GB1065715A - Tetracycline derivatives - Google Patents

Info

Publication number

GB1065715A

GB1065715A GB2663764A GB2663764A GB1065715A GB 1065715 A GB1065715 A GB 1065715A GB 2663764 A GB2663764 A GB 2663764A GB 2663764 A GB2663764 A GB 2663764A GB 1065715 A GB1065715 A GB 1065715A

Authority

GB

United Kingdom

Prior art keywords

alkyl

compound

formula

bond

benzyl

Prior art date

1964-04-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• 239000004098 Tetracycline Substances 0.000 title abstract 2
• 229960002180 tetracycline Drugs 0.000 title abstract 2
• 229930101283 tetracycline Natural products 0.000 title abstract 2
• 235000019364 tetracycline Nutrition 0.000 title abstract 2
• 150000003522 tetracyclines Chemical class 0.000 title 1
• 125000000217 alkyl group Chemical group 0.000 abstract 6
• 150000001875 compounds Chemical class 0.000 abstract 6
• -1 tetracycline compounds Chemical class 0.000 abstract 5
• 239000002253 acid Substances 0.000 abstract 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
• 150000003839 salts Chemical class 0.000 abstract 2
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
• GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
• 150000001299 aldehydes Chemical class 0.000 abstract 1
• 230000002152 alkylating effect Effects 0.000 abstract 1
• 229910021529 ammonia Inorganic materials 0.000 abstract 1
• 239000002585 base Substances 0.000 abstract 1
• 239000003054 catalyst Substances 0.000 abstract 1
• 239000007795 chemical reaction product Substances 0.000 abstract 1
• 239000003638 chemical reducing agent Substances 0.000 abstract 1
• 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
• 239000012458 free base Substances 0.000 abstract 1
• 229910052736 halogen Inorganic materials 0.000 abstract 1
• 150000002367 halogens Chemical class 0.000 abstract 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
• 150000002576 ketones Chemical class 0.000 abstract 1
• 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
• 239000002516 radical scavenger Substances 0.000 abstract 1
• 239000000376 reactant Substances 0.000 abstract 1
• 238000006268 reductive amination reaction Methods 0.000 abstract 1
• 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1