GB1084878A - A method of preparing new biologically active, low water-soluble compounds of bacitracin - Google Patents
A method of preparing new biologically active, low water-soluble compounds of bacitracinInfo
- Publication number
- GB1084878A GB1084878A GB42206/65A GB4220665A GB1084878A GB 1084878 A GB1084878 A GB 1084878A GB 42206/65 A GB42206/65 A GB 42206/65A GB 4220665 A GB4220665 A GB 4220665A GB 1084878 A GB1084878 A GB 1084878A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bacitracin
- biologically active
- metal
- low water
- soluble compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010001478 Bacitracin Proteins 0.000 title abstract 4
- 229960003071 bacitracin Drugs 0.000 title abstract 4
- 229930184125 bacitracin Natural products 0.000 title abstract 4
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- 229910052751 metal Inorganic materials 0.000 abstract 4
- 239000002184 metal Substances 0.000 abstract 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001299 aldehydes Chemical class 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 abstract 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ZETIVVHRRQLWFW-UHFFFAOYSA-N 3-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC(C=O)=C1 ZETIVVHRRQLWFW-UHFFFAOYSA-N 0.000 abstract 1
- SXINBFXPADXIEY-UHFFFAOYSA-N 5-Nitrofurfural Chemical compound [O-][N+](=O)C1=CC=C(C=O)O1 SXINBFXPADXIEY-UHFFFAOYSA-N 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- -1 aliphatic aldehydes Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910017052 cobalt Inorganic materials 0.000 abstract 1
- 239000010941 cobalt Substances 0.000 abstract 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000011135 tin Substances 0.000 abstract 1
- 229910052718 tin Inorganic materials 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- C07K7/58—Bacitracins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Baking, Grill, Roasting (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS553064 | 1964-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1084878A true GB1084878A (en) | 1967-09-27 |
Family
ID=5400361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42206/65A Expired GB1084878A (en) | 1964-10-06 | 1965-10-05 | A method of preparing new biologically active, low water-soluble compounds of bacitracin |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3481916A (https=) |
| AT (1) | AT263214B (https=) |
| BE (1) | BE670561A (https=) |
| CH (1) | CH465770A (https=) |
| DE (1) | DE1518328C3 (https=) |
| DK (1) | DK111686B (https=) |
| FI (1) | FI44454B (https=) |
| GB (1) | GB1084878A (https=) |
| NL (1) | NL147134B (https=) |
| NO (1) | NO118708B (https=) |
| SE (1) | SE326524B (https=) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2834711A (en) * | 1956-05-17 | 1958-05-13 | Commercial Solvents Corp | Production of bacitracin |
| US3228836A (en) * | 1962-10-09 | 1966-01-11 | Warner Lambert Pharmaceutical | Aldehyde complexes of colistin and polymyxin antibiotics |
| US3205137A (en) * | 1963-03-19 | 1965-09-07 | Warner Lambert Pharmaceutical | Bacitracin derivatives |
| US3384631A (en) * | 1964-06-26 | 1968-05-21 | Spofa Vereinigte Pharma Werke | Isolation of bacitracin from dilute solutions thereof by precipitation as a complex with a divalent metal and an organic sulfate or sulfonate |
-
1965
- 1965-09-29 CH CH1343665A patent/CH465770A/de unknown
- 1965-10-01 DK DK505465AA patent/DK111686B/da unknown
- 1965-10-01 NO NO159923A patent/NO118708B/no unknown
- 1965-10-04 DE DE1518328A patent/DE1518328C3/de not_active Expired
- 1965-10-04 US US492895A patent/US3481916A/en not_active Expired - Lifetime
- 1965-10-04 NL NL656512824A patent/NL147134B/xx unknown
- 1965-10-05 FI FI2367/65A patent/FI44454B/fi active
- 1965-10-05 AT AT900265A patent/AT263214B/de active
- 1965-10-05 GB GB42206/65A patent/GB1084878A/en not_active Expired
- 1965-10-06 SE SE12965/65A patent/SE326524B/xx unknown
- 1965-10-06 BE BE670561D patent/BE670561A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1518328B2 (de) | 1973-11-15 |
| SE326524B (https=) | 1970-07-27 |
| NL147134B (nl) | 1975-09-15 |
| FI44454B (https=) | 1971-08-02 |
| US3481916A (en) | 1969-12-02 |
| NL6512824A (https=) | 1966-04-07 |
| BE670561A (https=) | 1966-01-31 |
| AT263214B (de) | 1968-07-10 |
| DE1518328A1 (de) | 1969-07-24 |
| CH465770A (de) | 1968-11-30 |
| NO118708B (https=) | 1970-02-02 |
| DE1518328C3 (de) | 1974-06-27 |
| DK111686B (da) | 1968-09-30 |
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