GB1089616A - Improvements in or relating to furan pyrazolo-pyrimidine compounds - Google Patents
Improvements in or relating to furan pyrazolo-pyrimidine compoundsInfo
- Publication number
- GB1089616A GB1089616A GB1572767A GB1572767A GB1089616A GB 1089616 A GB1089616 A GB 1089616A GB 1572767 A GB1572767 A GB 1572767A GB 1572767 A GB1572767 A GB 1572767A GB 1089616 A GB1089616 A GB 1089616A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- amino
- cyano
- reacting
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of Formula I <FORM:1089616/C2/1> wherein R represents a hydroxy group or an amino group of formula -NXY, where X and Y are hydrogen or hydroxyethyl, and R1 represents an alkyl or methoxyethyl group, are prepared (1) when R is an amino group, by reacting 2-furonitrile with a 5-amino-4-cyano-1 1 - substituted-pyrazole in an inert solvent in the presence of an alkaline condensing agent, or by reacting a 4 - halo - furan - pyrazolo - pyrimidine compound with an amine in the presence of a solvent, and (2) when R is a hydroxy group, by reacting 2-furoyl chloride with a 5-amino-4-cyano - 1 - substituted - pyrazole in a suitable solvent and treating the resulting N -(4-cyano-1- substituted - 5 - pyrazolyl) - 2 - furamide with an oxidizing agent in the presence of a base. The 5 - amino - 4 - cyano - 1 - substituted-pyrazoles may be prepared by reacting ethoxy-methylene-malononitrile with the appropriately substituted hydrazine. 2-Methoxyethylhydrazine is made by treating hydrazine hydrate with 2-methoxy-ethyl chloride.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31850263A | 1963-10-24 | 1963-10-24 | |
| US390207A US3335141A (en) | 1964-08-17 | 1964-08-17 | 4-substituted-1-alkyl-6-(5-nitro-2-furyl)-1h-pyrazolo[3, 4-d]pyrimidines |
| GB43207/64A GB1089615A (en) | 1963-10-24 | 1964-10-22 | Improvements in or relating to nitrofuran pyrazolo-pyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1089616A true GB1089616A (en) | 1967-11-01 |
Family
ID=27259781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1572767A Expired GB1089616A (en) | 1963-10-24 | 1964-10-22 | Improvements in or relating to furan pyrazolo-pyrimidine compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1089616A (en) |
-
1964
- 1964-10-22 GB GB1572767A patent/GB1089616A/en not_active Expired
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