GB1058835A - Thiosemicarbazones of benzaldehyde compounds - Google Patents
Thiosemicarbazones of benzaldehyde compoundsInfo
- Publication number
- GB1058835A GB1058835A GB17135/64A GB1713564A GB1058835A GB 1058835 A GB1058835 A GB 1058835A GB 17135/64 A GB17135/64 A GB 17135/64A GB 1713564 A GB1713564 A GB 1713564A GB 1058835 A GB1058835 A GB 1058835A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- thiosemicarbazide
- thiosemicarbazones
- combination
- thiosemicarbazone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003935 benzaldehydes Chemical class 0.000 title abstract 2
- 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 title 1
- 150000003584 thiosemicarbazones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 abstract 2
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 abstract 2
- AKGUXECGGCUDCV-UXBLZVDNSA-N [(e)-benzylideneamino]urea Chemical class NC(=O)N\N=C\C1=CC=CC=C1 AKGUXECGGCUDCV-UXBLZVDNSA-N 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzenecarboxaldehyde Natural products O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of formula <FORM:1058835/C2/1> wherein R is a hydrogen atom or an alkyl or alkenyl group and R1, R2 and R3 are alkyl groups, and their preparation by (a) reacting a substituted benzaldehyde with a thiosemicarbazide, a precursor therefor, a combination of compounds capable of forming a thiosemicarbazide, or an aldehyde or ketone thiosemicarbazone, or (b) conversion of a substituted benzaldehyde semicarbazone into a thiosemicarbazone. The compounds of the invention have anti-viral and anti-bacterial activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE451363 | 1963-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1058835A true GB1058835A (en) | 1967-02-15 |
Family
ID=20264358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17135/64A Expired GB1058835A (en) | 1963-04-24 | 1964-04-24 | Thiosemicarbazones of benzaldehyde compounds |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT258933B (en) |
| BE (1) | BE646877A (en) |
| CH (1) | CH468363A (en) |
| DE (1) | DE1443397A1 (en) |
| ES (1) | ES299054A1 (en) |
| FR (1) | FR3686M (en) |
| GB (1) | GB1058835A (en) |
| NL (1) | NL6404565A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719221A (en) * | 1983-07-28 | 1988-01-12 | Burroughs Wellcome Co. | 2-acetylpyrimidine-5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone and salts thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58152815A (en) * | 1982-03-05 | 1983-09-10 | Tamio Nishimura | Virucide |
-
1964
- 1964-04-10 AT AT315764A patent/AT258933B/en active
- 1964-04-22 BE BE646877D patent/BE646877A/xx unknown
- 1964-04-23 FR FR972051A patent/FR3686M/en not_active Expired
- 1964-04-23 DE DE19641443397 patent/DE1443397A1/en active Pending
- 1964-04-23 ES ES299054A patent/ES299054A1/en not_active Expired
- 1964-04-24 NL NL6404565A patent/NL6404565A/xx unknown
- 1964-04-24 GB GB17135/64A patent/GB1058835A/en not_active Expired
- 1964-04-24 CH CH535164A patent/CH468363A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719221A (en) * | 1983-07-28 | 1988-01-12 | Burroughs Wellcome Co. | 2-acetylpyrimidine-5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone and salts thereof |
| US4758572A (en) * | 1983-07-28 | 1988-07-19 | Burroughs Wellcome Co. | Antiviral combinations |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3686M (en) | 1965-11-15 |
| CH468363A (en) | 1969-02-15 |
| ES299054A1 (en) | 1964-10-16 |
| BE646877A (en) | 1964-08-17 |
| NL6404565A (en) | 1964-10-26 |
| AT258933B (en) | 1967-12-27 |
| DE1443397A1 (en) | 1969-01-16 |
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