GB1072413A - New dihydrothieno[3,2-d]pyrimidines - Google Patents
New dihydrothieno[3,2-d]pyrimidinesInfo
- Publication number
- GB1072413A GB1072413A GB2509364A GB2509364A GB1072413A GB 1072413 A GB1072413 A GB 1072413A GB 2509364 A GB2509364 A GB 2509364A GB 2509364 A GB2509364 A GB 2509364A GB 1072413 A GB1072413 A GB 1072413A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- alkyl
- compound
- free
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 19
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 8
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 4
- 231100000252 nontoxic Toxicity 0.000 abstract 4
- 230000003000 nontoxic effect Effects 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 230000002152 alkylating effect Effects 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000012435 aralkylating agent Substances 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- -1 with cardiovascular Substances 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- YLXPWYRUCAELPW-UHFFFAOYSA-N 2-hydroxy-2,3-dihydro-1h-thieno[3,2-d]pyrimidin-4-one Chemical compound O=C1NC(O)NC2=C1SC=C2 YLXPWYRUCAELPW-UHFFFAOYSA-N 0.000 abstract 1
- BFQWFNHNECLMAJ-UHFFFAOYSA-N 3-iminothiolane-2-carboxylic acid Chemical compound N=C1C(SCC1)C(=O)O BFQWFNHNECLMAJ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000006196 drop Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-M hydrosulfide Chemical compound [SH-] RWSOTUBLDIXVET-UHFFFAOYSA-M 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US288491A US3272811A (en) | 1962-07-04 | 1963-06-17 | Dihydrothieno-[3, 4-d]-pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1072413A true GB1072413A (en) | 1967-06-14 |
Family
ID=23107339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2509364A Expired GB1072413A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno[3,2-d]pyrimidines |
| GB2509464A Expired GB1072414A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno(3,2-d)pyrimidines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2509464A Expired GB1072414A (en) | 1963-06-17 | 1964-06-17 | New dihydrothieno(3,2-d)pyrimidines |
Country Status (7)
| Country | Link |
|---|---|
| BE (2) | BE649348A (enrdf_load_stackoverflow) |
| CH (2) | CH442328A (enrdf_load_stackoverflow) |
| ES (1) | ES301103A1 (enrdf_load_stackoverflow) |
| FR (4) | FR3824M (enrdf_load_stackoverflow) |
| GB (2) | GB1072413A (enrdf_load_stackoverflow) |
| NL (4) | NL6406834A (enrdf_load_stackoverflow) |
| SE (2) | SE300214B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0276057A3 (en) * | 1987-01-21 | 1989-09-06 | Merck & Co. Inc. | Piperazinylpyrimidines as b-adrenergic receptor blocking agents |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| EP2060575A1 (de) | 2006-04-19 | 2009-05-20 | Boehringer Ingelheim International GmbH | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| US8486948B2 (en) | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
| MX2010003346A (es) | 2007-10-19 | 2010-04-09 | Boehringer Ingelheim Int | Piperazino-dihidrotienopirimidinas sustituidas en heterociclo. |
| EP2215092B1 (de) | 2007-10-19 | 2012-01-25 | Boehringer Ingelheim International GmbH | Substituierte piperidino-dihydrothienopyrimidine |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
-
0
- NL NL122810A patent/NL122810C/xx active
- NL NL124131A patent/NL124131C/xx active
-
1964
- 1964-05-28 CH CH695364A patent/CH442328A/de unknown
- 1964-05-28 CH CH695264A patent/CH446358A/de unknown
- 1964-06-05 SE SE686864A patent/SE300214B/xx unknown
- 1964-06-05 SE SE686764A patent/SE300213B/xx unknown
- 1964-06-15 FR FR978344A patent/FR3824M/fr not_active Expired
- 1964-06-15 FR FR978342A patent/FR1555459A/fr not_active Expired
- 1964-06-15 FR FR978343A patent/FR1555460A/fr not_active Expired
- 1964-06-16 BE BE649348A patent/BE649348A/xx unknown
- 1964-06-16 NL NL6406834A patent/NL6406834A/xx unknown
- 1964-06-16 ES ES0301103A patent/ES301103A1/es not_active Expired
- 1964-06-16 NL NL6406835A patent/NL6406835A/xx unknown
- 1964-06-16 BE BE649347A patent/BE649347A/xx unknown
- 1964-06-17 GB GB2509364A patent/GB1072413A/en not_active Expired
- 1964-06-17 GB GB2509464A patent/GB1072414A/en not_active Expired
- 1964-09-04 FR FR987185A patent/FR3648M/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0276057A3 (en) * | 1987-01-21 | 1989-09-06 | Merck & Co. Inc. | Piperazinylpyrimidines as b-adrenergic receptor blocking agents |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6406834A (enrdf_load_stackoverflow) | 1964-12-18 |
| CH446358A (de) | 1967-11-15 |
| GB1072414A (en) | 1967-06-14 |
| NL6406835A (enrdf_load_stackoverflow) | 1964-12-18 |
| BE649348A (enrdf_load_stackoverflow) | 1964-12-16 |
| NL122810C (enrdf_load_stackoverflow) | |
| ES301103A1 (es) | 1965-01-16 |
| FR3648M (fr) | 1965-10-25 |
| BE649347A (enrdf_load_stackoverflow) | 1964-12-16 |
| SE300214B (enrdf_load_stackoverflow) | 1968-04-22 |
| CH442328A (de) | 1967-08-31 |
| FR3824M (fr) | 1966-01-10 |
| SE300213B (enrdf_load_stackoverflow) | 1968-04-22 |
| NL124131C (enrdf_load_stackoverflow) | |
| FR1555460A (enrdf_load_stackoverflow) | 1969-01-31 |
| FR1555459A (enrdf_load_stackoverflow) | 1969-01-31 |
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