GB1074084A - Dibenzocycloheptene compounds - Google Patents

Dibenzocycloheptene compounds

Info

Publication number
GB1074084A
GB1074084A GB35403/66A GB3540366A GB1074084A GB 1074084 A GB1074084 A GB 1074084A GB 35403/66 A GB35403/66 A GB 35403/66A GB 3540366 A GB3540366 A GB 3540366A GB 1074084 A GB1074084 A GB 1074084A
Authority
GB
United Kingdom
Prior art keywords
compounds
formula
alkyl
radical
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35403/66A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1074084A publication Critical patent/GB1074084A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises compounds of the Formula I, wherein R0 represents a C1- 6 alkyl radical, each of R11 and R111 represents a hydrogen atom or an alkyl, aryl or aralkyl radical and each of X and X1 represents a hydrogen or halogen atom or a C1- 6 alkyl, C2- 6 alkenyl, trifluoromethyl, hydroxyl, C1- 4 alkoxy, mercapto, C1- 4 alkylmercapto, C1- 4 alkylsulphonyl, sulphamoyl, C1- 4 alkylsulphamoyl, C2- 8 dialkylsulphamoyl radical; their preparation by reacting a compound of the Formula II with a cyanogen halide; and the conversion of compounds of the Formula I into compounds of the Formula III by alkaline hydrolysis. <FORM:1074084/C2/1> <FORM:1074084/C2/2> <FORM:1074084/C2/3>
GB35403/66A 1963-07-22 1964-07-09 Dibenzocycloheptene compounds Expired GB1074084A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US296463A US3390179A (en) 1963-07-22 1963-07-22 Novel 10, 11-dihydro-10, 11-dihydroxy-(3-substituted aminopropylidene)-5h-dibenzo [a, d] cycloheptenes
US4847870A 1970-06-22 1970-06-22

Publications (1)

Publication Number Publication Date
GB1074084A true GB1074084A (en) 1967-06-28

Family

ID=26726156

Family Applications (4)

Application Number Title Priority Date Filing Date
GB35402/66A Expired GB1074083A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds
GB35403/66A Expired GB1074084A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds
GB35404/66A Expired GB1074085A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds
GB28412/64A Expired GB1074082A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB35402/66A Expired GB1074083A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB35404/66A Expired GB1074085A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds
GB28412/64A Expired GB1074082A (en) 1963-07-22 1964-07-09 Dibenzocycloheptene compounds

Country Status (11)

Country Link
US (2) US3390179A (en)
BE (1) BE650800A (en)
BR (1) BR6460953D0 (en)
CH (1) CH494731A (en)
DE (1) DE1468339A1 (en)
DK (3) DK127723B (en)
FR (2) FR1572128A (en)
GB (4) GB1074083A (en)
IL (2) IL21665A (en)
NL (1) NL6408390A (en)
SE (3) SE332820B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905981A (en) * 1973-10-12 1975-09-16 Research Corp N-dealkylation of tertiary amines
US4089864A (en) * 1974-03-25 1978-05-16 Merck & Co., Inc. 4-(10,11-Dihydro-cis and trans-10,11-dihydroxy-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidines
US3894032A (en) * 1974-04-10 1975-07-08 Merck & Co Inc 10,11-Furo derivatives of cyproheptadine
US4044143A (en) * 1975-01-30 1977-08-23 Merck & Co., Inc. 10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine
DE4232173A1 (en) * 1992-09-25 1994-03-31 Bayer Ag 5-oxo-dibenzo (a, d) cyclohepta-1,4-diene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3234279A (en) * 1962-09-14 1966-02-08 Merck & Co Inc 5-(gamma-amino-propyl- and propylidene-) 5h-dibenzo[a, d]-10-hydroxy-10, 11-dihydrocycloheptenes and amine borane salts thereof

Also Published As

Publication number Publication date
CH494731A (en) 1970-08-15
FR3905M (en) 1966-02-07
DK121856B (en) 1971-12-13
SE320963B (en) 1970-02-23
GB1074083A (en) 1967-06-28
IL21665A (en) 1969-01-29
US3660389A (en) 1972-05-02
US3390179A (en) 1968-06-25
BE650800A (en) 1965-01-20
GB1074082A (en) 1967-06-28
GB1074085A (en) 1967-06-28
DK127723B (en) 1973-12-24
SE332819B (en) 1971-02-22
NL6408390A (en) 1965-01-25
DK121757B (en) 1971-11-29
SE332820B (en) 1971-02-22
IL29677A (en) 1969-01-29
BR6460953D0 (en) 1973-08-02
DE1468339A1 (en) 1968-12-19
FR1572128A (en) 1969-06-27

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