GB1048868A - New pyridobenzothiadiazepine derivatives and process for producing same - Google Patents
New pyridobenzothiadiazepine derivatives and process for producing sameInfo
- Publication number
- GB1048868A GB1048868A GB3287/65A GB328765A GB1048868A GB 1048868 A GB1048868 A GB 1048868A GB 3287/65 A GB3287/65 A GB 3287/65A GB 328765 A GB328765 A GB 328765A GB 1048868 A GB1048868 A GB 1048868A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- prepared
- compound
- chlorine
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MNIASYGCMZJLPA-UHFFFAOYSA-N pyrido[2,3-i][1,2,3]benzothiadiazepine Chemical class S1N=NC=CC2=C1C1=C(C=C2)N=CC=C1 MNIASYGCMZJLPA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- -1 methylene dioxy group Chemical group 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 abstract 2
- HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical class OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- LYESTQKHIPXVIK-UHFFFAOYSA-N 4-chloro-2-nitrobenzenesulfonyl chloride Chemical compound [O-][N+](=O)C1=CC(Cl)=CC=C1S(Cl)(=O)=O LYESTQKHIPXVIK-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34054264A | 1964-01-27 | 1964-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1048868A true GB1048868A (en) | 1966-11-23 |
Family
ID=23333836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3288/65A Expired GB1048869A (en) | 1964-01-27 | 1965-01-26 | New benzothiadiazepine derivatives |
| GB3287/65A Expired GB1048868A (en) | 1964-01-27 | 1965-01-26 | New pyridobenzothiadiazepine derivatives and process for producing same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3288/65A Expired GB1048869A (en) | 1964-01-27 | 1965-01-26 | New benzothiadiazepine derivatives |
Country Status (7)
| Country | Link |
|---|---|
| AT (2) | AT251590B (enExample) |
| BE (2) | BE658844A (enExample) |
| CH (2) | CH441345A (enExample) |
| ES (2) | ES308570A1 (enExample) |
| FR (2) | FR4415M (enExample) |
| GB (2) | GB1048869A (enExample) |
| NL (3) | NL6500953A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3506646A (en) * | 1966-06-27 | 1970-04-14 | American Home Prod | Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides |
-
0
- NL NL123600D patent/NL123600C/xx active
-
1964
- 1964-12-31 CH CH1688064A patent/CH441345A/de unknown
- 1964-12-31 CH CH1688164A patent/CH443321A/de unknown
-
1965
- 1965-01-26 ES ES0308570A patent/ES308570A1/es not_active Expired
- 1965-01-26 BE BE658844D patent/BE658844A/xx unknown
- 1965-01-26 GB GB3288/65A patent/GB1048869A/en not_active Expired
- 1965-01-26 NL NL6500953A patent/NL6500953A/xx unknown
- 1965-01-26 ES ES0308569A patent/ES308569A1/es not_active Expired
- 1965-01-26 AT AT65365A patent/AT251590B/de active
- 1965-01-26 NL NL6500954A patent/NL6500954A/xx unknown
- 1965-01-26 GB GB3287/65A patent/GB1048868A/en not_active Expired
- 1965-01-26 BE BE658845D patent/BE658845A/xx unknown
- 1965-01-26 AT AT65465A patent/AT250972B/de active
- 1965-04-24 FR FR14529A patent/FR4415M/fr not_active Expired
- 1965-04-24 FR FR14530A patent/FR4416M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6500953A (enExample) | 1965-07-28 |
| BE658844A (enExample) | 1965-07-26 |
| FR4416M (enExample) | 1966-09-12 |
| AT251590B (de) | 1967-01-10 |
| ES308569A1 (es) | 1965-07-01 |
| NL6500954A (enExample) | 1965-07-28 |
| CH443321A (de) | 1967-09-15 |
| ES308570A1 (es) | 1965-06-01 |
| BE658845A (enExample) | 1965-07-26 |
| GB1048869A (en) | 1966-11-23 |
| FR4415M (enExample) | 1966-09-12 |
| AT250972B (de) | 1966-12-12 |
| CH441345A (de) | 1967-08-15 |
| NL123600C (enExample) |
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