GB1066459A - Diagnostic aid - Google Patents

Diagnostic aid

Info

Publication number
GB1066459A
GB1066459A GB33498/64A GB3349864A GB1066459A GB 1066459 A GB1066459 A GB 1066459A GB 33498/64 A GB33498/64 A GB 33498/64A GB 3349864 A GB3349864 A GB 3349864A GB 1066459 A GB1066459 A GB 1066459A
Authority
GB
United Kingdom
Prior art keywords
cholesterol
carbon atoms
ethylene oxide
composition
blood plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33498/64A
Inventor
Charles Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Pharmaceutical Co filed Critical Warner Lambert Pharmaceutical Co
Publication of GB1066459A publication Critical patent/GB1066459A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/106664—Blood serum or blood plasma standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A composition comprising a standard amount of cholesterol and cholesterol esters of fatty acids ("total cholesterol"), lyophilised human blood plasma and a solubilizing compound RO(CH2CH2O)nH where R is a straight or branched chain alkyl group having 12-18 carbon atoms, an alkyl phenoxy group having 1-9 carbon atoms in the alkyl group or an acyl group having 12-22 carbon atoms and n=10-20 may be used as a standard in determining total cholesterol in blood. The composition has an optical density of less than 0.450 at 620 mm when reconstituted. The only cholesterol ester specified is the acetate: specified solubilizing compounds and compositions are (a) oleyl alcohol/ethylene oxide condensate (if desired together with a polyoxyethylene-polyoxypropylene condensate), (b) a mixture of nonylphenoxy/ and stearyl/ethylene oxide condensates, and (c) a mixture of nonylphenoxy/and oleyl/ethylene oxide condensates. The composition may be prepared, if desired, immediately before use by adding the total cholesterol components to processed blood plasma together with the solubilizing agent mixed with hot water, or the cholesterol may be first solubilized. The Specification describes a test for cholesterol in blood plasma comprising adding alcoholic KOH; extracting with petroleum ether and determining the optical density after adding Liebermann-Burchard reagent.
GB33498/64A 1963-08-16 1964-08-17 Diagnostic aid Expired GB1066459A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US302702A US3260648A (en) 1963-08-16 1963-08-16 Diagnostic aid

Publications (1)

Publication Number Publication Date
GB1066459A true GB1066459A (en) 1967-04-26

Family

ID=23168865

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33498/64A Expired GB1066459A (en) 1963-08-16 1964-08-17 Diagnostic aid

Country Status (4)

Country Link
US (1) US3260648A (en)
DE (1) DE1523133C3 (en)
ES (1) ES303140A1 (en)
GB (1) GB1066459A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764556A (en) * 1971-02-02 1973-10-09 Us Health Education & Welfare Alcoholic precipitation and 1000x centrifugation preparation of hypercholesterolemic and hypertriglyceridemic sera as lipid determination control
FR2495184A1 (en) * 1980-10-01 1982-06-04 Technicon Instr METHOD AND REAGENT FOR CLARIFYING A DISORDERED BIOLOGICAL LIQUID
EP0606616A1 (en) * 1993-01-09 1994-07-20 BEHRINGWERKE Aktiengesellschaft Hydrophobic absorbents and their use for lipoproteins adsorption

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3615232A (en) * 1970-02-05 1971-10-26 Research Corp Method and reagent for determining total cholesterol in blood serum
US3853465A (en) * 1972-06-09 1974-12-10 Technicon Instr Turbidity reduction in serum and plasma samples using polyoxyethylated lauric acid compounds
US3955925A (en) * 1973-11-12 1976-05-11 Proksch Gary J Preparation of optically clear serum
US4011045A (en) * 1975-02-14 1977-03-08 Bonderman Dean P Turbidity reduction in triglyceride standards
US4045176A (en) * 1975-06-13 1977-08-30 Proksch Gary J Preparation of optically clear serum
US4127502A (en) * 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4189400A (en) * 1977-08-17 1980-02-19 Bonderman Dean P Compound useful in cholesterol assay procedures
US4216117A (en) * 1978-05-15 1980-08-05 Bonderman Dean P Lipoprotein diluent or solution and method useful in the preparation of assay reference materials
DE2829531A1 (en) * 1978-07-05 1980-01-24 Heuck Claus Christian Dr Rer N METHOD FOR QUANTITATIVE DETERMINATION OF A SERUM PROTEIN IN BLUE SERUM AND PLASMA SAMPLES
DE2839433A1 (en) * 1978-09-11 1980-03-20 Merck Patent Gmbh STANDARD AQUEOUS LIPID SOLUTION AND METHOD FOR THEIR PRODUCTION
US4239649A (en) * 1979-01-25 1980-12-16 Sherwood Medical Industries Inc. Cholesterol standard
DE3107060A1 (en) * 1981-02-25 1982-09-09 Boehringer Mannheim Gmbh, 6800 Mannheim CONTROL OR CALIBRATION SERUM AND METHOD FOR THE PRODUCTION THEREOF
DE3329952A1 (en) * 1983-08-19 1985-02-28 Behringwerke Ag, 3550 Marburg METHOD FOR REDUCING TURBIDITY IN CONTROL SERIES
US5310679A (en) * 1985-05-13 1994-05-10 Artiss Joseph D Composition for reducing turbidity in samples of biological fluids
US4626511A (en) * 1985-05-13 1986-12-02 Wayne State University Composition for reducing turbidity in samples of biological fluids
US5296377A (en) * 1992-12-15 1994-03-22 Boehringer Mannheim Corporation Control reagent containing a hydroxylamine or an antioxidant
US5614414A (en) * 1995-03-30 1997-03-25 Streck Laboratories, Inc. Liquid lipoprotein control
US5770451A (en) * 1995-03-30 1998-06-23 Streck Laboratories, Inc. Liquid lipoprotein control
JP7110360B2 (en) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー Freeze-drying method
JP7495426B2 (en) 2019-03-14 2024-06-04 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー Filling tool for freeze-drying containers, system and method of use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764556A (en) * 1971-02-02 1973-10-09 Us Health Education & Welfare Alcoholic precipitation and 1000x centrifugation preparation of hypercholesterolemic and hypertriglyceridemic sera as lipid determination control
FR2495184A1 (en) * 1980-10-01 1982-06-04 Technicon Instr METHOD AND REAGENT FOR CLARIFYING A DISORDERED BIOLOGICAL LIQUID
EP0606616A1 (en) * 1993-01-09 1994-07-20 BEHRINGWERKE Aktiengesellschaft Hydrophobic absorbents and their use for lipoproteins adsorption
US5482914A (en) * 1993-01-09 1996-01-09 Behringwerke Aktiengesellschaft Hydrophobic adsorbents and their use for the adsorption of lipoproteins

Also Published As

Publication number Publication date
DE1523133A1 (en) 1969-09-11
ES303140A1 (en) 1965-02-01
US3260648A (en) 1966-07-12
DE1523133C3 (en) 1974-01-03
DE1523133B2 (en) 1970-11-05

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