GB1049026A - Process for the manufacture of 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones and new 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones - Google Patents

Process for the manufacture of 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones and new 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones

Info

Publication number
GB1049026A
GB1049026A GB2126764A GB2126764A GB1049026A GB 1049026 A GB1049026 A GB 1049026A GB 2126764 A GB2126764 A GB 2126764A GB 2126764 A GB2126764 A GB 2126764A GB 1049026 A GB1049026 A GB 1049026A
Authority
GB
United Kingdom
Prior art keywords
hydroxyprogesterones
methylene
manufacture
new
hydrolysed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2126764A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB1049026A publication Critical patent/GB1049026A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

The invention comprises compounds having the formula <FORM:1049026/C2/1> in which R is hydrogen, halogen or alkyl and a process for the manufacture thereof in which the corresponding 17-ester is hydrolysed, preferably with an alkaline hydrolysing agent, and the resulting free 17a -hydroxyl compound is isolated.
GB2126764A 1963-05-31 1964-05-22 Process for the manufacture of 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones and new 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones Expired GB1049026A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH33365A DE1189991B (en) 1963-05-31 1963-05-31 Process for the preparation of 1,2alpha-methylene-delta-17alpha-hydroxy-progesterones

Publications (1)

Publication Number Publication Date
GB1049026A true GB1049026A (en) 1966-11-23

Family

ID=7432762

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2126764A Expired GB1049026A (en) 1963-05-31 1964-05-22 Process for the manufacture of 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones and new 1,2ª‡-methylene-í¸-17ª‡-hydroxyprogesterones

Country Status (4)

Country Link
CH (1) CH433285A (en)
DE (1) DE1189991B (en)
GB (1) GB1049026A (en)
NL (1) NL142671B (en)

Also Published As

Publication number Publication date
NL6404660A (en) 1964-12-01
DE1189991B (en) 1965-04-01
NL142671B (en) 1974-07-15
CH433285A (en) 1967-04-15

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