GB1066917A - Novel isoquinoline derivatives and a process for the manufacture thereof - Google Patents
Novel isoquinoline derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1066917A GB1066917A GB1400165A GB1400165A GB1066917A GB 1066917 A GB1066917 A GB 1066917A GB 1400165 A GB1400165 A GB 1400165A GB 1400165 A GB1400165 A GB 1400165A GB 1066917 A GB1066917 A GB 1066917A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- acid
- isoquinolones
- specifications
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel isoquinolones of the formula <FORM:1066917/C2/1> (wherein R1 is phenyl or C1- 7 alkyl; R2 i benzyl, C1- 7 alkyl or a C1- 7 alkyl-substituted benzyl group; R3 is C1- 7 alkyl; and R4, R5 and R6 are C1- 7 alkyl or C1- 7 alkoxy; and the broken lines denote that the groups attached thereby are optional; and wherein at least one of R1 and R2 is present and is other than C1- 7 alkyl) and acid-addition salts thereof, are prepared by treating an acid or ester of the formula <FORM:1066917/C2/2> (wherein R7 is C1- 7 alkyl) with a dehydrating agent. This acid or ester is prepared in turn by the methods disclosed in Specifications 1,066,918 and 1,066,919 which, although in these Specifications are restricted to the preparation of compounds represented by general formulae of narrower scope than those necessary in the present process, are, nevertheless, generally applicable to the preparation of the present starting materials. The isoquinolones of the invention, which are stated to be short-acting vaso depressors, may be made up into pharmaceutical compositions for enteral or parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35731864A | 1964-04-03 | 1964-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1066917A true GB1066917A (en) | 1967-04-26 |
Family
ID=23405107
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2846266A Expired GB1066919A (en) | 1964-04-03 | 1965-04-02 | Novel benzyl amine derivatives |
| GB2846166A Expired GB1066918A (en) | 1964-04-03 | 1965-04-02 | Novel glycine derivatives |
| GB1400165A Expired GB1066917A (en) | 1964-04-03 | 1965-04-02 | Novel isoquinoline derivatives and a process for the manufacture thereof |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2846266A Expired GB1066919A (en) | 1964-04-03 | 1965-04-02 | Novel benzyl amine derivatives |
| GB2846166A Expired GB1066918A (en) | 1964-04-03 | 1965-04-02 | Novel glycine derivatives |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE661965A (en) |
| GB (3) | GB1066919A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302460A (en) | 1979-03-27 | 1981-11-24 | The Boots Company Limited | 4-Quinolinones having antihypertensive activity |
-
1965
- 1965-04-02 GB GB2846266A patent/GB1066919A/en not_active Expired
- 1965-04-02 BE BE661965D patent/BE661965A/xx unknown
- 1965-04-02 GB GB2846166A patent/GB1066918A/en not_active Expired
- 1965-04-02 GB GB1400165A patent/GB1066917A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302460A (en) | 1979-03-27 | 1981-11-24 | The Boots Company Limited | 4-Quinolinones having antihypertensive activity |
Also Published As
| Publication number | Publication date |
|---|---|
| GB1066918A (en) | 1967-04-26 |
| GB1066919A (en) | 1967-04-26 |
| BE661965A (en) | 1965-10-04 |
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