GB1091046A - Production of 6-demethyltetracyclines - Google Patents

Production of 6-demethyltetracyclines

Info

Publication number
GB1091046A
GB1091046A GB20660/67A GB2066067A GB1091046A GB 1091046 A GB1091046 A GB 1091046A GB 20660/67 A GB20660/67 A GB 20660/67A GB 2066067 A GB2066067 A GB 2066067A GB 1091046 A GB1091046 A GB 1091046A
Authority
GB
United Kingdom
Prior art keywords
fermentation
added
aminobenzene
sulphonyl
fermentation medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20660/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1091046A publication Critical patent/GB1091046A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces
    • C12R2001/485Streptomyces aureofaciens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

6-Demethyltetracycline antibiotics, e.g. 6-demethyl chlortetracycline are produced by culturing a tetracycline-antibiotic-producing strain of a species of the genus Streptomyces in a nutrient medium containing assimilable carbon and nitrogen sources, a methylation inhibitor being added to the fermentation medium gradually so that the ratio of the amount of nucleic acids and proteins formed related to that of the inhibitor added is maintained substantially constant during the course of the fermentation. The methylation inhibitor may be a compound of general formula <FORM:1091046/C2/1> where R is a substituted or unsubstituted guanidine, thiazole, pyrimidine or pyrazine radical, e.g. p-aminobenzene sulphonyl guanidine, 2 - (p - aminobenzene sulphonyl) - 4,6-dimethyl pyrimidine, 2-(p-aminobenzene sulphonyl) - 6 - methoxy - pyridazine and 2 - (p-aminobenzene sulphonyl) - 4 - methyl - thiazole. For the production of 6-dimethyl chlorotetracycline or 6-demethylbromotetracycline, the fermentation medium contains chloride or bromide ions respectively in an amount greater than 50g /ml. If 6-demethyltetracycline is desired, the fermentation medium should contain less than 50 g /ml. of chloride or bromide ions and/or contain chlorination or bromination inhibitors. Preferably, the whole of the methylation inhibitor is added during the first 24 hours of fermentation.
GB20660/67A 1963-11-05 1964-11-04 Production of 6-demethyltetracyclines Expired GB1091046A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUCI000479 1963-11-05
HUCI000480 1963-11-06

Publications (1)

Publication Number Publication Date
GB1091046A true GB1091046A (en) 1967-11-15

Family

ID=26318372

Family Applications (2)

Application Number Title Priority Date Filing Date
GB44991/64A Expired GB1091045A (en) 1963-11-05 1964-11-04 Production of 6-demethyltetracycline
GB20660/67A Expired GB1091046A (en) 1963-11-05 1964-11-04 Production of 6-demethyltetracyclines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB44991/64A Expired GB1091045A (en) 1963-11-05 1964-11-04 Production of 6-demethyltetracycline

Country Status (4)

Country Link
AT (1) AT264710B (en)
DE (1) DE1467833C3 (en)
DK (1) DK129243B (en)
GB (2) GB1091045A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110699314A (en) * 2019-10-22 2020-01-17 河北圣雪大成制药有限责任公司 Method for producing 6-demethyltetracycline by fermentation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110699314A (en) * 2019-10-22 2020-01-17 河北圣雪大成制药有限责任公司 Method for producing 6-demethyltetracycline by fermentation

Also Published As

Publication number Publication date
AT264710B (en) 1968-09-10
DE1467833A1 (en) 1968-11-28
DE1467833B2 (en) 1973-10-04
GB1091045A (en) 1967-11-15
DK129243C (en) 1975-02-03
DK129243B (en) 1974-09-16
DE1467833C3 (en) 1974-05-02

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