GB1091046A - Production of 6-demethyltetracyclines - Google Patents
Production of 6-demethyltetracyclinesInfo
- Publication number
- GB1091046A GB1091046A GB20660/67A GB2066067A GB1091046A GB 1091046 A GB1091046 A GB 1091046A GB 20660/67 A GB20660/67 A GB 20660/67A GB 2066067 A GB2066067 A GB 2066067A GB 1091046 A GB1091046 A GB 1091046A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fermentation
- added
- aminobenzene
- sulphonyl
- fermentation medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/485—Streptomyces aureofaciens
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
6-Demethyltetracycline antibiotics, e.g. 6-demethyl chlortetracycline are produced by culturing a tetracycline-antibiotic-producing strain of a species of the genus Streptomyces in a nutrient medium containing assimilable carbon and nitrogen sources, a methylation inhibitor being added to the fermentation medium gradually so that the ratio of the amount of nucleic acids and proteins formed related to that of the inhibitor added is maintained substantially constant during the course of the fermentation. The methylation inhibitor may be a compound of general formula <FORM:1091046/C2/1> where R is a substituted or unsubstituted guanidine, thiazole, pyrimidine or pyrazine radical, e.g. p-aminobenzene sulphonyl guanidine, 2 - (p - aminobenzene sulphonyl) - 4,6-dimethyl pyrimidine, 2-(p-aminobenzene sulphonyl) - 6 - methoxy - pyridazine and 2 - (p-aminobenzene sulphonyl) - 4 - methyl - thiazole. For the production of 6-dimethyl chlorotetracycline or 6-demethylbromotetracycline, the fermentation medium contains chloride or bromide ions respectively in an amount greater than 50g /ml. If 6-demethyltetracycline is desired, the fermentation medium should contain less than 50 g /ml. of chloride or bromide ions and/or contain chlorination or bromination inhibitors. Preferably, the whole of the methylation inhibitor is added during the first 24 hours of fermentation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUCI000479 | 1963-11-05 | ||
| HUCI000480 | 1963-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1091046A true GB1091046A (en) | 1967-11-15 |
Family
ID=26318372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44991/64A Expired GB1091045A (en) | 1963-11-05 | 1964-11-04 | Production of 6-demethyltetracycline |
| GB20660/67A Expired GB1091046A (en) | 1963-11-05 | 1964-11-04 | Production of 6-demethyltetracyclines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB44991/64A Expired GB1091045A (en) | 1963-11-05 | 1964-11-04 | Production of 6-demethyltetracycline |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT264710B (en) |
| DE (1) | DE1467833C3 (en) |
| DK (1) | DK129243B (en) |
| GB (2) | GB1091045A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110699314A (en) * | 2019-10-22 | 2020-01-17 | 河北圣雪大成制药有限责任公司 | Method for producing 6-demethyltetracycline by fermentation |
-
1964
- 1964-11-03 AT AT930464A patent/AT264710B/en active
- 1964-11-04 GB GB44991/64A patent/GB1091045A/en not_active Expired
- 1964-11-04 GB GB20660/67A patent/GB1091046A/en not_active Expired
- 1964-11-04 DE DE1467833A patent/DE1467833C3/en not_active Expired
- 1964-11-04 DK DK543564AA patent/DK129243B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110699314A (en) * | 2019-10-22 | 2020-01-17 | 河北圣雪大成制药有限责任公司 | Method for producing 6-demethyltetracycline by fermentation |
Also Published As
| Publication number | Publication date |
|---|---|
| AT264710B (en) | 1968-09-10 |
| DE1467833A1 (en) | 1968-11-28 |
| DE1467833B2 (en) | 1973-10-04 |
| GB1091045A (en) | 1967-11-15 |
| DK129243C (en) | 1975-02-03 |
| DK129243B (en) | 1974-09-16 |
| DE1467833C3 (en) | 1974-05-02 |
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