GB1086689A - Pharmaceutically active extracts of bone marrow - Google Patents

Pharmaceutically active extracts of bone marrow

Info

Publication number
GB1086689A
GB1086689A GB48803/64A GB4880364A GB1086689A GB 1086689 A GB1086689 A GB 1086689A GB 48803/64 A GB48803/64 A GB 48803/64A GB 4880364 A GB4880364 A GB 4880364A GB 1086689 A GB1086689 A GB 1086689A
Authority
GB
United Kingdom
Prior art keywords
bone marrow
water
leucine
iso
glycerol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48803/64A
Inventor
Harry Foulds
Alfred Charles King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALKLIAM CHEMICALS Ltd
Original Assignee
ALKLIAM CHEMICALS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALKLIAM CHEMICALS Ltd filed Critical ALKLIAM CHEMICALS Ltd
Priority to GB48803/64A priority Critical patent/GB1086689A/en
Priority to DE19651467765 priority patent/DE1467765A1/en
Priority to FR40415A priority patent/FR4891M/fr
Publication of GB1086689A publication Critical patent/GB1086689A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Solutions of therapeutically active water-soluble substances are prepared by extraction of bone marrow, obtained from cattle suffering from bovine cysticercosis, with water or hydroxylic organic solvents. Such solvents may be ethanol, iso-propanol, propylene glycol or glycerol, and the bone marrow may be extracted by grinding it with the solvent in the presence of an inert abrasive material such as sand. Prior to extraction, the bone marrow is preferably defatted with a fat solvent and treated with a water-miscible ketone, e.g. acetone, and the final extract of the process is filtered, sterilised by filtration and sealed into vials. The active substances may be employed in this form, or preferably after dilution with saline and addition of glycerol, cresol and buffering agents, as compositions for injection, and are said to have anti-tumour activity. The substance comprises a mixture of amino acids, including one or more of leucine, iso-leucine, methionine, cystine, threonine, lysine, valine, and L-phenyl-alanine; vitamins, particularly of the B complex; serum proteins such as albumins, globulins and properdin; indole derivatives, e.g. tryptophan; enzymes, particularly proteinases; amino-aromatic compounds and purine bases; a lipopolysaccharide and iron and molybdenum derivatives. The substance exhibits anti-folic acid activity.
GB48803/64A 1964-12-01 1964-12-01 Pharmaceutically active extracts of bone marrow Expired GB1086689A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB48803/64A GB1086689A (en) 1964-12-01 1964-12-01 Pharmaceutically active extracts of bone marrow
DE19651467765 DE1467765A1 (en) 1964-12-01 1965-12-01 Process for the production of therapeutic masses
FR40415A FR4891M (en) 1964-12-01 1965-12-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB48803/64A GB1086689A (en) 1964-12-01 1964-12-01 Pharmaceutically active extracts of bone marrow

Publications (1)

Publication Number Publication Date
GB1086689A true GB1086689A (en) 1967-10-11

Family

ID=10449950

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48803/64A Expired GB1086689A (en) 1964-12-01 1964-12-01 Pharmaceutically active extracts of bone marrow

Country Status (3)

Country Link
DE (1) DE1467765A1 (en)
FR (1) FR4891M (en)
GB (1) GB1086689A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001367A1 (en) * 1979-11-22 1981-05-28 Cell Eng Ag A water soluble fraction capable of controlling the immune reactions of a host against allogeneic cells or tissue,the pharmaceutical compositions containing said fraction and a process for preparing the latter
WO1988007379A1 (en) * 1987-03-25 1988-10-06 Maier Karl Heinz Microbiological process for obtaining tumour-reducing substances and tumour antibodies in a test glass

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001367A1 (en) * 1979-11-22 1981-05-28 Cell Eng Ag A water soluble fraction capable of controlling the immune reactions of a host against allogeneic cells or tissue,the pharmaceutical compositions containing said fraction and a process for preparing the latter
WO1988007379A1 (en) * 1987-03-25 1988-10-06 Maier Karl Heinz Microbiological process for obtaining tumour-reducing substances and tumour antibodies in a test glass

Also Published As

Publication number Publication date
DE1467765A1 (en) 1968-12-12
FR4891M (en) 1967-03-06

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