Expired
- 1965-02-12 NL NL6501747A patent/NL6501747A/xx unknown
- 1965-02-12 GB GB15454/67A patent/GB1095882A/en not_active Expired
- 1965-02-12 US US432409A patent/US3426027A/en not_active Expired - Lifetime
- 1965-02-12 SE SE1885/65A patent/SE306091B/xx unknown
- 1965-02-12 GB GB6244/65A patent/GB1095881A/en not_active Expired
- 1965-02-12 DE DE1965R0039899 patent/DE1620147B1/de not_active Withdrawn
- 1965-02-24 FR FR684465A patent/FR4771M/fr not_active Expired
-
1968
- 1968-12-12 IL IL31265A patent/IL31265A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE306091B (enExample) | 1968-11-18 |
| FR90553E (fr) | 1968-01-05 |
| NL129028C (enExample) | |
| BR6567094D0 (pt) | 1973-12-26 |
| IL22941A (en) | 1969-02-27 |
| GB1095882A (en) | 1967-12-20 |
| IL31264A (en) | 1969-06-25 |
| CH437330A (fr) | 1967-06-15 |
| FR4771M (fr) | 1967-02-27 |
| IL31265A (en) | 1969-11-12 |
| GB1095881A (en) | 1967-12-20 |
| US3426027A (en) | 1969-02-04 |
| IL31265A0 (en) | 1969-02-27 |
| IL31263A (en) | 1969-07-30 |
| FR1493408A (fr) | 1967-09-01 |
| DE1620147B1 (de) | 1972-05-31 |
| NL6501747A (enExample) | 1965-08-16 |
| CH470393A (fr) | 1969-03-31 |
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